Hypertension and Alzheimer's disease pathology at autopsy: A systematic review

Abdulrahman, Hanna; Dalen, Jan Willem van; Brok, Melina den; Latimer, Caitlin S.; Larson, Eric B.; Richard, Edo

doi:10.1002/alz.12707

Cited by 22 publications

(11 citation statements)

References 77 publications

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“…Although hypertension and AD are closely related, the mechanism responsible for the association is not clear [ 42 ]. Animal experiments indicate that hypertension activates receptors for advanced glycation end products (RAGE) in the cerebrovascular system via oxidative stress, and mediates the transcytosis of Aβ across brain endothelial cells, resulting in Aβ accumulation, cognitive impairment, and memory degradation [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Association of APP gene polymorphisms and promoter methylation with essential hypertension in Guizhou: a case–control study

Song

Zhao

et al. 2023

Hum Genomics

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Background Single-nucleotide polymorphisms (SNPs) and DNA methylation are crucial regulators of essential hypertension (EH). Amyloid precursor protein (APP) mutations are implicated in hypertension development. Nonetheless, studies on the association of APP gene polymorphism and promoter methylation with hypertension are limited. Therefore, this case–control aims to evaluate the genetic association of APP gene polymorphism and promoter methylation with EH in Guizhou populations. Objective and methods We conducted a case–control study on 343 EH patients and 335 healthy controls (including Miao, Buyi, and Han populations) in the Guizhou province of China to analyze 11 single-nucleotide polymorphisms (rs2040273, rs63750921, rs2211772, rs2830077, rs467021, rs368196, rs466433, rs364048, rs364051, rs438031, rs463946) in the APP gene via MassARRAY SNP. The MassARRAY EpiTYPER was employed to detect the methylation levels of the promoters. Results In the Han population, the rs2211772 genotype distribution was significantly different between disease and control groups (χ2 = 6.343, P = 0.039). The CC genotype reduced the risk of hypertension compared to the TT or TC genotype (OR 0.105, 95%CI 0.012–0.914, P = 0.041). For rs2040273 in the Miao population, AG or GG genotype reduced the hypertension risk compared with the AA genotype (OR 0.533, 95%CI 0.294–0.965, P = 0.038). Haplotype TCC (rs364051–rs438031–rs463946) increased the risk of EH in Guizhou (OR 1.427, 95%CI 1.020–1.996, P = 0.037). Each 1% increase in CpG_19 (− 613 bp) methylation level was associated with a 4.1% increase in hypertension risk (OR 1.041, 95%CI 1.002–1.081, P = 0.039). Each 1% increase in CpG_1 (− 296 bp) methylation level was associated with an 8% decrease in hypertension risk in women (OR 0.920, 95%CI 0.860–0.984, P = 0.015). CpG_19 significantly correlated with systolic blood pressure (r = 0.2, P = 0.03). The methylation levels of CpG_19 in hypertensive patients with rs466433, rs364048, and rs364051 minor alleles were lower than that with wild-type alleles (P < 0.05). Moreover, rs467021 and rs364051 showed strong synergistic interaction with EH (χ2 = 7.633, P = 0.006). CpG_11, CpG_19, and rs364051 showed weak synergistic interaction with EH (χ2 = 19.874, P < 0.001). Conclusion In summary, rs2211772 polymorphism and promoter methylation level of APP gene may be linked to EH in Guizhou populations. Our findings will provide novel insights for genetic research of hypertension and Alzheimer's disease.

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Section: Discussionmentioning

confidence: 99%

Association of APP gene polymorphisms and promoter methylation with essential hypertension in Guizhou: a case–control study

Song

Zhao

et al. 2023

Hum Genomics

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“…Hypertension is closely related to Alzheimer’s disease (AD), but the pathogenic mechanism between them is largely unclear [ 33 ]. NOS3-mediated oxidative stress is associated with amyloid-beta deposition, affecting AD development [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Polymorphism of NOS3 gene and its association with essential hypertension in Guizhou populations of China

Zhao

Diao

et al. 2023

PLoS ONE

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Objective A case-control study was conducted to evaluate the relationship between endothelial nitric oxide synthase (NOS3) gene polymorphism and essential hypertension in the Han, Miao, and Buyi populations in Guizhou China. Methods DNA was collected from the blood samples of 353 essential hypertension patients and 342 healthy controls from Guizhou province of China. Eight polymorphisms of the NOS3 gene were genotyped using the Sequenom MassARRAY platform. For genetic analysis, SPSS 26.0, Haploview, SNPStats, SHEsis, and MDR were utilized. Results All SNPs (rs11771443, rs1808593, rs753482, rs3918186, rs3918188, rs3918227, rs7830, and rs891512) satisfied the Hardy-Weinberg equilibrium test (P > 0.05). The allele and genotype frequencies of rs7830 and rs1808593 in case-control groups demonstrated significant differences (P < 0.05). Compared to the TT genotype of rs1808593, the TG or GG genotype reduced the risk of hypertension in the Miao population (OR = 0.410, 95% CI: 0.218–0.770, P = 0.006). Compared to the GG or GT genotype of rs7830, the TT genotype increased the risk of hypertension in the overall populations (OR = 1.716, 95%CI: 1.139–2.586, P = 0.010). The CATT (rs3918227-rs391818186-rs1808593-rs7830) haplotype was a risk factor for hypertension in the Miao and Han populations (OR = 1.471, 95%CI: 1.010–2.143, P = 0.044 and OR = 1.692, 95%CI: 1.124–2.545, P = 0.011). The CAGG haplotype in the Miao population was a protective factor against hypertension (OR = 0.555, 95%CI: 0.330–0.934, P = 0.025). The rs3918188, rs1808593, and rs7830 in the Miao population showed an interaction effect on hypertension (P < 0.001). The rs11771443, rs3918188, and rs7830 in the Buyi and Han populations showed an interaction effect on hypertension (P = 0.013 and P < 0.001). Conclusion The single nucleotide polymorphisms rs1808593 and rs7830 of NOS3 gene are associated with essential hypertension in Guizhou ethnic populations.

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“…It is reported by the China Patient‐Centered Evaluative Assessment of Cardiac Events (PEACE) Million Persons Project, that nearly half of Chinese adults aged 35–75 years suffer from hypertension and fewer than one in twelve are in control of their blood pressure 1 . Hypertension is known to be related not only to cardiovascular events such as coronary heart disease, arrhythmia and heart failure but also to a positive association with Alzheimer's disease, 2 and a direct relationship with cancer incidence and mortality 3 . Recent studies showed that hypertension is associated with non‐alcoholic fatty liver and imbalances of intestinal flora 4,5 .…”

Section: Introductionmentioning

confidence: 99%

Association between hypertension and pressure ulcer: A systematic review and meta‐analysis

Huang,

Zhou,

2024

International Wound Journal

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This review aims to systematically evaluate the association between hypertension and pressure ulcer (PU). PubMed, Embase, Web of Science, and Cochrane Library were searched for studies from their inception until September 12, 2023. Literature search, data extraction, and quality assessment were conducted independently by two researchers. The random‐effects model was used to calculate the combined odds ratio (OR) and corresponding 95% confidence interval (CI) of hypertension in patients with PU; subgroup analyses were performed to explore the source of between‐study heterogeneity; sensitivity analysis was used to test the robust of the combined result; and funnel plot and Egger's test were used to assess the publication bias. Finally, a total of 19 studies with 564 716 subjects were included; the overall pooled result showed no significant association between hypertension and risk of developing PU (OR = 1.15, 95% CI = 0.90–1.47, p = 0.27); and the sensitivity analysis and publication bias analysis showed robust of the combined result. Subgroup analysis indicated a significant association between hypertension and PU when the primary disease was COVID‐19 (OR = 1.73, 95% CI = 1.35–2.22, p < 0.0001). No association between hypertension and PU was seen in subgroup analysis on the patient source and study design. In sum, there is no significantly statistical association between hypertension and the occurrence of PU in most cases, while the risk of PU significantly elevates among COVID‐19 patients combined with hypertension regardless of patient source and study design.

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Hypertension and Alzheimer's disease pathology at autopsy: A systematic review

Cited by 22 publications

References 77 publications

Association of APP gene polymorphisms and promoter methylation with essential hypertension in Guizhou: a case–control study

Association of APP gene polymorphisms and promoter methylation with essential hypertension in Guizhou: a case–control study

Polymorphism of NOS3 gene and its association with essential hypertension in Guizhou populations of China

Association between hypertension and pressure ulcer: A systematic review and meta‐analysis

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