Hypertension and cochlear hearing loss

Przewoźny, Tomasz; Gójska-Grymajło, Anna; Kwarciany, Mariusz; Gąsecki, Dariusz

doi:10.3109/08037051.2015.1049466

Cited by 48 publications

(55 citation statements)

References 59 publications

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“…That may be the reason why individuals with CC genotype of rs1485175 in GRM7 are less susceptible to noise than non-CC genotype. CNE [ 6 ], height [ 32 ], smoking [ 33 ], drinking [ 34 , 35 ], and hypertension [ 35 ], which are all hazardous factors for NIHL, were adjusted in the process of analyzing.…”

Section: Discussionmentioning

confidence: 99%

Effect of GRM7 polymorphisms on the development of noise-induced hearing loss in Chinese Han workers: a nested case-control study

Jiao

Chen

et al. 2018

BMC Med Genet

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BackgroundNoise-induced hearing loss (NIHL) is a complex, irreversible disease caused by the interaction of genetic and environmental factors. In recent years, a great many studies have been done to explore the NIHL susceptibility genes among humans. So far, high powerful detections have been founded that genes of potassium ion channel genes (KCNQ4 and KCNE1), catalase (CAT), protocadherin 15 (PCDH15), myosin 14 (MYH14) and heart shock protein (HSP70) which have been identified in more than one population may be associated with the susceptibility to NIHL. As for metabolic glutamate receptor7 gene (GRM7), a lot of researches mainly focus on age-related hearing loss (ARHL) and the results have shown that the polymorphisms of GRM7 are linked to the development of ARHL. However, little is known about the association of GRM7 and the susceptibility to NIHL. Therefore, the aim of this study was to explore the effect of GRM7 polymorphisms on the susceptibility to NIHL.MethodsA nested case-control study based on the cohort in a Chinese steel factory was implemented in 292 cases and 584 controls matched with the same sex, the age difference ≤ 5 years old, the same type of work, duration of occupational noise exposure ≤2 years. Five single nucleotide polymorphisms (SNPs) of GRM7 were gained through selecting and genotyping SNPs. Conditional logistic regression analysis was used to assess the main effect of GRM7 polymorphisms on the susceptibility to NIHL and the gene-by-environment interaction. Furthermore, the gene-by-gene interactions were analyzed by generalized multiple dimensionality reduction (GMDR).ResultsThis research discovered for the first time that the mutant allele C in rs1485175 of the GMR7 may decrease individuals’ susceptibility to NIHL. The interaction between rs1485175 and cumulative noise exposure (CNE) at high level was found after the stratification according to CNE (p/pbon = 0.014/0.007, OR = 0.550, 95% CI: 0.340–0.891). Permutation test of GMDR suggested that rs1920109, rs1485175 and rs9826579 in GRM7 might interact with each other in the process of developing NIHL (p = 0.037).ConclusionsThe results suggest that the mutant allele C of rs1485175 in GRM7 may reduce the susceptibility to NIHL in Chinese Han population.Electronic supplementary materialThe online version of this article (10.1186/s12881-017-0515-3) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Effect of GRM7 polymorphisms on the development of noise-induced hearing loss in Chinese Han workers: a nested case-control study

Jiao

Chen

et al. 2018

BMC Med Genet

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“…Furthermore hypertension and diabetes often co-exists in same individual. 16,17 The relationship between hypertension and T2DM is complex. Hypertension may exert impact upon the onset of T2DM through increasing vasoconstriction and vascular rarefaction, reducing skeletal muscle insulin sensitivity and detecting post receptor insulin signalling.…”

Section: Discussionmentioning

confidence: 99%

Determinants of metabolic syndrome (MetS) amongst persons living in Dibrugarh District of Assam

Mahanta

Joshi

Mahanta

et al. 2017

Clinical Epidemiology and Global Health

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“…Tachibana et al [ 37 ] suggested that the primary target of hypertensive damage in the rat cochlea is the stria vascularis, which feeds the organ of Corti. Przewoźny et al [ 38 ] suggested that the subclinical damage to the stria vascularis includes the decrease in the cochlear oxygen partial pressure and disturbance of the ionic K + recycling. Borghi et al [ 34 ] suggested that the presence of tinnitus is the consequence of toxic damage of the labyrinth in most patients, which means that the onset of tinnitus might be an adverse event in patients treated with antihypertensive drugs.…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review and Meta-Analysis on the Association between Hypertension and Tinnitus

Pan

Zheng

et al. 2015

International Journal of Hypertension

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Hypertension has been suggested to be one possible risk factor of tinnitus, but the association between hypertension and tinnitus remains uncertain. The authors performed a meta-analysis of the existing studies on the association between hypertension and tinnitus. We performed literature search of studies using SinoMed, CNKI, WanFang, PubMed, Scopus, Web of Science, and Google Scholar. Studies reported the odds ratio and 95% confidence interval (CI) (or provided sufficient information for calculation) of the association between hypertension and tinnitus were included. A total of 19 eligible studies with 20 effect estimates were used in this study. They included 63,154 participants with age ranging from 14 to 92. The pooled OR, which was pooled using a random effects model, was 1.37 (95% CI: 1.16 to 1.62). There was no evidence of publication bias (p = 0.11 for Begg's test, p = 0.96 for Egger's test). By meta-regression, we found that study design may be one possible factor of heterogeneity. Sensitivity analysis found that the result was stable. This study suggests that hypertension might be one risk factor of tinnitus, and hypertension prevention and control might be helpful in preventing tinnitus.

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Hypertension and cochlear hearing loss

Cited by 48 publications

References 59 publications

Effect of GRM7 polymorphisms on the development of noise-induced hearing loss in Chinese Han workers: a nested case-control study

Effect of GRM7 polymorphisms on the development of noise-induced hearing loss in Chinese Han workers: a nested case-control study

Determinants of metabolic syndrome (MetS) amongst persons living in Dibrugarh District of Assam

A Systematic Review and Meta-Analysis on the Association between Hypertension and Tinnitus

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