Hypertension and coronary artery ectasia: a systematic review and meta-analysis study

Bahremand, Mostafa; Zereshki, Ehsan; Rezaei, Mansour; Omrani, Hamidreza

doi:10.1186/s40885-021-00170-6

Cited by 6 publications

(4 citation statements)

References 64 publications

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“…[ 18 , 19 ] Hypertension and smoking have been demonstrated to be associated with CAE. [ 20 , 21 ] In our research, the proportion of gender and smoking were similar in the 2 groups. In addition, BMI and IVSd were independent risk factors for CAE, which are similar to the previous studies.…”

Section: Discussionsupporting

confidence: 53%

Risk factors and major adverse cardiovascular events of isolated coronary artery ectasia: An observational study

Yang,

Zong,

Zhang

et al. 2024

Medicine

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To evaluate the cardiac index and major adverse cardiovascular events (MACE) events between isolated coronary artery ectasia (CAE) and control groups over 1 year period from diagnosis. A total of 18 patients who were diagnosed with isolated CAE in the Second Hospital of Hebei Medical University from December 2020 to December 2021 were included in CAE group. About 36 patients with non-obstructive coronary artery lesions were included in the control group. All patients in 2 groups completed dobutamine stress echocardiography (DSE) during hospitalization. The chamber size, wall thickness, left ventricular ejection fraction, and left ventricular diastolic function indicators (including E/A ratio, e’, and E/e’ ratio) were measured. MACE and all-cause death were measured during follow-up after discharge. Interventricular septum thickness (IVSd), left ventricular posterior wall (LVPW) thickness in diastole and E/e’ in CAE group were significantly higher than control group (P < .05). No significant differences were found in prognosis including angina, myocardial ischemia (MI), patient readmission and cardiovascular death (P > .05). In CAE group, coronary angiography showed dilation of left anterior descending (LAD) in 1 case, left circumflex (LCX) in 3 cases and right coronary artery (RCA) in 14 cases. Multivariate logistic regression analysis showed that BMI and IVSd were independent risk factors for CAE. IVSd, LVPW thickness in diastole and E/e’ in CAE group were significantly higher than control group. BMI and IVSd were independent risk factors for isolated CAE, and had a good predictive value for isolated CAE.

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Section: Discussionsupporting

confidence: 53%

Risk factors and major adverse cardiovascular events of isolated coronary artery ectasia: An observational study

Yang,

Zong,

Zhang

et al. 2024

Medicine

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“…Several reports showed a gender predominance with a high prevalence of CAE in men (1,18,19). Hypertension, smoking and dyslipidemia, including familial hypercholesterolemia, have also been associated with CAE (20)(21)(22). A higher risk of CAE was also reported among cocaine abusers (23).…”

Section: Epidemiologymentioning

confidence: 99%

Treatment and Outcome of Patients With Coronary Artery Ectasia: Current Evidence and Novel Opportunities for an Old Dilemma

Esposito

Maio

Silverio

et al. 2022

Front. Cardiovasc. Med.

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Coronary artery ectasia (CAE) is defined as a diffuse or focal dilation of an epicardial coronary artery, which diameter exceeds by at least 1. 5 times the normal adjacent segment. The term ectasia refers to a diffuse dilation, involving more than 50% of the length of the vessel, while the term aneurysm defines a focal vessel dilation. CAE is a relatively uncommon angiographic finding and its prevalence ranges between 0.3 and 5% of patients undergoing coronary angiography. Although its pathophysiology is still unclear, atherosclerosis seems to be the underlying mechanism in most cases. The prognostic role of CAE is also controversial, but previous studies reported a high risk of cardiovascular events and mortality in these patients after percutaneous coronary intervention. Despite the availability of different options for the interventional management of patients with CAE, including covered stent implantation and stent-assisted coil embolization, there is no one standard approach, as therapy is tailored to the individual patient. The abnormal coronary dilation, often associated with high thrombus burden in the setting of acute coronary syndromes, makes the interventional treatment of CAE patients challenging and often complicated by distal thrombus embolization and stent malapposition. Moreover, the optimal antithrombotic therapy is debated and includes dual antiplatelet therapy, anticoagulation, or a combination of them. In this review we aimed to provide an overview of the pathophysiology, classification, clinical presentation, natural history, and management of patients with CAE, with a focus on the challenges for both clinical and interventional cardiologists in daily clinical practice.

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“…Since that ACS presenters had a greater frequency of the illness, there was a statistically significant difference in hypertension between the two groups (P=0.004). Contrarily, in their analysis of 3263 people, Bahremand et al (16) observed no statistically significant in the prevalence of hypertension across the groups (P= 0.171).…”

Section: Anterior MImentioning

confidence: 88%

Relation between Coronary Artery Ectasia Characteristics and Development of Acute Coronary Syndrome

Ghanem

Neguib²,

Gad³

2023

The Egyptian Journal of Hospital Medicine

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Background: An aneurysmal aberration of the artery known as coronary artery ectasia (CAE) is identified by significant dilatation and a luminal diameter that is 1.5 times larger than the surrounding normal segments. As opposed to coronary artery aneurysms, which only have a little extension of the arterial wall, it is different. Managing acute coronary syndromes (ACS) in isolated CAE can be difficult because there is no proven therapy and little research in this area. Objective: To determine the predictors of ACS occurrence among patients with coronary ectasia especially ectatic segment characteristics. Patients and Methods: The present study included 272 patients with coronary ectasia and classified as follows: Group (A): presented with ACS (n=112, 41.2%) and group (B): presented with chronic coronary syndrome (CCS) (n=160, 58.8%). Age or gender had no statistically significant impact on the development of ACS in the patients under study. Results:The best cutoff of serum D-dimer level in diagnosis of ACS was ≥ 0.85 and those of serum uric acid level, LDL cholesterol, CRP and serum triglycerides were ≥7.3 mg/dl., ≥178 mg/dl., ≥7.6 mg/l. and ≥181.5 mg/dl, respectively. There was statistically non-significant relation between ACS development and the culprit coronary, but notably ectasia was more frequently affecting the right coronary artery (RCA). The best cutoff of ectatic segment length in predicting ACS was ≥39 mm with area under curve 0.7, sensitivity 64%, and specificity 88%. The best cutoff of ectatic segment diameter in predicting ACS was ≥6 mm with area under curve 0.8, sensitivity 74%, and specificity 65%. Conclusions: With the aid of noninvasive conventional and laboratory risk factors, we are able to anticipate the development of ACS in patients with coronary ectasia and may then recommend the best course of action for preventing ACS recurrence.

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Hypertension and coronary artery ectasia: a systematic review and meta-analysis study

Cited by 6 publications

References 64 publications

Risk factors and major adverse cardiovascular events of isolated coronary artery ectasia: An observational study

Risk factors and major adverse cardiovascular events of isolated coronary artery ectasia: An observational study

Treatment and Outcome of Patients With Coronary Artery Ectasia: Current Evidence and Novel Opportunities for an Old Dilemma

Relation between Coronary Artery Ectasia Characteristics and Development of Acute Coronary Syndrome

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