Hypertension and Depression and Their Treatment

Simpson, F. O.

doi:10.3109/00048677309159735

Cited by 17 publications

(2 citation statements)

References 35 publications

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“…The Medical Research Council Working Party on Mild to Moderate Hypertension (1981), which did not assess depression directly, reported high rates of lethargy associated with propranolol treatment, necessitating withdrawal from the trial in about 5% of cases. On the other hand, it has been noted that patients frequently fail to recognize symptoms of depression (Simpson, 1973), and one recent study (Schwartz, 1983) found that hypertensive patients are especially likely to repress unpleasant emotional feelings. This would suggest that the incidence of depressive side effects may be considerably higher than has been reported in most studies to date, underscoring the need for more objective assessment procedures.…”

Section: Depression As a Side Effect Of Antihypertensive Therapymentioning

confidence: 99%

Biobehavioral sequellae associated with adrenergic-inhibiting antihypertensive agents: A critical review.

Rosen¹,

Kostis²

1985

Health Psychology

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Adrenergic-inhibiting antihypertensive drugs, most notably the beta-blockers and alpha-agonists, have been shown to influence a variety of central nervous system (CNS) functions. In some instances the use of these drugs has also been reported to lead to serious psychiatric complications. Despite the clinical significance of these effects and the potential threat to treatment adherence the underlying mechanisms are poorly understood. This article critically evaluates the existing research in six major areas: (a) depression, (b) lethargy/fatigue, (c) cognitive and perceptual-motor performance, (d) quantitative electroencephalogram (EEG) changes, (e) sleep, and (f) sexual function. In general, the evidence suggests that a pseudo-depressive state may be a relatively common side effect of treatment, and that associated changes in cognitive, affective, sleep, and sexual function may be frequently encountered.

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Section: Depression As a Side Effect Of Antihypertensive Therapymentioning

confidence: 99%

Biobehavioral sequellae associated with adrenergic-inhibiting antihypertensive agents: A critical review.

Rosen¹,

Kostis²

1985

Health Psychology

View full text Add to dashboard Cite

show abstract

“…Patients with hypertension and depression can present considerable problems in therapy (Simpson, 1973). In handling such patients, it is essential first of all to make sure that the antihypertensive drugs are not causing or aggravating the depression.…”

Section: Tricyclic Antidepressantsmentioning

confidence: 99%