Hypertension and high hematocrit

Tarazi, Robert C.; Fröhlich, Edward D.; Dustan, Harriet P.; Gifford, Ray W.; Page, Irvine H.

doi:10.1016/0002-9149(66)90430-9

Cited by 51 publications

(5 citation statements)

References 10 publications

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“…Although polycythaemia due to renal artery stenosis seems to be infrequent [2], it has been described in animals [15] and in man [16]. Cases of stenosis affecting the artery of transplanted kidneys associated with polycythemia and high serum erythropoietin level have been reported [ 171, indicating that renal perfusion in some of these conditions may be of importance.…”

Section: Discussionmentioning

confidence: 99%

“…Reduced renal function is associated with insufficient erythropoietin production. Renal artery stenosis may result in an elevated serum level of erythropoietin-possibly due to intrarenal hypoxia-but only rarely gives rise to polycythaemia [ 2 ] . Animal experiments have shown that reduced renal blood flow can stimulate erythropoietin production [3,4].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Elevated level of erythropoietin in congestive heart failure Relationship to renal perfusion and plasma renin

Jensen¹,

Eiskjær²,

Bagger³

et al. 1993

Journal of Internal Medicine

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Elevated level of erythropoietin in congestive heart failure Relationship to renal perfusion and plasma renin

Jensen¹,

Eiskjær²,

Bagger³

et al. 1993

Journal of Internal Medicine

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“…The clinical and pathological conditions associated with increased renal production of eEPO include acquired cysts [1], adult polycystic kidney disease (APKD) [2], hydronephrosis [3], renal artery stenosis [4], tumors [5] and post-renal transplant erythropoiesis [6]. Although the kidney is the main eEPO-producing organ after birth, there are conditions in which extrarenal EPO production occurs, primarily in the liver.…”

Section: Introductionmentioning

confidence: 99%

Factors Related to the Absence of Anemia in Hemodialysis Patients

et al. 2011

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Background: A small number of hemodialysis (HD) patients have normal hemoglobin (Hb) levels without the need for erythropoiesis-stimulating agents (ESAs). The factors associated with this condition have been little studied. The objective of this prospective study was to determine these factors in a prevalent population of HD patients. Materials and Methods: All patients who had normal Hb levels and who had not received ESAs in the last 6 months (non-ESA group) were included. Epidemiological and laboratory data were collected and we performed an abdominal ultrasound to assess hepatic and renal cysts. This group was compared to a control group of 205 prevalent HD patients on ESA therapy (control group). Results: We included 45 patients (16% from the whole group) in the non-ESA group. In this group, there was a higher proportion of men (76.5 vs. 61%), patients were younger (61.1 ± 14.7 vs. 67.5 ± 15.2 years), had a longer duration of renal replacement therapy (RRT) (9.4 ± 8.3 vs. 5.3 ± 5.8 years) and had a higher prevalence of adult polycystic kidney disease (APKD) and hepatitis C virus (HCV) liver disease (42.2 vs. 10.2%), p < 0.01. In the non-ESA group, HCV+ patients had a lower prevalence of APKD (2.2 vs. 38.4%) and hepatic cysts (2.2 vs. 19.2%), but significantly higher endogenous erythropoietin levels (55.8 ± 37.1 vs. 30.9 ± 38.4 mU/ml). No significant differences in anemia, iron metabolism, insulin, IGF-1 and renin were found between non-ESA and control groups. Non-ESA patients had a significantly higher number of renal (90.6 vs. 36.5%) and hepatic cysts (12.5 vs. 3.4%), and these were also larger in size (3.3 ± 2.4 vs. 1.5 ± 0.8 cm). In the multivariate Cox analysis, independent predictor factors for absence of anemia in HD patients were number of renal cysts >10 cysts (95% CI 1.058–1.405; p = 0.00), HCV+ liver disease (95% CI 1.147–1.511; p = 0.05) and time on RRT (95% CI 1.002–1.121; p = 0.05). Conclusions: The absence of anemia in HD patients is not infrequent. Its frequency is higher in men and younger patients with long-term RRT, in patients with HCV+ liver disease and in APKD. It is associated with increased endogenous erythropoietin production and the presence of renal and hepatic cysts.

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“…Erythrocytosis has been reported in patients with extrarenal [10][11][12] or intrarenal [13] artery stenosis. In these cases, the in creased red blood cell production is probably secon dary to renal tissue hypoxia.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand erythrocytosis may be associated with various renal diseases such as benign and malignant tumors of the kidney [1], hydronephrosis [2], simple cysts [3], multicystic kidney disease [4], polycystic kidney dis ease (PKD) [5][6][7][8][9], renal artery stenosis [10][11][12][13], diffuse parenchymal disease [14] and following renal trans plantation [15,16]. However, it has rarely been re ported in patients receiving intermittent hemodialy sis, and mainly in those patients who developed acquired cystic disease [17], Herein we report the development of erythrocyto sis associated with renal artery thrombosis in a pa tient with PKD on hemodialysis.…”

Section: Introductionmentioning

confidence: 99%

Erythrocytosis Associated with Renal Artery Thrombosis in a Patient with Polycystic Kidney Disease on Hemodialysis

et al. 1990

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We report a case of erythrocytosis in a patient with end-stage renal failure on chronic hemodialysis. The patient with polycystic kidney disease had an average Hb level of 10 g/dl while on hemodialysis for 3 years. He developed erythrocytosis (Hb 17.6 g/dl) following a cadaveric renal transplantation. No signs suggesting polycythemia vera were found. Nonrenal causes of secondary erythrocytosis such as anoxia, hemoglobinopathies or tumors were excluded. Angiography showed renal artery occlusion of the native kidney. Serum erythropoietin level was 85 U/l (normal 52 ± 31 U/l) as measured by ³H-thymidine uptake. It is suggested that ischemia caused by the renal artery thrombosis stimulated the erythropoietin production in the native polycystic kidney.

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Hypertension and high hematocrit

Cited by 51 publications

References 10 publications

Elevated level of erythropoietin in congestive heart failure Relationship to renal perfusion and plasma renin

Elevated level of erythropoietin in congestive heart failure Relationship to renal perfusion and plasma renin

Factors Related to the Absence of Anemia in Hemodialysis Patients

Erythrocytosis Associated with Renal Artery Thrombosis in a Patient with Polycystic Kidney Disease on Hemodialysis

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