Hypertension and Histopathology Severity of Non-Alcoholic Fatty Liver Disease Among Adults with Obesity: A Cross-Sectional Study

Chambergo‐Michilot, Diego; Rodrigo-Gallardo, Paola K.; Huaman, Mariella R.; Vasquez-Chavesta, Angie Z.; Salinas-Sedo, Gustavo; Toro-Huamanchumo, Carlos J.

doi:10.2147/ceg.s402498

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…Moreover, this risk is independent of other cardiovascular risk factors or amount of cardiac arterial stenosis. 84 There is also an association between hypertension and steatosis, 85 and steatosis is a predictor of mortality in acute myocardial infarction with hepatic fibrosis having only a slightly increased risk of mortality compared with steatosis. 86 Finally, steatosis more than 30% predicts graft failure when steatotic livers are transplanted.…”

Section: Ld Effects On Hepatic Morphology In Mashmentioning

confidence: 99%

Mechanisms of Lipid Droplet Accumulation in Steatotic Liver Diseases

Dempsey,

Ioannou,

Carr

2023

Semin Liver Dis

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The steatotic diseases of non-alcoholic fatty liver disease, alcohol-associated liver disease and chronic Hepatitis C account for the majority of liver disease prevalence, morbidity and mortality worldwide. While these diseases have distinct pathogenic and clinical features, dysregulated lipid droplet (LD) organelle biology represents a convergence of pathogenesis in all three. With increasing understanding of hepatocyte LD biology, we now understand the roles of LD proteins involved in these diseases but also how genetics modulate LD biology to either exacerbate or protect against the phenotypes associated with steatotic liver diseases. Here, we review the history of the LD organelle and its biogenesis and catabolism. We also review how this organelle is critical not only for the steatotic phenotype of liver diseases but also for their advanced phenotypes. Finally, we summarize the latest attempts and challenges of leveraging LD biology for therapeutic gain in steatotic diseases. In conclusion, the study of dysregulated LD biology may lead to novel therapeutics for the prevention of disease progression in the highly prevalent steatotic liver diseases of MASLD, ALD and HCV.

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Section: Ld Effects On Hepatic Morphology In Mashmentioning

confidence: 99%

Mechanisms of Lipid Droplet Accumulation in Steatotic Liver Diseases

Dempsey,

Ioannou,

Carr

2023

Semin Liver Dis

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Metabolic Dysfunction-Associated Steatotic Liver Disease in Japan: Prevalence Trends and Clinical Background in the 10 Years before the Coronavirus Disease 2019 Pandemic

Sato,

Oomori,

Nakano

et al. 2024

Medicina

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Background and Objectives: The trends in metabolic dysfunction-associated steatotic liver disease (MASLD) and related metabolic dysfunctions in Japan are unknown. Thus, we aimed to clarify these trends before the novel coronavirus disease 2019 pandemic in Japan. Materials and Methods: We included Japanese individuals aged 25–79 years who underwent health examinations at our center. We analyzed anthropometry, lifestyle-related disease, and nutritional intake in relation to MASLD trends from 2010–2019. Results: The prevalence of MASLD increased in all ages and body mass index (BMI) classes, reaching 30.3% in males and 16.1% in females, with MASLD accounting for 75% of steatotic liver cases and more than half of all type 2 diabetes mellitus (T2DM) and high waist circumference (HWC) cases. The increase in the prevalence of MASLD was thought to be largely attributable to an increase in that of the incidence of steatotic liver itself, and there was no increase in the prevalence of other factors, such as overweight, T2DM, hypertension, and dyslipidemia. The prevalence of glucose metabolic disorders (GMDs) and hypertension decreased. National nutritional data showed an increase in energy intake, total fat, saturated fatty acids, monounsaturated fatty acids, and polyunsaturated fatty acids, which correlated with a decrease in GMDs. Salt intake also decreased, which correlated with hypertension. The MASLD group had a higher prevalence of all related metabolic factors than the non-MASLD group, especially HWC, T2DM, and hyperlipidemia. Conclusions: The prevalence of MASLD increased with that of steatotic liver, regardless of age or BMI. A relationship between increased dietary fat, increased steatotic liver, and decreased GMDs was suggested.

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Hypertension and Histopathology Severity of Non-Alcoholic Fatty Liver Disease Among Adults with Obesity: A Cross-Sectional Study

Cited by 2 publications

References 28 publications

Mechanisms of Lipid Droplet Accumulation in Steatotic Liver Diseases

Mechanisms of Lipid Droplet Accumulation in Steatotic Liver Diseases

Metabolic Dysfunction-Associated Steatotic Liver Disease in Japan: Prevalence Trends and Clinical Background in the 10 Years before the Coronavirus Disease 2019 Pandemic

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