Hypertension and Hyperuricæmia

Breckenridge, AM

doi:10.1016/s0140-6736(66)90005-5

Cited by 189 publications

(54 citation statements)

References 26 publications

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“…4.0 years, range 90-108 years) and 563 (68%) were women, including 81 centenarians. A total of 90% of subjects lived in the countryside.…”

Section: Resultsmentioning

confidence: 99%

“…1 The concept that uric acid may be involved in hypertension is not a new one, which has been reported more than a century ago. [2][3][4][5] More than a dozen of prospective and cross-sectional observational studies have demonstrated that the elevated serum uric acid (SUA) is a potential independent risk factor for the development of hypertension in the general population. [6][7][8][9][10][11][12][13][14][15][16][17][18][19] Common to each of these studies, however, is the relatively young age of the participants.…”

Section: Introductionmentioning

confidence: 99%

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Serum uric acid level in primary hypertension among Chinese nonagenarians/centenarians

Dong

He-ping

et al. 2008

J Hum Hypertens

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Epidemiologic studies suggest an independent positive association of elevated serum uric acid with essential hypertension. However, to date, limited information is available in the old population. In the present study, we included 832 unrelated Chinese nonagenarians/centenarians (269 men and 563 women; ranged in age from 90 to 108 years (mean, 94.6±4.0)). The mean serum uric acid level was 320 lmol l À1 (standard deviation 87 lmol l À1). After adjustment for age, body mass index, waist-to-hip ratio, smoking habits, tea habits, alcohol consumption, fasting plasma glucose, plasma lipids and serum creatinine, the odds ratio comparing the highest with lowest quartile of serum uric acid were 0.67 (95% confidence interval (CI), 0.33-1.21) and 1.36 (95% CI, 0.88-2.22) in men and women, respectively. When compared with normotensive subjects, we did not observe statistical higher serum uric acid levels in subjects with hypertension. In summary, we found that serum uric acid level is not directly correlated with hypertension among Chinese nonagenarians/centenarians.

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“…4.0 years, range 90-108 years) and 563 (68%) were women, including 81 centenarians. A total of 90% of subjects lived in the countryside.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum uric acid level in primary hypertension among Chinese nonagenarians/centenarians

Dong

He-ping

et al. 2008

J Hum Hypertens

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“…The high incidence of hyperuricemia to hypertension (1,2) has required the develop ment of a new generation of diuretic anti hypertensives, which do not cause hyper uricemia. Uricosuric diuretics such as tienilic acid (3) and indacrinone (4) have recently been studied as such candidates.…”

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confidence: 99%

A new diuretic that does not reduce renal handling of uric acid in rats, S-8666.

et al. 1987

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Abstract-The uric acid-retaining effects of diuretics were studied using sodium restricted spontaneously hypertensive rats. Test agents were administered orally once a day for two weeks.Diuretic thiazides such as trichlormethiazide and hydrochlorothiazide and loop diuretics such as furosemide and indacrinone clearly reduced the renal function for uric acid excretion in treatment which produced major effects such as diuresis, saluresis and hypotension.However, a new diuretic with uricosuric activity, S-8666, developed in our laboratories, had no effect on the renal handling of uric acid at doses which showed major effects similar to those of other diuretics.The results should aid the understanding of the utility of S-8666 as a new diuretic antihypertensive which does not cause hyperuricemia during therapy.

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“…(1) suggested that epinephrine, norepinephrine and angiotensin-II were inducers of hyper uricemia because of their renal vasoconstricting actions, and further clinical studies showed a striking association between hyperuricemia and hypertension (10,11). Recently, Wallace (12) reported increases of renin and catecholamine in the blood of patients with gout after salt-loading.…”

Section: Discussionmentioning

confidence: 99%

Stimulation by Catecholamine of Purine Catabolism in Rats and Chickens

Yonetani

Ishii

Ogawa

1979

Japanese Journal of Pharmacology

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Abstract-The effect of catecholamine in vivo was studied on purine catabolism in rats and chickens. Catecholamine, administered intraperitoneally in a high dose, markedly increased plasma uric acid and allantoin in rats, and an increase was also observed with intravenous infusion of a lower dose of catecholamine.The effects of catechol amine were characterized by inhibition with alpha and beta adrenoceptor antagonists. Regarding the mechanism of this catecholamine action on purine catabolism, it was shown that catecholamine stimulated degradation of tissue ATP into the end-product. Plasma allantoin, the final purine catabolite in rats, elicited by catecholamine could be maintained under conditions of renal failure, although the action of catecholamine in intact rat was short lasting. The effect of catecholamine was potentiated and/or prolonged by angiotensin-II and aminophylline, and a hyperuricemic state could be induced by catecholamine treatment in chickens. In addition, increase of plasma purine catabolite by immobilization stress in rats suggested the involvement of en dogenous catecholamine.From these experimental results, it is considered that catecholamines probably play a important role in the pathogenesis of hyperuricemia.The effect of catecholamine on purine catabolism in vivo has apparently not yet been reported in detail. Demartini (I) described that uric acid clearance in man may be reduced by the renal vasoconstricting action of alpha adrenoceptor agonists, and warned about their role in the induction of hyperuricemia. However, he provided no evidence that hyper uricemia was directly related to catecholamine. We recently demonstrated a notable increase of plasma uric acid in rats given intraperitoncal administration of epinephrine, and inhibition of the increase by the pretreatment with alpha adrenoceptor antagonists (2). Further, it was suggested that the increase of plasma uric acid was due to the rapid breakdown of hepatic and intestinal ATP rather than the renal vasoconstriction (3), and that the increase of plasma purine catabolites was also caused by the action of beta adrenoceptor agonists.The present paper is a report of our studies on the stimulation of purine catabolism by eatecholamine. MATERIALS AND METHODSSeven week-old male Wistar rats were housed in metal cages with sawdust as bedding and were maintained on a solid diet CA-1 (Japan CLEA Co., Tokyo) and tap water ad lihiturn. The room was air-conditioned, kept at a temperature of 25--2 °C with a relative humidity of 55,15 , and was lighted artificially from 6:00 to 18:00. Mechanical ventilation of the room was set at the rate of twelve changes per hour. The rats were decapitated, and blood was collected in heparinized centrifuge tubes and kept in an ice bath. In experiments using rats with ligated ureters, the operation was performed under deep anesthesia with 65 mg/kg of pentobarbital i.p. The infusion of agents was carried out in the anesthetized animals through the femoral vein. The method for applying immobili zation stress was a...

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Hypertension and Hyperuricæmia

Cited by 189 publications

References 26 publications

Serum uric acid level in primary hypertension among Chinese nonagenarians/centenarians

Serum uric acid level in primary hypertension among Chinese nonagenarians/centenarians

A new diuretic that does not reduce renal handling of uric acid in rats, S-8666.

Stimulation by Catecholamine of Purine Catabolism in Rats and Chickens

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