Hypertension and Migraine in the Northern Manhattan Study

Gardener, Hannah; Monteith, Teshamae; Rundek, Tatjana; Wright, Clinton B.; Elkind, Mitchell S.V.; Sacco, Ralph L.

doi:10.18865/ed.26.3.323

Cited by 37 publications

(41 citation statements)

References 32 publications

(35 reference statements)

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“…We found hypertension to be significantly associated with MH, consistent with multiple studies [3, 22, 23] including one based on self-report [24]. The North Manhattan Study found an association of hypertension with migraine [23]; however, their population was predominantly Hispanic and older than our population.…”

Section: Discussionsupporting

confidence: 89%

Migraine and Headache Prevalence and Associated Comorbidities in a Large Saudi Sample

et al. 2018

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Background: We aimed to assess the prevalence of headache and migraine, along with comorbidities, in a large Saudi sample. Methods: Self-reported information was collected about headache, migraine and migraine comorbidities including depression, restless legs syndrome (RLS), syncope, bruxism, hypertension and ischaemic disease. The OR was estimated using logistic regression for any associations with headache and migraine. We then analyzed to find a trend of increasing migraine symptoms for each significant comorbidity. Results: Out of 4,943 respondents, 4,158 (84.12%) had recurring headaches. Migraine was present in 1,333 (26.97%), with female predominance (ratio of 1: 2.9). There were statistically significant ORs between migraine and female sex, current smokers, higher income, hypertension, depression, syncope, RLS and bruxism. Non-migraine headaches were significantly associated with female sex, age, RLS and ischaemic disease. Migraine with aura was significantly associated with syncope, ischaemic disease, higher income and BMI. There was an overall significant trend of increasing migraine features in the presence of depression, syncope, RLS, bruxism and hypertension. Conclusions: Headache in general and migraine in particular are associated with multiple comorbidities in comparison to non-headache participants in our cohort, with an estimated prevalence similar to that of western countries.

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Section: Discussionsupporting

confidence: 89%

Migraine and Headache Prevalence and Associated Comorbidities in a Large Saudi Sample

et al. 2018

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“…For example available evidence reported that the odds of migraine is increased in obese individuals (15,48). Moreover, although there is controversial evidence regarding the association between hypertension and migraine, several ndings delineated that long duration and uncontrolled hypertension, especially systolic blood pressure, may have a positive link with migraine with/without aura (49,50).…”

Section: Discussionmentioning

confidence: 99%

The association between dietary acid load and the migraine odds

Mousavi

Jahromi

Togha

et al. 2020

Preprint

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Background: According to previous evidence, it has been shown that high acidic load in human body could affect inflammatory factors and the nitric oxide pathway. On the other hand, these factors are thought to play a role in initiation of migraine attacks. Therefore, we aimed to explore the association between dietary acid load and the odds of migraine in a case-control study.Methods: The migraine group (n=514, diagnosed according to the ICHDIII criteria) was recruited from a tertiary headache clinic. The controls consisted of 582 sex-matched healthy volunteers who were randomly selected from the general population. For dietary intake assessments, we used a validated 168-item semiquantitative food frequency questionnaire (FFQ). Using three different measures, such as potential renal acid load (PRAL), net endogenous acid production (NEAP), and protein /potassium ratio for estimation of the dietary acid load.Results: According to multivariable logistic regression analysis, in comparison with the lowest tertile, highest tertile of dietary acid load measures including PRAL (OR=7.208, 95% CI 3.33– 15.55), NEAP (OR=4.108, 95% CI 1.924– 8.774), protein/potassium ratio (OR=4.127, 95% CI 1.933– 8.814) were shown to significantly increase odds of migraine (P for trend= <0.001).Conclusions: In this study, it was found that high dietary acid load may be associated with higher odds of migraine. Consequently, restricting dietary acid load could be beneficial in reducing the odds of developing migraine in susceptible subjects.

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“…Gardener и соавт. [31] представили результаты многоцентрового популяционного исследования NOMAS (The Northern Manhattan Study), в котором приняли участие 1338 человек (средний возраст 68,1±9, 6 лет, 80% пациентов без мигрени, 6% с мигренью с аурой и 15% -с мигренью без ауры). АГ имела место у 76% обследуемых, длительность заболевания была различной, также были включены пациенты как с контролируемой АГ (достигнуты целевые уровни АД), так и с неконтролируемой АГ.…”

Section: взаимосвязь между мигренью и агunclassified

“…К основным патогенетическим механизмам и мигрени, и АГ относится также гиперсимпатикотония, что также объясняет взаимосвязь между этими двумя заболеваниями [31]. Косвенным подтверждением этой гипотезы является эффективность бета-адреноблокаторов (пропранолола, метопролола) в профилактике приступов мигрени, которые снижают симпатический тонус за счет блокады бета-адренорецепторов [39].…”

Section: взаимосвязь между мигренью и агunclassified

Hypertension and Headache: the Effect of Antihypertensive Drugs

Parfenov

Остроумова

2019

Racionalʹnaâ farmakoterapiâ v kardiologii

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Headache is considered to be one of the main symptoms of arterial hypertension (HT). Complaints of headache are presented by many patients with HT: from 44% to 87%. It is obvious that the majority of complaints of headache in patients with HT is not due to headaches due to increased blood pressure (BP), but multimorbidity (polymorbidity) – the presence of coexisting primary headaches, most often, as in the population as a whole, chronic tension headache (57-85%) and migraine (15-30%). On the other hand, the frequency of HT in patients with migraine ranges from 32% to 44%. The relationship between migraine and HT may be due to common exogenous (external) and endogenous (genetic) factors, as well as common pathophysiological mechanisms. External risk factors, which can be associated with both migraine and HT, include the nature of the diet (excessive consumption of table salt with food), low physical activity, chronic stress; both diseases are also associated with the presence of a connection with the metabolic syndrome. The role of hyperactivation of the renin-angiotensin-aldosterone and adrenergic system and endothelial dysfunction are actively discussed. Angiotensin-converting enzyme takes an active part in the BP control and vascular tone; it is known that some angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) have demonstrated efficacy in preventing migraine attacks. The presence of HT can contribute to the chronic course of primary headache, and effective treatment of HT with antihypertensive drugs, on the contrary, can have a positive effect on the course of primary headaches. Antihypertensive drugs reduce the frequency of headaches compared to placebo, but heterogeneity between different classes was revealed. There was a statistically significant decrease in the frequency of headaches compared to placebo during treatment with beta-blockers, ACEI, ARB, diuretics, while calcium antagonists did not reduce the frequency of headaches. According to a number of studies, the frequency of headaches during the treatment with ARB (candesartan) is comparable to that in the placebo group. Some antihypertensive drugs are used to prevent migraine attacks.

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Hypertension and Migraine in the Northern Manhattan Study

Abstract: Conclusion:Hypertension, particularly uncontrolled and of long duration, is associated with migraine, both with and without aura, in a predominantly Hispanic community-based cohort. Ethn

Cited by 37 publications

References 32 publications

Migraine and Headache Prevalence and Associated Comorbidities in a Large Saudi Sample

Migraine and Headache Prevalence and Associated Comorbidities in a Large Saudi Sample

The association between dietary acid load and the migraine odds

Hypertension and Headache: the Effect of Antihypertensive Drugs

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