2003
DOI: 10.1016/s0014-4886(03)00274-7
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Hypertension and neuronal degeneration in excised rat spinal cord studied by high-b value q-space diffusion magnetic resonance imaging

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Cited by 31 publications
(24 citation statements)
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“…42 The qspace MDP was signiˆcantly higher in the white matter of the SPSHR group than the control group. Electron microscopy also showed signiˆcant demyelination in the spinal cords of the SPSHR.…”
Section: Cerebral Ischemiamentioning
confidence: 88%
“…42 The qspace MDP was signiˆcantly higher in the white matter of the SPSHR group than the control group. Electron microscopy also showed signiˆcant demyelination in the spinal cords of the SPSHR.…”
Section: Cerebral Ischemiamentioning
confidence: 88%
“…Due to the nonmono-exponential nature of the water signal decay at high b-values, different approaches to it's analysis were developed [21,23,26,27], including the q-space approach [28], originally developed by Cory and Callaghan [29,30]. Indeed, high b-value q-space DWI was used to study WM maturation [31], degeneration [32], and spinal cord trauma [33]. For example, diffusion images, when analyzed using the q-space approach, show areas of abnormal WM in multiple sclerosis (MS) not detected by other MRI methods like T 2 -, T 1 -weighted imaging, FLAIR, and DTI [34,28].…”
Section: Introductionmentioning
confidence: 99%
“…At a given diffusion time a tall, narrow PDF suggests a low diffusion constant and/or restricted diffusion, whereas a low, broad PDF suggests a high diffusion constant and/or more unrestricted diffusion. Q-space analysis allows experimental determination of the PDF and has been used in animal models to study the effects of reduced blood flow (28), myelin development (29), WM damage due to crush injury (30), myelin deficiency (31), and hypertension-induced neurodegeneration (32). Structural information derived from q-space DWI in fixed rat spinal cords has also correlated well with axon diameters obtained from histological examination (33).…”
mentioning
confidence: 98%