Hypertension and non‐alcoholic fatty liver disease proven by transient elastography

Wang, Yaohui; Zeng, Yuehua; Lin, Changwei; Chen, Zhiheng

doi:10.1111/hepr.12688

Cited by 38 publications

(37 citation statements)

References 34 publications

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“…Recently, Wang et al demonstrated that NAFLD is independently associated with hypertension and blood pressure category [33]. In this study, the CAP value was the predictor of diastolic, but not systolic BP in stepwise analysis for the whole study group, not only in NAFLD participants [33]. Of note, CAP alone was not sufficient for predicting hypertension in this study.…”

Section: Discussioncontrasting

confidence: 60%

“…Even more importantly, fatty liver was shown to be associated with 24-h systolic blood pressure and daytime diastolic blood pressure measurements [24]. Recently, Wang et al demonstrated that NAFLD is independently associated with hypertension and blood pressure category [33]. In this study, the CAP value was the predictor of diastolic, but not systolic BP in stepwise analysis for the whole study group, not only in NAFLD participants [33].…”

Section: Discussionmentioning

confidence: 45%

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Changes in Office Blood Pressure Control, Augmentation Index, and Liver Steatosis in Kidney Transplant Patients after Successful Hepatitis C Infection Treatment with Direct Antiviral Agents

Kolonko

Musialik

Chudek

et al. 2020

JCM

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Hepatitis C virus (HCV) infection in kidney transplant recipients (KTRs) can be successfully treated with direct antiviral agents (DAA). The aim of our study was to analyze different measures of vascular function during and after the DAA treatment. As we have observed the improvement of blood pressure (BP) control in some individuals, we have conducted an analysis of potential explanatory mechanisms behind this finding. Twenty-eight adult KTRs were prospectively evaluated before and 15 months after start of DAA therapy. Attended office BP (OBP), augmentation index (AIx), pulse wave velocity (PWV), flow-mediated dilation (FMD), liver stiffness measurement (LSM), and liver steatosis assessment (controlled attenuation parameter (CAP)) were measured. In half of the patients, improvement of OBP control (decline of systolic BP by at least 20 mmHg or reduction of the number of antihypertensive drugs used) and parallel central aortic pressure parameters, including AIx, was observed. There was a significant decrease in CAP mean values (241 ± 54 vs. 209 ± 30 dB/m, p < 0.05) only in patients with OBP control improvement. Half of our KTRs cohort after successful HCV eradication noted clinically important improvement of both OBP control and central aortic pressure parameters, including AIx. The concomitant decrease of liver steatosis was observed only in the subgroup of patients with improvement of blood pressure control.

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Section: Discussioncontrasting

confidence: 60%

Section: Discussionmentioning

confidence: 45%

Changes in Office Blood Pressure Control, Augmentation Index, and Liver Steatosis in Kidney Transplant Patients after Successful Hepatitis C Infection Treatment with Direct Antiviral Agents

Kolonko

Musialik

Chudek

et al. 2020

JCM

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show abstract

“…Recent reports have also indicated that hypertension is associated with NAFLD as metabolic syndrome. 28 Insulin resistance raises blood pressure through the activation of the sympathetic nerve system (SNS) 29 and the renin-angiotensin system (RAS). 30 The up-regulation of SNS and RAS induces liver fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Risk Assessment of Hepatocellular Carcinoma in General Population by Liver Stiffness in Combination with Controlled Attenuation Parameter using Transient Elastography: A Cross Sectional Study

et al. 2017

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Background Hepatocellular carcinoma (HCC) in patients without hepatitis B (HBV) and-C virus (HCV) infection are increasing in Japan. Method for detecting high-risk liver diseases of HCC in general population has still not been established. Liver stiffness measurement (LSM) and Controlled Attenuation Parameter (CAP) using transient elastography (TE; FibroScan System) are useful for detecting liver fibrosis and steatosis. The aim of this study is to clarify TE for risk assessment of HCC in general population. Methods This cross-sectional study was performed for residents aged ≥ 40 years in an intermountain town in Japan with a population of 3,493. Blood laboratory testing included tumor markers, abdominal ultrasound (AUS), and TE was performed. Results Among 175 subjects (64 men, 111 women), TE was evaluated and three patients with HCC were detected by AUS. For detecting HCC, the cutoff value of LSM was 5.3 kPa sensitivity 100%, specificity 75%, AUROC 0.88). The combination of LSM and CAP (LSM > 5.3 kPa with any CAP and CAP > 248 dB/m with any LSM) could detect the high-risk liver diseases of HCC (HCC, nonalcoholic fatty liver/steatohepatitis, HBV or HCV related chronic viral hepatitis with alanine transaminase (ALT) > 30 IU/L for men or > 19 IU/L for women or cirrhosis of any cause) with high sensitivity (sensitivity 90%, specificity 55%, positive predictive value 10%, negative predictive value 99%, P = 0.006). Conclusion The combination of LSM and CAP can be useful in detecting high-risk liver diseases of HCC out of general population.

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“…[10] Another recent study shows that hypertensive patients have a greater extent of prevalence in NAFLD and it is independently associated with hypertension and blood pressure category. [11] …”

Section: Hypertension and Nafldmentioning

confidence: 99%

Impact of Co-Morbidities in Non Alcoholic Fatty Liver Disease among Type 2 Diabetes Mellitus

2017

IJSR

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Non-alcoholic liver disease(NAFLD) is a common liver disorder which is closely associated with insulin resistance and type 2 diabetes mellitus and it is characterised by fat accumulation in the liver.The prevalence in diabetic population is found to be 20-40%. Studies have shown that NAFLD is strongly associated with severalmetabolic disordersand diseases, such as obesity, type 2 diabetes mellitus,and dyslipidemia. This review article aim to check the association of co-morbidities in non-alcoholic fatty liver among type 2diabetes mellitus. NAFLD deserves particular attention given that NAFLD could be a risk factor for the development of metabolic syndrome, CVD, and CKD.

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Hypertension and non‐alcoholic fatty liver disease proven by transient elastography

Abstract: The main finding of our study is that hypertensive patients have a higher prevalence of NAFLD defined by TE, and NAFLD is independently associated with hypertension and blood pressure category.

Cited by 38 publications

References 34 publications

Changes in Office Blood Pressure Control, Augmentation Index, and Liver Steatosis in Kidney Transplant Patients after Successful Hepatitis C Infection Treatment with Direct Antiviral Agents

Changes in Office Blood Pressure Control, Augmentation Index, and Liver Steatosis in Kidney Transplant Patients after Successful Hepatitis C Infection Treatment with Direct Antiviral Agents

Risk Assessment of Hepatocellular Carcinoma in General Population by Liver Stiffness in Combination with Controlled Attenuation Parameter using Transient Elastography: A Cross Sectional Study

Impact of Co-Morbidities in Non Alcoholic Fatty Liver Disease among Type 2 Diabetes Mellitus

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