Hypertension and Progression of Renal Failure in Patients on Protein-Restricted Diet

Role of Hypertension on the Progression of Renal Disease in Man

“…In addition, hypertension was signif icantly more frequent than normotension in those patients who had an 'accelerated' dete rioration of their renal function, and the mean arterial pressure levels were higher in patients with continued loss of renal func tion than in those with stability of renal fail ure. Thus, this larger study supports our pre liminary data showing that hypertension is associated with a more evident loss of renal function in patients with early CRF [19].…”

Permissive role of hypertension in the development of proteinuria and progression of renal disease in insulin-dependent diabetic patients

“…We found a correlation with hypertension as a categorical variable but no association with actual blood pressure levels and the rate of decline in renal function. In a retrospective study of the progression of chronic renal disease (30% due to diabetes) it was found that maintaining a diastolic blood pressure of < 90 mmHg was associated with the slowest rates of decline in renal function [22]. This is consistent with earlier studies that did not show a relationship between the rate of decline in renal function and systemic blood pressure when patients with chronic renal disease of various causes were treated [21].…”

Diastolic Blood Pressure and Progression of Chronic Renal Failure

“…On the other hand. Oldrizzi et al [3] showed that the mean blood pressure did not affect the progression of renal failure.A recent paper by Brazy et al [4] confirmed that a diastolic (but not systolic or mean) blood pressure of less than 90 mm Hg was associated with a slower rate of progression to end-stage renal disease.In this context, the study by Eliahou et al[5] is of interest; they reported a favorable effect of the calcium channel blocker nisoldipine on the progression of renal failure. These authors stressed the beneficial effect of other factors rather than blood pressure control because no significant difference in the reduction of systolic blood pressure was observed between the nisoldipinetreated group and the group treated with placebo/standard antihypertensives.…”

“…Japan Dear Sir, An increase in blood pressure has been considered as one of the factors which may contribute to the progres sion of chronic renal failure in patients with renal disease [1][2][3][4][5]. However, it has not been discussed in detail which blood pressure, i.e.…”