Hypertension and tissue metal levels following intravenous cadmium, mercury, and zinc

Hm, Perry; Yunice, Aniece A.; Erlanger, M; Schoepfle, E; Ef, Perry

doi:10.1152/ajplegacy.1970.219.3.755

Cited by 42 publications

(7 citation statements)

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“…Cadmium has been reported to produce acute as well as chronic hypertension in experimental animals (Perry & Yunice, 1965;Perry, Erlanger, Yunice, Schoepfle & Perry, 1970;Schroeder, 1964Schroeder, ,1967Thind, Karreman, Stephan & Blakemore, 1970;Thind, 1973). Conceivably augmentation by Cd of sympathetic post-ganglionic discharges, as found in the present study, could contribute to the development of hypertension.…”

Section: Discussionsupporting

confidence: 70%

Effects of divalent cations and of catecholamines on the late response of the superior cervical ganglion.

Chen¹

1975

The Journal of Physiology

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The characteristics of the late response of the superior cervical ganglion of dogs were studied by close‐arterial injection of catecholamines and divalent cations to the ganglion. 2. Dopamine, noradrenaline and adrenaline inhibit the late response as well as ganglionic activity induced by other means. The effect of dopamine is brief but that of adrenaline is prolonged. 3. Cd2+, Co2+, Ni2+, Zn2+, Hg2+ and Fe2+ markedly potentiate the late response, whereas Mn2+, Ca2+ and Mg2+ inhibit it. 4. may potentiate ganglionic activity triggered by other ganglionic stimulants. The Cd‐augmented activity may be blocked by a ganglion‐blocker which is specific to the stimulant. 5. CdCl2 may exhibit a direct ganglion‐stimulating action on a ganglion which shows prominent late responses and has been conditioned by tetanic preganglionic stimulation. 6. CdCl2 and MnCl2 may inhibit ganglionic transmission by suppressing acetylcholine release from presynaptic nerve terminals. 7. It is concluded that the late response represents the late discharges of ganglion cells, which are very sensitive to inhibition by CaCl2 and MnCl2 and may be potentiated by CdCl2.

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Section: Discussionsupporting

confidence: 70%

Effects of divalent cations and of catecholamines on the late response of the superior cervical ganglion.

Chen¹

1975

The Journal of Physiology

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“…Following oral or inhalation exposure, cadmium enters the systemic circulation and approximately 50% of absorbed cadmium is first captured by the liver (Perry et al, 1970;Zalups and Ahmad, 2003). Depending on the dose and time exposure, cadmium induces hepatocyte swelling, steatosis, focal and massive necrosis and ultrastructural changes (Dudley et al, 1982(Dudley et al, , 1984Habeebu et al, 1998;Tzirogiannis et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Cadmium disorganises the scaffolding of gap and tight junction proteins in the hepatic cell line WIF B9

Boucherie

Decaëns

Verbavatz

et al. 2013

Biology of the Cell

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“…After subcutaneous or intravenous administration cadmium is concentrated predominantly in the kidneys, liver (Berlin and Ullberg, 1963;Lucis et al, 1969), pancreas, spleen, and intestine (Decker and Byerrum, 1956), and even in the endocrine glands (Berlin and Ullberg, 1963). During the 10 minutes after intravenous administration the content of cadmium in liver quickly increases whereas the content of the kidneys remains relatively constant in the same period (Perry et al, 1970). Berlin and Ullberg (1963) studied the body distribution of cadmium in mice at various times after a single intravenous dose of 109CdC12, using the autoradiography method with sagittal whole-body sections.…”

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Excretion of cadmium through bile and intestinal wall in rats

Cikrt

Tichý

1974

Occupational and Environmental Medicine

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of cadmium through bile and intestinal wall in rats. The excretion of Cd2+ through the bile and intestinal wall after intravenous administration of CdC12 in non-toxic doses (67, 90, and 120 ,ug of Cd2+ per rat) was studied in rats. The cumulative biliary excretion reached 24 hours after administration of the 67 jug dose was 0 83 %, after 90 jig 1-18 %, and after the 120 ,tg dose 5-68 % of the amount given. The highest excretion rate of Cd2+ was detected between 15 and 30 minutes after administration. There was no difference in the excretion through intestinal wall between the 67 and 120 ,ug doses of Cd2+ per rat. The mean amount of cadmium found in the contents of the entire gastrointestinal tract and faeces was 5-5 % of the administered dose. Using polyacrylamide gel disc electrophoresis it was found that Cd2+ is bound with at least two different components of the rat bile.

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Hypertension and tissue metal levels following intravenous cadmium, mercury, and zinc

Cited by 42 publications

References 0 publications

Effects of divalent cations and of catecholamines on the late response of the superior cervical ganglion.

Effects of divalent cations and of catecholamines on the late response of the superior cervical ganglion.

Cadmium disorganises the scaffolding of gap and tight junction proteins in the hepatic cell line WIF B9

Excretion of cadmium through bile and intestinal wall in rats

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