Hypertension and Triglyceride Catabolism: Implications for the Hemodynamic Model of the Metabolic Syndrome

Brook, Robert D.; Glazewski, Lynn; Rajagopalan, Sanjay; Bard, Robert L.

doi:10.1080/07315724.2003.10719306

Cited by 6 publications

(4 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Image analyses were performed using semi-automated software (Medical Imaging Applications, Inc). Arterial compliance was measured by radial artery tonometry using the CVProfilor as described before (Hypertension Diagnostics, Inc) 18 .…”

Section: Methodsmentioning

confidence: 99%

Insights Into the Mechanisms and Mediators of the Effects of Air Pollution Exposure on Blood Pressure and Vascular Function in Healthy Humans

et al. 2009

Self Cite

View full text Add to dashboard Cite

Fine particulate matter air pollution plus ozone impairs vascular function and raises diastolic blood pressure. We aimed to determine the mechanism and air pollutant responsible. The effects of pollution on heart rate variability, blood pressure, biomarkers, and brachial flow-mediated dilatation were determined in 2 randomized, double-blind, cross-over studies. In Ann Arbor, 50 subjects were exposed to fine particles (150 μg/m3) + ozone (120 ppb) for 2 hours on 3 occasions with pretreatments of an endothelin antagonist (Bosentan 250 mg), anti-oxidant (Vitamin C 2 g), or placebo. In Toronto, 31 subjects were exposed to 4 different conditions (particles + ozone, particles, ozone, and filtered air). In Toronto, diastolic blood pressure significantly increased (2.9 and 3.6 mm Hg) only during particle-containing exposures in association with particulate matter concentration and reductions in heart rate variability. Flow-mediated dilatation significantly decreased (2.0 and 2.9%) only 24 hours after particle-containing exposures in association with particulate matter concentration and increases in blood tumor necrosis factor-alpha. In Ann Arbor, diastolic blood pressure significantly similarly increased during all exposures (2.5 - 4.0 mm Hg), a response not mitigated by pretreatments. Flow-mediated dilatation remained unaltered. Particulate matter, not ozone, was responsible for increasing diastolic blood pressure during air pollution inhalation most plausibly by instigating acute autonomic imbalance. Only particles from urban Toronto additionally impaired endothelial function likely via slower proinflammatory pathways. Our findings demonstrate credible mechanisms whereby fine particulate matter could trigger acute cardiovascular events and that aspects of exposure location may be an important determinant of the health consequences.

show abstract

Section: Methodsmentioning

confidence: 99%

Insights Into the Mechanisms and Mediators of the Effects of Air Pollution Exposure on Blood Pressure and Vascular Function in Healthy Humans

et al. 2009

Self Cite

View full text Add to dashboard Cite

show abstract

“…Natural oil occurring lipophilic antioxidants (e.g. vitamin E, beta-carotene, lavonoids, monoterpene, terpenoids) inhibited the oxidative modi ication of low-density lipoproteins [73][74][75][76][77][78][79][80]. Studies showed that they could possibly prevent atherogenesis and coronary heart diseases.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Therapeutic application of herbal essential oil and its bioactive compounds as complementary and alternative medicine in cardiovascular-associated diseases

Lajis¹,

Ismail²

2020

Insights Depress Anxiety

View full text Add to dashboard Cite

show abstract

“…The exact mechanism whereby the metabolic syndrome influences vascular outcome is unknown. It is thought that the constituents of metabolic syndrome may perpetuate increased vascular risk through mechanisms including insulin resistance, [43][44][45][46] hypercoaguability, 47 endothelial dysfunction, 48 and inflammation. 31 Biomarkers of vascular risk including C-reactive protein (CRP) are elevated in children, adolescents, and adults with the metabolic syndrome.…”

Section: Possible Mechanisms Underlying the Metabolic Syndromementioning

confidence: 99%

Current Understanding of Multiple Risk Factors as the Metabolic Syndrome: Distillation or Deconstruction

Boden‐Albala¹

2006

Semin Neurol

View full text Add to dashboard Cite

The "metabolic syndrome" is a new term that defines the clustering of vascular risk factors, such as hyperlipidemia, obesity, elevated blood pressure, and elevated blood glucose. Controversy exists regarding the use of the term, which raises the question of whether the unique grouping of vascular risk factors adds more clinical risk then the additive effect of multiple risk factors viewed as separate but important entities. Whatever the answer, the metabolic syndrome constitutes a major public health problem with over 47 million persons in the United States meeting criteria for the metabolic syndrome. Although studies have demonstrated that the metabolic syndrome is a risk factor for overall mortality as well as cardiovascular events, the relationship between the metabolic syndrome and ischemic stroke has not been well characterized. Two large cross-sectional studies report an association between metabolic syndrome and increased risk of a history of stroke. One large multiethnic prospective study found the metabolic syndrome to be significantly associated with an increased risk of ischemic stroke after adjustment for sociodemographics and other cardiovascular risk factors. This study estimated that the metabolic syndrome may account for 19% of ischemic strokes including 30% of stroke in women and over 40% of stroke in Hispanics. Despite debate about the utility of its definition, there is evidence to suggest that the metabolic syndrome is an important risk factor for ischemic stroke, with differential effects by gender and race-ethnicity. Further, the metabolic syndrome has important clinical and public health implications by helping to easily identify individuals at greatest risk of vascular events.

show abstract

Hypertension and Triglyceride Catabolism: Implications for the Hemodynamic Model of the Metabolic Syndrome

Cited by 6 publications

References 21 publications

Insights Into the Mechanisms and Mediators of the Effects of Air Pollution Exposure on Blood Pressure and Vascular Function in Healthy Humans

Insights Into the Mechanisms and Mediators of the Effects of Air Pollution Exposure on Blood Pressure and Vascular Function in Healthy Humans

Therapeutic application of herbal essential oil and its bioactive compounds as complementary and alternative medicine in cardiovascular-associated diseases

Current Understanding of Multiple Risk Factors as the Metabolic Syndrome: Distillation or Deconstruction

Contact Info

Product

Resources

About