Hypertension in connective tissue disease

Luo, Qiang; Zhang, Yiwen; Yang, Xiaoqian; Li, Qin; Han, Wei

doi:10.1038/s41371-022-00696-8

Cited by 4 publications

(2 citation statements)

References 82 publications

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“…Patients with rheumatic and musculoskeletal diseases (RMDs) such as rheumatoid arthritis (RA), systemic lupus erythematous (SLE), osteoarthritis (OA), gout and Sjogren's syndrome are at an increased risk of developing HTN, with chronic inflammation as the main driver [4][5][6]. Chronic inflammation causes damage to the blood vessels and contributes to salt retention in the body through the inflammatory cytokines such as interleukin-6 and tumor necrosis factor-alpha stimulating the renin-angiotensin-aldosterone system [7].…”

Section: Introductionmentioning

confidence: 99%

High blood pressure prevalence, awareness, treatment, and blood pressure control among Ugandans with rheumatic and musculoskeletal disorders

Kibone,

Bongomin,

Okot

et al. 2023

PLoS ONE

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Background Rheumatic and musculoskeletal disorders (RMDs) are associated with cardiovascular diseases (CVDs), with hypertension being the most common. We aimed to determine the prevalence of high blood pressure (HBP), awareness, treatment, and blood pressure control among patients with RMDs seen in a Rheumatology clinic in Uganda. Methods We conducted a cross-sectional study at the Rheumatology Clinic of Mulago National Referral Hospital (MNRH), Kampala, Uganda. Socio-demographic, clinical characteristics and anthropometric data were collected. Multivariable logistic regression was performed using STATA 16 to determine factors associated with HBP in patients with RMDs. Results A total of 100 participants were enrolled. Of these, majority were female (84%, n = 84) with mean age of 52.1 (standard deviation: 13.8) years and median body mass index of 28 kg/m2 (interquartile range (IQR): 24.8 kg/m2–32.9 kg/m2). The prevalence of HBP was 61% (n = 61, 95% CI: 51.5–70.5), with the majority (77%, n = 47, 95% CI: 66.5–87.6) being aware they had HTN. The prevalence of HTN was 47% (n = 47, 37.2–56.8), and none had it under control. Factors independently associated with HBP were age 46-55years (adjusted prevalence ratio (aPR): 2.5, 95% confidence interval (CI): 1.06–5.95), 56–65 years (aPR: 2.6, 95% CI: 1.09–6.15), >65 years (aPR: 2.5, 95% CI: 1.02–6.00), obesity (aPR: 3.7, 95% CI: 1.79–7.52), overweight (aPR: 2.7, 95% CI: 1.29–5.77). Conclusion There was a high burden of HBP among people with RMDs in Uganda with poor blood pressure control, associated with high BMI and increasing age. There is a need for further assessment of the RMD specific drivers of HBP and meticulous follow up of patients with RMDs.

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Section: Introductionmentioning

confidence: 99%

High blood pressure prevalence, awareness, treatment, and blood pressure control among Ugandans with rheumatic and musculoskeletal disorders

Kibone,

Bongomin,

Okot

et al. 2023

PLoS ONE

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“…Inflammation is closely related to the occurrence and development of hypertension [ 5 – 7 ]. However, the mechanism underlying inflammation-induced hypertension is unclear.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil extracellular traps accelerate vascular smooth muscle cell proliferation via Akt/CDKN1b/TK1 accompanying with the occurrence of hypertension

Fang

Li²,

Yan³

et al. 2022

Journal of Hypertension

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Objective: Neutrophil extracellular traps (NETs) can trigger pathological changes in vascular cells or vessel wall components, which are vascular pathological changes of hypertension. Therefore, we hypothesized that NETs would be associated with the occurrence of hypertension. Methods: To evaluate the relationship between NETs and hypertension, we evaluated both the NETs formation in spontaneously hypertensive rats (SHRs) and the blood pressure of mice injected phorbol-12-myristate-13-acetate (PMA) via the tail vein to induce NETs formation in arterial wall. Meanwhile, proliferation and cell cycle of vascular smooth muscle cells (VSMCs), which were co-cultured with NETs were assessed. In addition, the role of exosomes from VSMCs co-cultured with NETs on proliferation signaling delivery was assessed. Results: Formation of NETs increased in the arteries of SHR. PMA resulted in up-regulation expression of citrullinated Histone H3 (cit Histone H3, a NETs marker) in the arteries of mice accompanied with increasing of blood pressure. NET treatment significantly increased VSMCs count and accelerated G1/S transition in vitro . Cyclin-dependent kinase inhibitor 1b (CDKN1b) was down-regulated and Thymidine kinase 1 (TK1) was up-regulated in VSMCs. Exosomes from VSMCs co-cultured with NETs significantly accelerated the proliferation of VSMCs. TK1 was up-regulated in the exosomes from VSMCs co-cultured with NETs and in both the arterial wall and serum of mice with PMA. Conclusion: NETs promote VSMCs proliferation via Akt/CDKN1b/TK1 and is related to hypertension development. Exosomes from VSMCs co-cultured with NETs participate in transferring the proliferation signal. These results support the role of NETs in the development of hypertension.

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Genetic analysis uncovers potential mechanisms linking juvenile ldiopathic arthritisto breast cancer: A Bioinformatic Pilot study

Jiang,

Yin,

Luo

et al. 2025

Cancer Genetics

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Hypertension in connective tissue disease

Cited by 4 publications

References 82 publications

High blood pressure prevalence, awareness, treatment, and blood pressure control among Ugandans with rheumatic and musculoskeletal disorders

High blood pressure prevalence, awareness, treatment, and blood pressure control among Ugandans with rheumatic and musculoskeletal disorders

Neutrophil extracellular traps accelerate vascular smooth muscle cell proliferation via Akt/CDKN1b/TK1 accompanying with the occurrence of hypertension

Genetic analysis uncovers potential mechanisms linking juvenile ldiopathic arthritisto breast cancer: A Bioinformatic Pilot study

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