Hypertension in Kidney Transplant Recipients

Cheigh, Jhoong S.

doi:10.1007/978-94-009-4271-4_6

Cited by 5 publications

(2 citation statements)

References 85 publications

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“…Post-transplantation hypertension is a serious clinical problem, since it is associated with a decrease in allograft survival [7,8,9] and is the most-important risk factor for cardiovascular morbidity and mortality in transplant patients [10]. Hypertension following renal transplantation appears to be more common in children than in adults [11].…”

Section: Introductionmentioning

confidence: 99%

A randomized prospective crossover trial of amlodipine in pediatric hypertension

Rogan

Lyszkiewicz

Blowey

et al. 2000

Pediatric Nephrology

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Amlodipine has potential advantages in children since it can be dissolved into a liquid preparation and has a long elimination half-life, allowing for once-daily administration. The objective of this study was to compare the efficacy and compliance of amlodipine with that of standard long-acting calcium channel blockers (felodipine or nifedipine) in hypertensive children. A randomized, prospective, crossover study of 11 hypertensive children (9-17 years of age, 10 renal transplant patients) was performed with electronic monitoring of compliance. Each treatment arm was 30 days. No significant differences were observed in mean systolic (SBP) and diastolic blood pressures (DBP) between amlodipine and the other calcium channel blockers. Using 24-h blood pressure monitoring there were no significant differences over each drug treatment period in both mean day-time and night-time SBP and DBP. Patient compliance was similar in both the amlodipine and the nifedipine/felodipine treatment periods. These data suggest that amlodipine is as effective in pediatric nephrology patients as nifedipine and felodipine. Amlodipine may be optimally suited for treatment of young children because at present it is the only calcium channel blocker which can be administered once daily as a liquid preparation.

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Section: Introductionmentioning

confidence: 99%

A randomized prospective crossover trial of amlodipine in pediatric hypertension

Rogan

Lyszkiewicz

Blowey

et al. 2000

Pediatric Nephrology

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“…It is also known from the literature that vasoconstrictors, such as angiotensin-II, endothelin-1 and thromboxane-A2, may stimulate to proliferation of smooth muscle cells, either directly or acting in synergy with growth factors (Figure 1). It has been claimed that pretransplant and posttransplant hypertension is a major risk factor for chronic renal transplant dysfunction [28][29][30][31][32][33] since patients with deteriorating graft function had a higher level of treatment with antihypertensive drugs. 29 Hypertension was also recently suggested to be an independent risk factor for chronic graft failure, 34 based upon a multivariate analysis of posttransplant blood pressure and long-term kidney graft outcome.…”

Section: Hypertension and Accelerated Atherosclerosismentioning

confidence: 99%

Accelerated atherosclerosis in the transplant recipient: role of hypertension

et al. 1998

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An accelerated atherosclerosis may occur in the native arteries of a transplant recipient as well as in arteries of transplanted kidneys or hearts. The dominating cause of patient mortality are cardiovascular diseases, where ischaemic heart disease is predominant. The accelerated form of arteriosclerosis which takes place in transplanted kidneys and hearts, has a complex pathogenesis, which includes both immunological and non-

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Posttransplant Hypertension

Laskow

Curtis

1998

Suki and Massry’s THERAPY OF RENAL DISEASES AND RELATED DISORDERS

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Hypertension in Kidney Transplant Recipients

Cited by 5 publications

References 85 publications

A randomized prospective crossover trial of amlodipine in pediatric hypertension

A randomized prospective crossover trial of amlodipine in pediatric hypertension

Accelerated atherosclerosis in the transplant recipient: role of hypertension

Posttransplant Hypertension

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