2008
DOI: 10.1016/j.ecl.2008.06.002
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Hypertension in Obesity

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Cited by 42 publications
(37 citation statements)
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References 86 publications
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“…Obesity is firmly established as a cause of hypertension, although additional mechanisms besides hyperinsulinemia have been proposed as mechanisms (35,42,56,63). Therefore, it is not surprising that a sodium-retaining action of insulin has continued to be advanced as a contributing factor for sodium retention and hypertension in obesity or metabolic syndrome (53,77,80).…”
Section: Conclusion 1: Insulin Is a Sodium Retainermentioning
confidence: 99%
“…Obesity is firmly established as a cause of hypertension, although additional mechanisms besides hyperinsulinemia have been proposed as mechanisms (35,42,56,63). Therefore, it is not surprising that a sodium-retaining action of insulin has continued to be advanced as a contributing factor for sodium retention and hypertension in obesity or metabolic syndrome (53,77,80).…”
Section: Conclusion 1: Insulin Is a Sodium Retainermentioning
confidence: 99%
“…Obese patients are more likely to have hypertension, due to a multifaceted pathophysiology involving insulin resistance and renal derangement among other factors (40). All patients are at risk for acute elevations in blood pressure during a procedure because of pain-induced sympathetic stimulation and recent discontinuation of oral antihypertensive medications.…”
Section: Hypertension Managementmentioning
confidence: 99%
“…CTRP1 stimulates aldosterone production through the induction of CYP11B2 gene expression [1]. Obesity and metabolic syndrome are frequently associated with elevated levels of aldosterone [7] and it is well known that obesity is the leading cause of hypertension [8,9]. Elevated aldosterone levels and expanded extracellular volume are key components of obesity-induced renal disease via aldosterone's non-epithelial effects on the kidney [7].…”
Section: Introductionmentioning
confidence: 99%