Hypertension in Pregnancy

Gbala, Michael Olumide; Adegoke, Adedokun Isaac

doi:10.1007/978-3-030-75385-6_26

Cited by 2 publications

(1 citation statement)

References 47 publications

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“…Preeclampsia (PE), a hypertensive pregnancy disorder, is one of the three leading causes of maternal mortality worldwide [ 8 ]. Oxidative stress-mediated endothelial damage may be the ultimate common mechanism causing tissue damage and is crucial in the pathophysiology of PE [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Association of catechol-o-methyltransferase gene polymorphism with preeclampsia and biomarkers of oxidative stress: Study protocol for a prospective case-control study in Pakistan

Yousuf,

Fatima,

Rehman

et al. 2024

PLoS ONE

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Background Preeclampsia is one of the three leading causes of worldwide maternal mortality. Oxidative stress-mediated endothelial damage is expected to be an ultimate common mechanism in the pathophysiology of preeclampsia. The role of bioamines is also well-established in the induction of preeclampsia. This project is aimed to understand the factors which may affect the induction, progression, and aggravation of preeclampsia and oxidative stress during pregnancy. This study will explore the methylation pattern of the Catechol-O-methyltransferase gene to determine its role in the pathogenesis of preeclampsia, association of Val158Met polymorphism with a wide range of oxidative stress biomarkers, major antioxidants vitamins, and blood pressure regulating amines in preeclamptic Pakistani women. Methods and analysis In this prospective case-control study, 85 preeclamptic and 85 normotensive pregnant women will be recruited in their third trimesters. DNA will be extracted from peripheral blood and Val158Met polymorphism in the Catechol-O-methyltransferase gene will be examined on PCR amplified product digested with Hin1II (NlaIII) restriction enzyme, further validated by Sanger sequencing. Methylation-sensitive PCR will also be performed. Oxidative stress biomarkers, antioxidant vitamins, bioamines, and catechol-O-methyltransferase levels will be measured by ELISA. The data will be used to correlate maternal and fetal outcomes in both groups. Discussion This study will help to identify and understand the multifactorial path and cause-effect relationship of gene polymorphism, oxidative stress biomarkers, major antioxidants vitamins, and blood pressure regulating amines in the pathogenesis and aggravation of preeclampsia in the Pakistani population. The outcome of this project will be particularly helpful in reducing the incidence of preeclampsia and further improving its management.

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Section: Introductionmentioning

confidence: 99%

Association of catechol-o-methyltransferase gene polymorphism with preeclampsia and biomarkers of oxidative stress: Study protocol for a prospective case-control study in Pakistan

Yousuf,

Fatima,

Rehman

et al. 2024

PLoS ONE

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Сучасні Погляди На Молекулярні Та Судинні Механізми Розвитку Прееклампсії

Shumilina

Slyvka²

2021

USMYJ

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the article summarizes the arguments and counterarguments in the scientific discussion on the mechanisms of preeclampsia. The main purpose of this study is to summarize information about the molecular and vascular mechanisms of preeclampsia. Thanks to a detailed study of literature sources, their systematization and approaches to solving the problem, it was found that genetic and environmental factors cause placental maladaptation, which leads to defective placentation, apoptosis of invasive cytotrophoblasts, inadequate expansive remodeling of spiral arteries. The relevance of the study of this pathology is that it largely determines the perinatal and maternal morbidity. However, today there is no clear idea about the features of the molecular and vascular mechanisms of preeclampsia, which leads to inconsistencies in the treatment of such pregnant women, which averts timely, adequate treatment and prevention. The bibliosemantic method and the content analysis of the literature concerning questions of new researches on features of mechanisms of development of preeclampsia were used. The article presents the results of studies that have shown that placental ischemia promotes the release of bioactive factors into the maternal circulation, causing an imbalance between antiangiogenic soluble tyrosine kinase-1, soluble endoglin and proangiogenic vascular endothelial growth factor stimulates the release of proinflammatory cytokines, hypoxia-inducing factor, reactive oxygen species and agonistic autoantibodies to type 1 angiotensin receptors. These circulating factors target the vascular endothelium, causing generalized endotheliosis in the systemic, renal, cerebral, and hepatic vessels, and lead to a decrease in vascular dilators such as nitric oxide, prostacyclin, hyperpolarization factor, and increased vasoconstrictors such as endothelin-1 and thromboxane A2. Bioactive factors also affect vascular smooth muscle and enhance vascular contraction mechanisms, including cytosolic , protein kinase C, and Rho-kinase. The study empirically confirms and theoretically proves that further understanding of the interaction between bioactive factors, vascular mechanisms and molecular targets should help to develop more effective measures for early detection and prevention of preeclampsia. The results of the study will be useful for primary care physicians, gynecologists, cardiologists, therapists.

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Hypertension in Pregnancy

Cited by 2 publications

References 47 publications

Association of catechol-o-methyltransferase gene polymorphism with preeclampsia and biomarkers of oxidative stress: Study protocol for a prospective case-control study in Pakistan

Association of catechol-o-methyltransferase gene polymorphism with preeclampsia and biomarkers of oxidative stress: Study protocol for a prospective case-control study in Pakistan

Сучасні Погляди На Молекулярні Та Судинні Механізми Розвитку Прееклампсії

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