Hypertension in psoriasis patients: based on office and ambulatory blood pressure measurement

Abstract

Objective Psoriasis is a chronic inflammatory disorder, which is associated with high risk of metabolic comorbidities. Hypertension (HTN) is among the most common and serious associations. In this study, we aimed to evaluate HTN in psoriatic patients through office and ambulatory blood pressure monitoring (ABPM). Materials and methods Forty-nine patients with confirmed diagnosis of psoriasis were enrolled in the study. Office measurement of blood pressure was performed and then holter monitoring was used for 24-h ABPM. Results Thirty-six patients (73.4%) had HTN including 13 females (36.1%) and 23 males (63.9%) (P = 0.011). Twelve patients (33.3%) had masked HTN (six females and six males). Office, 24-h, morning, daytime, and nocturnal HTN were present in 49%, 40.8%, 34.7%, 36.7%, and 63.3% of our patients, respectively. The only factor significantly related to morning/daytime/24 h HTN was age, which hypertensive patients had higher age. About 22.4% of patients had metabolic syndrome, which was significantly associated with FBS, weight, waist circumference, and BMI. Conclusion Psoriasis is associated with a high rate of HTN. Masked HTN constitutes nearly one-third of hypertensive patients. ABPM increases the accuracy of HTN detection in psoriatic patients.

Psoriasis in the pediatric population: comorbidities with psoriasis

“…Hypertension may be a risk factor for the development of psoriasis, mainly due to patients' use of blood pressure-lowering drugs such as β-blockers [85]. Abnormal activation of inflammatory cells with overexpression of pro-inflammatory cytokines in psoriasis set in motion an immune cascade, leading to vascular endothelial damage, collagen deposition in arteries, vascular stiffening, and the appearance of elevated blood pressure [86][87][88][89][90][91][92]. Children with psoriasis also have an increased incidence of hypertension.…”