Hypertension in Takayasu Disease: PP.15.72

Hmida, M. Ben; Maazoun, F.; Marzouk, S.; Frigui, M.; Bouattour, F; Chaabouni, Y.; Salah, R. Ben; Kacem, Hatem Hadj; Kaddour, N.; Bahloul, Z.

doi:10.1097/01.hjh.0000378998.52257.6d

Cited by 4 publications

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“…Through the diagram, 69.2% of patients could be classified into the right prognosis group. AR: aortic regurgitation and immunosuppressive drugs might contribute to the genesis of hypertension in TAK [29]. Former studies have also found that dysfunctional baroreceptors are possible mechanisms involved in causing hypertension [30].…”

Section: Discussionmentioning

confidence: 99%

“…In Cluster 2, hypertension might be caused by the involvement of the ascending aorta, thoracic aorta, aortic arch, and its branches instead of the renal and abdominal aorta. Hamida et al reported that lesions of supraaortic trunks, carotid lesions, and immunosuppressive drugs might contribute to the genesis of hypertension in TAK [ 29 ]. Former studies have also found that dysfunctional baroreceptors are possible mechanisms involved in causing hypertension [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

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Clinical characteristics, imaging phenotypes and events free survival in Takayasu arteritis patients with hypertension

Sun

Wang

et al. 2021

Arthritis Res Ther

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Background Hypertension occurred in 30–80% of Takayasu arteritis (TAK) patients around the world and the occurrence of hypertension might worsen the disease prognosis. This study aimed to investigate the clinical characteristics and imaging phenotypes, as well as their associations with events free survival (EFS) in Chinese TAK patients with hypertension. Methods This current research was based on a prospectively ongoing observational cohort-the East China Takayasu Arteritis (ECTA) cohort, centered in Zhongshan Hospital, Fudan University. Totally, 204 TAK patients with hypertension were enrolled between January 2013 and December 2019. Clinical characteristics and imaging phenotypes of each case were evaluated and their associations with the EFS by the end of August 30, 2020, were analyzed. Results Severe hypertension accounted for 46.1% of the entire population. Three specific imaging phenotypes were identified: Cluster 1: involvement of the abdominal aorta and/or renal artery (27.5%); Cluster 2: involvement of the ascending aorta, thoracic aorta, the aortic arch, and/or its branches (18.6%); and Cluster 3: combined involvement of Cluster 1 and 2 (53.9%). Clinical characteristics, especially hypertensive severity, differed greatly among the three imaging clusters. In all, 187 patients were followed up for a median of 46 (9–102) months; 72 events were observed in 60 patients (1–3 per person). The overall blood pressure control rate was 50.8%, and the EFS was 67.9% by the end of the follow-up. Multivariate Cox regression indicated that controlled blood pressure (HR = 2.13, 95% CI 1.32–3.74), Cluster 1 (HR = 0.69, 95% CI 0.48–0.92) and Cluster 3 (HR = 0.72, 95% CI 0.43–0.94) imaging phenotype was associated with the EFS. Kaplan–Meier curves showed that patients with controlled blood pressure showed better EFS (p = 0.043). Furthermore, using cases with Cluster 1 imaging phenotype and controlled blood pressure as reference, better EFS was observed in patients with Cluster 2 phenotype and controlled blood pressure (HR = 2.21, 95%CI 1.47–4.32), while the case with Cluster 1 phenotype plus uncontrolled blood pressure (HR = 0.64, 95%CI 0.52–0.89) and those with Cluster 3 phenotype and uncontrolled blood pressure (HR = 0.83, 95%CI 0.76–0.92) suffered worse EFS. Conclusion Blood pressure control status and imaging phenotypes showed significant effects on the EFS for TAK patients with hypertension.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%