1992
DOI: 10.1159/000186876
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Hypertension in Unilateral Atrophic Kidney Secondary to Ureteropelvic Junction Obstruction

Abstract: A patient with atrophic unilateral hydronephrosis due to ureteropelvic junction obstruction associated with hypertension was successfully treated by nephrectomy. Preoperatively, plasma renin activity was elevated in both the peripheral vein and affected renal vein. Renin concentration in the resected kidney was high, and immunohistochemical localization of renin was observed along the afferent arterioles of the juxtaglomerular apparatus and in arterioles at some distance from the glomeruli.

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Cited by 13 publications
(14 citation statements)
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“…Secondary hypertension occurring as a consequence of hydronephrosis has been described in a small number of animal models 1 and clinical reports. [2][3][4][5] Interestingly, based upon the limited number of cases, unilateral hydronephrosis appears to be sufficient to cause hypertension. 2,4,5 The presence of a normal contralateral kidney may not be adequate to mitigate the effect of the hydronephrosis.…”
Section: Discussionmentioning
confidence: 99%
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“…Secondary hypertension occurring as a consequence of hydronephrosis has been described in a small number of animal models 1 and clinical reports. [2][3][4][5] Interestingly, based upon the limited number of cases, unilateral hydronephrosis appears to be sufficient to cause hypertension. 2,4,5 The presence of a normal contralateral kidney may not be adequate to mitigate the effect of the hydronephrosis.…”
Section: Discussionmentioning
confidence: 99%
“…[2][3][4][5] Interestingly, based upon the limited number of cases, unilateral hydronephrosis appears to be sufficient to cause hypertension. 2,4,5 The presence of a normal contralateral kidney may not be adequate to mitigate the effect of the hydronephrosis. Some authors describe resolution of hypertension following removal of the affected kidney, 5 while others show that relief of obstruction may also lead to normalisation of blood pressure.…”
Section: Discussionmentioning
confidence: 99%
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