Hypertension increases the contractions to sumatriptan in the human internal mammary artery

Yıldız, Oğuzhan; Çïçek, Sertaç; Ay, İlknur; Demirkılıç, Ufuk; Tuncer, Meral

doi:10.1016/0003-4975(96)00674-1

Cited by 19 publications

(16 citation statements)

References 19 publications

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“…In humans and in animals, 5-HT predominantly causes direct arterial constriction, and the list of references here are just a few that report the effects of 5-HT in the isolated artery; more are included in the legend to Fig. 2: McGregor and Smirk, 1970;Docherty, 1988;Rosón et al, 1990;Vanhoutte, 1991;van Zwieten et al, 1992;Webb et al, 1992;Nishimura and Suzuki, 1995;Nishimura, 1996;Yildiz et al, 1996Yildiz et al, , 1998Boston and Hodgson, 1997;Watts, 1997Watts, , 2002Watts, , 2005Watts, , 2009HutriKähönen et al, 1999;Ramage, 2001;Janiak et al, 2002;Doggrell, 2003;Gul et al, 2003;Côté et al, 2004;Watts and Thompson, 2004;Villalón and Centurión, 2007;Ramage and Villalón, 2008;Nichols, 2009;and Nigmatullina et al, 2009. These studies have been performed in a variety of isolated blood vessels-basilar, superior mesenteric, aortic, femoral, mesenteric resistance, for example-such that constriction cannot be attributed to a single receptor type or size of vessel.…”

Section: -Hydroxytryptamine Synthesis and Handlingmentioning

confidence: 99%

Serotonin and Blood Pressure Regulation

et al. 2012

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Section: -Hydroxytryptamine Synthesis and Handlingmentioning

confidence: 99%

Serotonin and Blood Pressure Regulation

et al. 2012

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“…The contribution of 5-HT 1F receptors to sumatriptan-induced contractions in various vessels seems small or negligible (Ishida et al 1999;Nilsson et al 1999). 5-HT 1B receptors are expressed also in other human vessels such as the mesenteric (Kaumann et al 1993), coronary Connor et al 1989;Toda and Okamura 1990;Borton et al 1990;Kaumann et al 1994) and internal mammary (IMA) (Yildiz et al 1996a(Yildiz et al , 1996b arteries. Sumatriptan reportedly induces chest pain, myocardial ischaemia, coronary vasospasm and myocardial infarction (Hillis and MacIntyre 1993;Kelly 1995;O'Connor and Gladstone 1995;Mueller et al 1996).…”

mentioning

confidence: 98%

“…Serotonin acts on human mesenteric (Wallerstedt et al 1996;Nilsson et al 1997) and internal mammary arteries (Conti et al 1990;Yildiz et al 1996a) mainly through 5-HT 2A receptors. Contractions in response to the 5-HT 1B selective agonist sumatriptan are weak in these arteries (Conti et al 1990;Yildiz et al 1996b).…”

mentioning

confidence: 99%

Amplification of sumatriptan-induced contractions with phenylephrine, histamine and KCl in the isolated human mesenteric artery: in-vitro evidence for sumatriptan-induced mesenteric ischaemia

Gül

Yıldız

2002

Naunyn-Schmiedeberg's Archives of Pharmacology

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Sumatriptan, a 5-HT(1B/1D/1F) receptor agonist, is used to relieve migraine headache. Sumatriptan contracts some arteries either directly or after modest precontraction with non-serotonergic agonists. Sumatriptan can cause myocardial ischaemia and myocardial infarction. While previous in-vitro studies have shown that sumatriptan has no or only weak contractile activity in human omental arteries, recent clinical studies suggest that sumatriptan may induce mesenteric ischaemia. The aim of this study was to investigate the presence of contractile 5-HT(1B) receptors in the human mesenteric artery and to establish whether the weak sumatriptan-induced contractions are amplified by precontraction with various contractile substances. The study was performed in organ baths using endothelium-denuded isolated human mesenteric arteries. Sumatriptan induced concentration-dependent contractions in some mesenteric arteries [ E(max) 61+/-10% of the maximum contraction induced by 80 mM KCl, pD(2) (-log(10)EC(50)) 6.56+/-0.20, n=9]. In the other mesenteric arteries, sumatriptan induced only very weak ( E(max) <5%) or no contraction ( n=13). GR127935 (3 nM), a selective 5-HT(1B) receptor antagonist, antagonized sumatriptan-induced contractions insurmountably in sumatriptan-sensitive arteries. When the resting tension of the arterial rings was increased moderately by threshold concentrations (EC(10)-EC(20) of maximum contraction induced by 80 mM KCl) with the non-5-HT receptor agonists phenylephrine (10-100 nM), histamine (100 nM-1 microM) or the depolarizing agent KCl (4-10 mM), 5-HT(1B) receptor-mediated responses were amplified in sumatriptan-insensitive arteries (with phenylephrine E(max) 82+/-17%, pD(2) 6.64+/-0.20, n=7; with histamine E(max) 107+/-26%, pD(2) 6.16+/-0.14, n=6; with KCl E(max) 78+/-16%, pD(2) 6.45+/-0.15, n=7). These results show that sumatriptan induced concentration-dependent contractions in sumatriptan-sensitive mesenteric arteries and that 5-HT(1B) receptors were present and active in these vessels. However, in sumatriptan-insensitive arteries, precontraction is required for sumatriptan to induce concentration-dependent contractions. These findings suggest that sumatriptan may induce ischaemia in human mesenteric vasculature directly or in the presence of precontractile risk factors.

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“…Studies on human IMA have shown that 5-HT directly contracts IMA through 5-HT 1D and 5-HT 2 receptors [33,[108][109][110]. In IMA, 5-HT receptor mediated contractions are unmasked when endothelium is denuded [13,42].…”

Section: -Ht Receptor Antagonistsmentioning

confidence: 99%

“…In IMA, 5-HT receptor mediated contractions are unmasked when endothelium is denuded [13,42]. Additionally, studies have shown 5-HT may interact synergistically with other vasoconstrictor substances, such as TxA 2 released from platelets during thrombus formation, and 5-HT receptor mediated contractions may be unmasked or amplified [33,[108][109][110]. 5-HT 2A receptor antagonist ketanserin has antihypertensive properties and it's recently used to reduce the severity and frequency of the vasospasm in Raynaud's phenomenon [111].…”

Section: -Ht Receptor Antagonistsmentioning

confidence: 99%