Hypertension, metabolic syndrome, prediabetes, and diabetes associated with obstructive sleep apnea syndrome

Breuer, Heinz‐Peter

doi:10.1007/s11818-011-0503-3

Cited by 3 publications

(5 citation statements)

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“…The remaining 1,735 studies were further screened, and 32 were selected for full‐text review. In the full‐text assessment for final inclusion, seven studies were excluded because: (i) data could not be extracted ( n = 1) 15 ; (ii) the outcome was accessed only by self‐reports or questionnaires ( n = 2) 16 , 17 ; and (iii) different definition criteria ( n = 4) 18 , 19 , 20 , 21 . Finally, 25 studies with a total of 154,948 participants met our inclusion criteria (Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…The AHI was defined as the number of apneas and hypopneas per hour of sleep. Patients were classified as no (AHI <5), mild (AHI of 5-14.9), moderate (AHI of [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] or severe (AHI ≥30) OSA 9 . Therefore, we further analyzed the association of OSA with type 2 diabetes mellitus according to AHI severity.…”

Section: Osa Assessmentmentioning

confidence: 99%

“…Subgroup analyses were carried out to assess the relationships between OSA severity and the prevalence or incidence of diabetes mellitus. Eight studies divided OSA participants into mild (AHI of 5-14.9), moderate (AHI of [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] and severe (AHI ≥30) groups 23,26,[28][29][30]33,34,39 . Three were cohort studies 23,26,28 , and five were cross-sectional studies 29,30,33,34,39 ; a meta-analysis for each study type was carried out separately.…”

Section: Subgroup Analysesmentioning

confidence: 99%

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Obstructive sleep apnea, prediabetes and progression of type 2 diabetes: A systematic review and meta‐analysis

Tan

Miao

Zhang

2022

J of Diabetes Invest

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Aims/Introduction: Obstructive sleep apnea (OSA) is related to prediabetes and diabetes. Whether patients with OSA have a higher risk of prediabetes/diabetes remains unclear. We aimed to carry out a meta-analysis of published studies to evaluate the relationships between OSA and prediabetes and diabetes, and the impact of the severity of OSA on diabetes. Materials and Methods: The PubMed, EMBASE and Cochrane databases were searched from January 2011 to July 2021. The associations between OSA and impaired fasting glucose, impaired glucose tolerance, impaired glucose regulation and diabetes mellitus were analyzed. We estimated the pooled odds ratios using fixed or random effects models. We included 25 studies comprising a total of 154,948 patients with OSA and risk factors for prediabetes/diabetes (20 and 16, respectively) in the analysis. Results: OSA was associated with a higher risk of impaired fasting glucose, impaired glucose tolerance, impaired glucose regulation and diabetes mellitus in the cohort studies and cross-sectional studies. The pooled odds ratios were 2.34 (95% confidence interval [CI] 1.16-4.72), 1.58 (95% CI 1.15-2.15), 1.65 (95% CI 1.12-2.42), 2.15 (95% CI 1.68-2.75) and 3.62 (95% CI 2.75-4.75), respectively. Subgroup analyses were based on the proportions of men and women. The results showed that OSA was a risk factor, and there was no significant difference between the two groups. The risk of diabetes increased with the severity of OSA. Conclusions: The risk of developing prediabetes and diabetes was higher in patients with OSA.

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Section: Resultsmentioning

confidence: 99%

Section: Osa Assessmentmentioning

confidence: 99%

Section: Subgroup Analysesmentioning

confidence: 99%

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Obstructive sleep apnea, prediabetes and progression of type 2 diabetes: A systematic review and meta‐analysis

Tan

Miao

Zhang

2022

J of Diabetes Invest

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“…All of the included studies were reviewed by full text. Of the included studies, 15 were cross-sectional [ 18 , 26 – 33 , 35 – 37 , 40 , 42 , 43 ], five were case–control [ 17 , 34 , 38 , 39 , 41 ], and none were cohort studies. In total, 2456 patients with OSA and 1705 subjects with no OSA in cross-sectional studies, together with 1156 OSA patients and 404 controls in case–control studies, were included in the meta-analysis for the association of OSA with MS (Fig.…”

Section: Resultsmentioning

confidence: 99%

“… ATP III 187 79 % 40 48 % No 4.19 (2.05–8.56) None 6 H.-W.M. Breuer, 2011 [ 40 ] Hospital-based study, Germany. PSG; AHI ≥ 5 events/h.…”

Section: Resultsmentioning

confidence: 99%

The association between obstructive sleep apnea and metabolic syndrome: a systematic review and meta-analysis

et al. 2015

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BackgroundObstructive sleep apnea (OSA) is characterized by repeated episodes of obstruction of the upper airway. Numerous studies have indicated a relationship between OSA and metabolic syndrome (MS), but the results remain debatable. We aimed to perform a systematic review and meta-analysis to evaluate the association between OSA and MS.MethodsWe searched electronic databases (PubMed, EMBASE, and ISO Web of Knowledge) up to September 2014 with English-language restriction. Cross-sectional, case–control, and cohort studies in which the presence of OSA was assessed by objective measurements, the exposure of interest was OSA, and the outcome of interest was the presence (or incidence) of MS were included. The adjusted odds ratios (ORs) (or relative risk) and 95 % confidence intervals (CIs) were extracted and pooled. Sensitivity analyses were conducted, and heterogeneity and publication bias were assessed.ResultsOverall, 15 cross-sectional (2456 patients with OSA and 1705 subjects without OSA), five case–control (1156 OSA patients and 404 controls), and no cohort studies were included. The pooled ORs of MS in individuals with OSA for cross-sectional and case–control studies were 2.87 (95 % CI: 2.41–3.42) and 2.56 (95 % CI: 1.98–3.31), respectively. There was clinically unimportant (I2 = 20 %) and moderate (I2 = 35 %) between-study heterogeneity of the analysis. The pooled crude ORs of MS in individuals with mild and moderate-to-severe OSA was 2.39 (95 % CI: 1.65–3.46) and 3.45 (95 % CI: 2.33–5.12), respectively, and there was substantial heterogeneity in the meta-analyses (I2 = 53 % and I2 = 63 %, respectively). However, no evidence of publication bias was detected.ConclusionsOSA is shown to be associated with MS, although causality between these two factors has not been demonstrated yet. Future cohort and randomized controlled studies are needed.Electronic supplementary materialThe online version of this article (doi:10.1186/s12890-015-0102-3) contains supplementary material, which is available to authorized users.

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CPAP for Obstructive Sleep Apnea and the Metabolic Syndrome

2012

N Engl J Med

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Hypertension, metabolic syndrome, prediabetes, and diabetes associated with obstructive sleep apnea syndrome

Abstract: · Zusammenfassung Somnologie 2011 · 15:14-23

Cited by 3 publications

References 28 publications

Obstructive sleep apnea, prediabetes and progression of type 2 diabetes: A systematic review and meta‐analysis

Obstructive sleep apnea, prediabetes and progression of type 2 diabetes: A systematic review and meta‐analysis

The association between obstructive sleep apnea and metabolic syndrome: a systematic review and meta-analysis

CPAP for Obstructive Sleep Apnea and the Metabolic Syndrome

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