Hypertension, pre-eclampsia and eclampsia: Monitoring and outcome of pregnancy

Grujić, Ilija; Milasinović, L

doi:10.2298/mpns0612556g

Cited by 8 publications

(7 citation statements)

References 1 publication

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“…Hypertensive disorder of pregnancy is considered to be a major worldwide problem and presents an increased risk of both maternal and perinatal mortality and morbidity [26,27]. Preeclampsia, a multisystem disorder partly of unknown aetiology specific to pregnancy [28], has been implicated as one of the main predisposing factors for intrauterine foetal growth restriction and prematurity [29].…”

Section: Low Birth Weight and Preterm Birthmentioning

confidence: 99%

Maternal and obstetric risk factors for low birth weight and preterm birth in rural Gambia: a hospital-based study of 1579 deliveries

Jammeh¹,

Sundby²,

Vangen³

2011

OJOG

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Introduction: Low birth weight and prematurity are risk factors for perinatal morbidity and mortality, which is high in Sub Saharan African countries. We determined the frequency of and maternal and obstetric risk factors for low birth weight and preterm birth among hospital births in rural Gambia. Method: We performed a hospital-based retrospective analysis of deliveries from July to December 2008 in two rural hospitals. Maternity records were reviewed and abstracted of the mother's demographic and reproductive characteristics, obstetric complications and foetal outcome. The maternity records contain important information maternal health and complications during pregnancy and intrapartum period. The records also contain information about the newborn's vital status and birth weight. To determine the association between low birth weight (LBW), preterm birth (PTB) and maternal demographic characteristics and obstetric complications we calculated odds using logistic regression. Main outcome measure(s): Low birth weight (<2500 grams) and preterm birth (<37 weeks). Results: Our final sample included 1244 singleton live births with complete information about all variables. The rate of LBW and PTB were 10.5% and 10.9% respectively. Ninety-four percent of LBW infants were estimated to be preterm births. The mean birth weight was 3013 g (541 g standard deviation-SD), while the mean gestational age was 37 weeks. The pattern of risk factors was similar for LBW and PTB and both were strongly associated with antepartum haemorrhage and hypertensive pregnancy disorders. Additionally, primi parity was a risk factor for both PTB and LBW. Conclusion: The percentage of low birth weight and preterm birth in rural hospitals in The Gambia is high. The most significant risk factors were those that may be detected during the antepartum period. Thus, vigilant monitoring during pregnancy, early detection and management of obstetric complications coupled with provision of timely obstetric care interventions are crucial for reducing

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Section: Low Birth Weight and Preterm Birthmentioning

confidence: 99%

Maternal and obstetric risk factors for low birth weight and preterm birth in rural Gambia: a hospital-based study of 1579 deliveries

Jammeh¹,

Sundby²,

Vangen³

2011

OJOG

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“…Pregnancy induced hypertension is one of the major causes of maternal and fetal/neonatal morbidity and mortality. 10 In a study to determine risk factors, prevalence, epidemiological parameters and maternalperinatal outcome in pregnant women with hypertensive disorder, found that 24 cases of intrauterine fetal demise out of 255 cases and 10 fetuses died during intrapartum period. Perinatal mortality was found to be 144/1000 births.…”

Section: Discussionmentioning

confidence: 99%

A clinical observational study in cases of eclampsia

Kanani

Garala

2019

Int J Reprod Contracept Obstet Gynecol

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Background: Eclampsia is a life threatening condition and one of the leading causes of maternal deaths worldwide. It is also associated with complications like acute renal failure, DIC, postpartum hemorrhage, etc. and adverse fetal outcomes. Hence we aimed to study fetomaternal outcomes in cases of Eclampsia.Methods: A total of 75 cases of eclampsia out of 13524 deliveries were evaluated, from 1st January 2016 to 30th June 2017 at RZ Hospital, a government tertiary referral centre. Maternal outcomes were studied for its complications, effectiveness of magnesium sulphate treatment, fetal outcome and mode of delivery.Results: Incidence rate of eclampsia was 0.55%, 62.66% of all cases were primigravida, 76% of cases were in age group of 21-26 years, 84% cases were from lower socio economic status, maternal mortality occurred in 2 of 75 cases. 66.67% of patients were of term pregnancy (37 to 42 weeks). 71%(53) patients delivered vaginally out of which 9 deliveries were spontaneous and 44 deliveries were induced vaginal delivery. 22 patients required caesarean section.Conclusions: Early detection and prevention of pregnancy induced hypertension and pre-eclampsia and other associated risk factors for eclampsia might help to reduce the incidence of eclampsia. Maternal adverse outcomes in this study were magnesium toxicity, acute renal failure (ARF), disseminated intravascular coagulation (DIC) and post partum hemorrhage (PPH) while 92% patients had no complications.

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“…Pregnancy-induced hypertension, pre-eclampsia and eclampsia are parts of hypertensive syndrome which is a life-threatening condition both for the mother and fetus [14]. Pregnancy itself is a state of increased oxidative stress, and the increase of the oxidative damage is considered important for the development of pregnancy complications such as PEE.…”

Section: Discussionmentioning

confidence: 99%

Thiobarbituric acid reactive substances as marker of oxidative stress in pregnancies with pre-eclampsia

et al. 2011

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Pre-eclampsia is characterized by increased lipid peroxidation and diminished antioxidant capacity. The aim of the study was to establish concentration of thiobarbituric acid reactive substances as a marker of lipid peroxidation in normal pregnancies and in pregnancies complicated with pre-eclampsia, and to estimate the possibility of using thiobarbituric acid reactive substances as a screening method for development of pre-eclampsia. The study was conducted at the Department of Obstetrics and Gynaecology, Clinical Centre of Vojvodina. The study included 57 singleton pregnancies, gestation > or = 24 weeks, of which 29 were healthy pregnancies and 28 were with pre-eclampsia, defined as systolic arterial pressure of > or = 90 mmHg, diastolic of > or = 145 mmHg, and 24h proteinuria of > or = 300 mg. Thiobarbituric acid reactive substances concentrations evaluated by malondialdehyde equivalent standards (OxiSelect TBARS Assay Kit (malondialdehyde Quantitation), Cell Biolabs' OxiSelect) showed that oxidative stress was more evident in the group with pre-eclampsia, though not statistically significant (p = 0.107). There was no correlation ofthiobarbituric acid reactive substance levels with gestation in either group. The differences between the level of thiobarbituric acid reactive substance concentrations in pre-eclampsia and healthy pregnancies indicate the possibility of using thiobarbituric acid reactive substances as a screening tool for the development of pre-eclampsia. Further studies with larger numbers of patients are needed in order to come to final conclusions.

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Hypertension, pre-eclampsia and eclampsia: Monitoring and outcome of pregnancy

Cited by 8 publications

References 1 publication

Maternal and obstetric risk factors for low birth weight and preterm birth in rural Gambia: a hospital-based study of 1579 deliveries

Maternal and obstetric risk factors for low birth weight and preterm birth in rural Gambia: a hospital-based study of 1579 deliveries

A clinical observational study in cases of eclampsia

Thiobarbituric acid reactive substances as marker of oxidative stress in pregnancies with pre-eclampsia

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