Hypertension regulating angiotensin peptides in the pathobiology of cardiovascular disease

Hussain, Misbah; Awan, Fazli Rabbi

doi:10.1080/10641963.2017.1377218

Cited by 48 publications

(31 citation statements)

References 83 publications

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“…In the same way, Ang II is a hormone involved in the pathophysiology of hypertension and atherosclerosis, which also exerts its effects through PKC [31,32]. In fact, Ang II is an activator of NOX5 in human microvascular endothelial cells [24].…”

Section: Discussionmentioning

confidence: 99%

Induction of Cyclooxygenase-2 by Overexpression of the Human NADPH Oxidase 5 (NOX5) Gene in Aortic Endothelial Cells

Marqués

Cortés

Pejenaute

et al. 2020

Cells

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Oxidative stress is a main molecular mechanism that underlies cardiovascular diseases. A close relationship between reactive oxygen species (ROS) derived from NADPH oxidase (NOX) activity and the prostaglandin (PG) biosynthesis pathway has been described. However, little information is available about the interaction between NOX5 homolog-derived ROS and the PG pathway in the cardiovascular context. Our main goal was to characterize NOX5-derived ROS effects in PG homeostasis and their potential relevance in cardiovascular pathologies. For that purpose, two experimental systems were employed: an adenoviral NOX5-β overexpression model in immortalized human aortic endothelial cells (TeloHAEC) and a chronic infarction in vivo model developed from a conditional endothelial NOX5 knock-in mouse. NOX5 increased cyclooxygenase-2 isoform (COX-2) expression and prostaglandin E2 (PGE2) production through nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) in TeloHAEC. Protein kinase C (PKC) activation and intracellular calcium level (Ca++) mobilization increased ROS production and NOX5 overexpression, which promoted a COX-2/PGE2 response in vitro. In the chronic infarction model, mice encoding endothelial NOX5 enhanced the cardiac mRNA expression of COX-2 and PGES, suggesting a COX-2/PGE2 response to NOX5 presence in an ischemic situation. Our data support that NOX5-derived ROS may modulate the COX-2/PGE2 axis in endothelial cells, which might play a relevant role in the pathophysiology of heart infarction.

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Section: Discussionmentioning

confidence: 99%

Induction of Cyclooxygenase-2 by Overexpression of the Human NADPH Oxidase 5 (NOX5) Gene in Aortic Endothelial Cells

Marqués

Cortés

Pejenaute

et al. 2020

Cells

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“…In the year 1898, Tigerstedt and Bergman discovered renin to be the rate-limiting enzyme and the first recognized component of RAS [1]. At first, the RAS was thought to be a sequence of many enzymatic steps, eventually producing a single bioactive metabolite, Angiotensin II (AngII) [2,13]. However, in recent years, the identification of novel enzymes and receptors has magnified the classical view of the RAS [14,15].…”

Section: A Brief Overview Of Rasmentioning

confidence: 99%

“…AngII is considered to be the finical production of the classic RAS [2,13]. It has a direct role in the cardiovascular, damage of the glucose transport system [3], and insulin resistance [80].…”

Section: Angii and Ampkmentioning

confidence: 99%

AMPK: a balancer of the renin–angiotensin system

Liu

et al. 2019

Bioscience Reports

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The renin–angiotensin system (RAS) is undisputedly well-studied as one of the oldest and most critical regulators for arterial blood pressure, fluid volume, as well as renal function. In recent studies, RAS has also been implicated in the development of obesity, diabetes, hyperlipidemia, and other diseases, and also involved in the regulation of several signaling pathways such as proliferation, apoptosis and autophagy, and insulin resistance. AMP-activated protein kinase (AMPK), an essential cellular energy sensor, has also been discovered to be involved in these diseases and cellular pathways. This would imply a connection between the RAS and AMPK. Therefore, this review serves to draw attention to the cross-talk between RAS and AMPK, then summering the most recent literature which highlights AMPK as a point of balance between physiological and pathological functions of the RAS.

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“…In the present study, we found four differentially expressed endogenous peptides derived from PKD1 mapped to the functional domains of this protein (Table 2). It is known that cleavage of precursor proteins by proteases generates peptides that may gain specialized functions not ascribed to their precursors, which could reflect the state of a cell under certain physiological conditions or pathological processes [36]. Therefore, it is reasonable to believe that although the functions of these PKD1-derived peptides may not have a strong association with their precursor protein, these peptides may play an important role in the early prediction of GDM.…”

Section: Discussionmentioning

confidence: 98%

Early Second-Trimester Peptidomic Identification of Serum Peptides for Potential Prediction of Gestational Diabetes Mellitus

Yin

Huai

Zhao

et al. 2018

Cell Physiol Biochem

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Background/Aims: Early screening and diagnosis is important for minimizing gestational adverse outcomes. Routine screening of gestational diabetes mellitus (GDM) at 24–28 weeks with 75 g oral glucose challenge test (OGCT) leaves limited time for intervention and prevention. This study aims to analyze maternal serum peptides in the early second-trimester for prediction of gestational diabetes mellitus (GDM). Methods: Serum samples were collected from 16-18-week pregnant women that visited Nanjing Maternity and Child Health Care Hospital from April to August 2015. According to gestational outcome with or without GDM in late pregnancy, 200 of serum samples from GDM mothers and controls were randomly divided into two subgroups. Peptidomic identification of serum peptides was performed by combining ultrafiltration and liquid chromatography-tandem mass spectrometry (LC-MS/MS) to investigate the differentially-expressed peptides between two groups. Results: A total of 297 identified peptides, originating from 228 proteins, were significantly differentially expressed in the GDM group compared with control. These precursor proteins may play critical roles in cell death of cortical neurons, elongation of cellular protrusions, and stabilization of microtubules. Major networks identified included those involving lipid metabolism, molecular transport and small molecule biochemistry. Conclusion: We provide for the first time a validated peptidome profile of early second-trimester serum in normal and GDM mothers, and we investigated the potential serum biomarkers for GDM. We concluded that 297 peptides could serve as potential biomarkers for GDM.

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Hypertension regulating angiotensin peptides in the pathobiology of cardiovascular disease

Cited by 48 publications

References 83 publications

Induction of Cyclooxygenase-2 by Overexpression of the Human NADPH Oxidase 5 (NOX5) Gene in Aortic Endothelial Cells

Induction of Cyclooxygenase-2 by Overexpression of the Human NADPH Oxidase 5 (NOX5) Gene in Aortic Endothelial Cells

AMPK: a balancer of the renin–angiotensin system

Early Second-Trimester Peptidomic Identification of Serum Peptides for Potential Prediction of Gestational Diabetes Mellitus

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