Hypertension-related hypoalgesia, autonomic function and spontaneous baroreflex sensitivity

The role of ischaemia and pain in the blood pressure response to exercise stress testing in patients with coronary heart disease

“…Although the current study suggests that the baroreflex may be the mechanism linking pain and blood pressure, our study design prevents us from determining whether this is due to a peripheral or central effects. Although previous research, in non-exercise settings, has suggested a central effect of baroreflex stimulation, [36][37][38] it is also possible that there may be a direct peripheral mechanism, a pathway that cannot be discounted by the current study. This is further complicated by the inherent problems of measuring spontaneous baroreflex sensitivity during exercise (i.e., the inability to measure the full function curve).…”

“…In concordance with this, previous research has found links between baroreflex sensitivity and the hypertension-hypoalagesia phenomenon. [36][37][38] For example, cardiac cycle synchronized acute baroreceptor stimulation 37 and natural activation of baroreceptors 36 produced decreased pain perception in humans. However, it is also possible that other mechanisms, possibly in conjunction with baroreflex dysregulation, may play a role in the blood pressure-pain relationship.…”

Nociceptive flexion reflex thresholds and pain during rest and computer game play in patients with hypertension and individuals at risk for hypertension

“…In humans, the evidence in favour of opioid dysfunction is mostly negative (e.g., Bruehl et al, 2002;France et al, 2005;Ring et al, 2007;Schobel et al, 1998;cf. McCubbin and Bruehl, 1994;McCubbin et al, 2006) whereas the evidence for baroreceptor activation is more mixed (e.g., al 'Absi et al, 2005;Edwards et al, 2001Edwards et al, ,2003aGuasti, Zanotta, Mainardi, et al, 2002;McIntyre et al, 2006;Rau et al, 1995). Although the current experiments were designed to investigate the function of the descending pain modulation systems in essential hypertension and risk for hypertension, results indicated that there were no differential effects on nociception or pain.…”

O efeito da música no estresse de pacientes adultos durante cirurgias odontológicas: estudo randomizado, caso-controle e multiparamétrico

“…Alguns autores comentam que pacientes hipertensos costumam ter menos sensibilidade ao estímulo de dor que normotensos como Bavitz (2006), Guasti et al (1999), Guasti et al (2002). Segundo Guasti et al (1999) quanto maior a elevação da pressão arterial menor a reação do indivíduo ao estímulo de dor.…”

“…Segundo Guasti et al (1999) quanto maior a elevação da pressão arterial menor a reação do indivíduo ao estímulo de dor. Os autores ainda concordam que na hipoalgesia associada a hipertensão possa estar relacionada a mecanismos comuns de estímulo nervoso e de aumento pressórico fundamentado na modulação da percepção de dor por via baroreflexa (Guasti et al, 2002). …”