Background and Purpose
Acute triggers for ischemic stroke, which may include infection, are understudied, as is whether background cardiovascular disease (CVD) risk modifies such triggering. We hypothesized that infection increases acute stroke risk, especially among those with low CVD risk.
Methods
Hospitalized strokes and infections were identified in the Atherosclerosis Risk in Communities (ARIC) cohort. A case-crossover design and conditional logistic regression were used to compare hospitalized infections among stroke patients (14, 30, 42, and 90 days before stroke) with corresponding control periods 1 year and 2 years prior. Background CVD risk was assessed at both visit 1 and the visit most proximal to stroke, with risk dichotomized at the median.
Results
A total of 1,008 adjudicated incident ischemic strokes were included. Compared to control periods, hospitalized infection was more common within 2 weeks before stroke (14 day odds ratio (OR) = 7.7 (2.1, 27.3)); the strength of association declined with increasing time in the exposure window before stroke (30 day OR = 5.7 (2.3, 14.3), 42 day OR = 4.5 (2.0, 10.2), and 90 day OR = 3.6 (2.1, 6.5)). Stroke risk was higher among those with low compared with high CVD risk, with this interaction reaching statistical significance for some exposure periods.
Conclusions
These results support the hypothesis that hospitalized infection is a trigger of ischemic stroke, and may explain some cryptogenic strokes. Infection control efforts may prevent strokes. CVD preventive therapies may prevent strokes if used in the peri-infection period but clinical trials are needed.