Hypertensive urgencies during the first wave of COVID-19 pandemic in a tertiary hospital setting: A “U” shaped alarming curve.

Leontsinis, Ioannis; Katsiki, Niki; Papademetriou, Vasilios; Chrysοhoou, Christina; Kariori, Maria; Dalakouras, Ioannis; Tolis, P.; Fragoulis, Christos; Kalos, Theodoros; Tatakis, Fotios-Panagiotis; Dimitriadis, Kyriakos; Doumas, Michael; Sambatakou, Helen; Pirounaki, Maria; Mihas, Constantinos; Bhaskar, Sonu; Tsivgoulis, Georgios; Tousoulis, Dimitrios; Banach, Maciej; Tsioufis, Κonstantinos

doi:10.5114/aoms/141243

Cited by 8 publications

(10 citation statements)

References 70 publications

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“…Acute hypertensive disorders are serious medical conditions, with a combined prevalence of 1.2% of total admission in the ED, in the most recent meta-analysis on the topic [ 1 ]. In the present prospective study, it is difficult to estimate the true prevalence of these conditions, considering the changes in the ED admissions dictated by the COVID-19 pandemic [ 22 , 23 ]. Our data correspond to a prevalence of 0.09% for HU and 0.02% for HE; much lower prevalences compared to literature data, which could partly account for the truth regarding the lower number of ED admissions during the pandemic, but could also be the result of underestimation of data due to enrollment issue for logistical difficulties that have affected all italian hospitals in recent years.…”

Section: Discussionmentioning

confidence: 99%

Hypertensive emergencies and urgencies: a preliminary report of the ongoing Italian multicentric study ERIDANO

et al. 2023

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Hypertensive urgencies (HU) and hypertensive emergencies (HE) are challenges for the Emergency Department (ED). A prospective multicentre study is ongoing to characterize patients with acute hypertensive disorders, prevalence of subclinical hypertension-mediated organ damage (HMOD), short- and long-term prognosis; this is a preliminary report. Patients admitted to the ED with symptomatic blood pressure (BP) ≥180/110 mmHg were enrolled. They were managed by ED personnel according to their clinical presentations. Subsequently they underwent clinical evaluation and subclinical HMOD assessment at a Hypertension Centre within 72 h from enrolment. 122 patients were included in this report. Mean age was 60.7±13.9 years, 52.5% were females. 18 (14.8%) patients were diagnosed with HE, 108 (88.5%) with HU. There were no differences in gender, BMI, and cardiovascular comorbidities between groups. At ED discharge, 66.7% and 93.6% ( p = 0.003) of HE and HU patients, respectively, had BP < 180/110 mmHg. After 72 h, 34.4% of patients resulted normotensive; 35.2%, 22.1%, and 8.2% had hypertension grade 1, 2, and 3, respectively. Patients with uncontrolled BP at office evaluation had higher vascular HMOD (49.1 vs. 25.9%, p = 0.045). Cardiac (60 vs. 34%, p = 0.049), renal (27.8 vs. 9.6%, p = 0.010) and cerebral (100 vs. 21%, p < 0.001) HMOD was more frequent in HE compared to HU group. HE showed greater cardiac, renal, and cerebral subclinical HMOD, compared to HU. 72-hours BP control is not associated with different HMOD, except for vascular HMOD; therefore, proper comprehensive examination after discharge from the ED could provide added value in cardiovascular risk stratification of such patients. One third of patients with acute blood pressure rise evaluated to the ED resulted normotensive at office evaluation (<72 hours after discharge). Patients with hypertensive emergency showed greater cardiac, renal, and cerebral subclinical HMOD, compared to the patients with hypertensive urgency. BP: blood pressure; HMOD: hypertension-mediated organ damage; y.o.: years old; mo.: months.

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Section: Discussionmentioning

confidence: 99%

Hypertensive emergencies and urgencies: a preliminary report of the ongoing Italian multicentric study ERIDANO

et al. 2023

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“…This is consistent with a number of observations that unequivocally indicate that the female gender has a higher risk of developing long COVID syndrome. This is supported by data both from Poland and from numerous meta-analyses P r e p r i n t [6,25,26]. For example, a meta-analysis conducted by Vasiliki Tsampasian et all.…”

Section: Discussionmentioning

confidence: 67%

"LC Risk Score" - development and evaluation of a scale for assessing the risk of developing long COVID

Babicki,

Lejawa,

Osadnik

et al. 2024

Arch Med Sci

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IntroductionObjective: To create a valuable practical tool for evaluating the risk of LC development.Material and methods1150 patients from the Polish STOP-COVID registry (PoLoCOV study) were used to develop the risk score. The patients were ill between 03/2020 and 04/2022. To develop a clinically useful scoring model. The LC risk score was generated using the machine learning-based framework AutoScore. Patient data were first randomised into a training (70% of output) and a test (30% of output) cohorts. Due to relatively small study group, cross-validation was used. Model predictive ability was evaluated based on the ROC curve and the AUC value. The result of the risk score for a given patient was the total value of points assigned to selected variables.ResultsTo create long COVID Risk Score, eight variables were ultimately selected due to their significance and clinical value. Female gender significantly contributed to higher final outcome values, with age range 40-49, BMI <18.5 kg/m2, hospitalisation during active disease, arthralgia, myalgia as well as loss of taste and smell during infection, COVID-19 symptoms lasting at least 14 days, and unvaccinated status. The final predictive value of the developed LC risk score for a cut-off of 58 points was AUC=0.630 (95% CI: 0.571-0.688) with sensitivity - 39.80%, specificity - 85.1%, positive predictive value - 80.8%, and negative predictive value 47.3%.ConclusionsConclusions: The LC risk score might be a practical and undemanding utility that employs basic sociodemographic data, vaccination status, and symptoms during COVID-19 to assess the risk of long-COVID.

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“…However, oral administration of antihypertensive drugs should be performed immediately to evaluate and monitor possible target organ damage, such as to the heart, brain, and kidney, and also to determine the possible cause of blood pressure increase. 27–30 …”

Section: Discussionmentioning

confidence: 99%

Effect of Sleep Duration on Blood Pressure in Patients with SARS-CoV-2 Infection and Hypertensive Urgencies in Shanghai Fangcang Shelter Hospital

Shi¹,

Ding²,

Hu³

et al. 2023

IDR

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Objective To evaluate the effect of sleep duration on blood pressure in patients with hypertension urgencies combined with SARS-CoV-2 infection in a Fangcang shelter hospital. Methods From April 10, 2020 to May 20, 2022, we statistically analyzed the blood pressure and sleep conditions of 52 patients with combined hypertension urgencies and SARS-CoV-2 infection admitted in Shanghai National Convention and Exhibition Center Fangcang shelter hospital. They were divided into the short-term (daily sleep duration: <7 h) and normal sleep group (7–9 h). We performed a comparison of the control effects of basic antihypertensive drugs. Additionally, patients in the short-term sleep group underwent drug therapy for sleep regulation and continuous monitoring of blood pressure. Results Among these patients, the blood pressure was higher in the short-term sleep group than that of the normal sleep group, and also more difficult to control ( p <0.05). Furthermore, the blood pressure of the patients in the short-term sleep group was more easily controlled after treatment with drugs for sleep regulation and basic antihypertensive drugs ( p <0.05). Conclusion The blood pressure level in patients with combined SARS-CoV-2 infection and hypertension urgencies was higher in those with a shorter duration of daily sleep, and also more difficult to control in Fangcang shelter hospital. Drug therapy for sleep regulation should be administered early to obtain sufficient blood pressure control effects.

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Hypertensive urgencies during the first wave of COVID-19 pandemic in a tertiary hospital setting: A “U” shaped alarming curve.

Cited by 8 publications

References 70 publications

Hypertensive emergencies and urgencies: a preliminary report of the ongoing Italian multicentric study ERIDANO

Hypertensive emergencies and urgencies: a preliminary report of the ongoing Italian multicentric study ERIDANO

"LC Risk Score" - development and evaluation of a scale for assessing the risk of developing long COVID

Effect of Sleep Duration on Blood Pressure in Patients with SARS-CoV-2 Infection and Hypertensive Urgencies in Shanghai Fangcang Shelter Hospital

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