Hyperthermia classic commentary: ‘Arrhenius relationships from the molecule and cell to the clinic’ by William Dewey,<b><i>Int. J. Hyperthermia</i></b>, 10:457–483, 1994

Retired, William C. Dewey; Diederich, Chris J.

doi:10.1080/02656730902733695

Cited by 31 publications

(32 citation statements)

References 36 publications

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“…(21)(22)(23)(24)(25)(26)(27)(28) Research has revealed that protein denaturization is a key biologic effect of hyperthermia at modest temperature elevations. (29) The activation energeries for protein denaturization and heat induced cell death were noted to be within the same range. Further research suggested that nuclear proteins are most sensitive (30)(31)(32) and a high degree of correlation of nuclear protein aggregation and heat induced cell kill has been noted.…”

Section: Mechanism Of Cell Death With Hyperthermiamentioning

confidence: 90%

Hyperthermia, Radiation and Chemotherapy: The Role of Heat in Multidisciplinary Cancer Care

Hurwitz

Stauffer

2014

Seminars in Oncology

123

104

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Section: Mechanism Of Cell Death With Hyperthermiamentioning

confidence: 90%

Hyperthermia, Radiation and Chemotherapy: The Role of Heat in Multidisciplinary Cancer Care

Hurwitz

Stauffer

2014

Seminars in Oncology

123

104

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“…Heating-induced damage is not linear in the input power, with small increases in temperature above an onset threshold causing rapid increases in damage, likened to the activation energy of other chemical processes (Dewey 2009). We reasoned that reducing illumination duty cycle to periods much shorter than the time to reach steady state would reduce the peak temperature achieved, permitting higher optical powers with less heating damage.…”

Section: Resultsmentioning

confidence: 99%

Brain heating induced by near-infrared lasers during multiphoton microscopy

Podgorski

Ranganathan

2016

Journal of Neurophysiology

250

234

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Podgorski K, Ranganathan G. Brain heating induced by nearinfrared lasers during multiphoton microscopy. J Neurophysiol 116: 1012-1023, 2016. First published June 8, 2016 doi:10.1152/jn.00275.2016.-Two-photon imaging and optogenetic stimulation rely on high illumination powers, particularly for stateof-the-art applications that target deeper structures, achieve faster measurements, or probe larger brain areas. However, little information is available on heating and resulting damage induced by high-power illumination in the brain. In the current study we used thermocouple probes and quantum dot nanothermometers to measure temperature changes induced by two-photon microscopy in the neocortex of awake and anaesthetized mice. We characterized heating as a function of wavelength, exposure time, and distance from the center of illumination. Although total power is highest near the surface of the brain, heating was most severe hundreds of micrometers below the focal plane, due to heat dissipation through the cranial window. Continuous illumination of a 1-mm 2 area produced a peak temperature increase of ϳ1.8°C/100 mW. Continuous illumination with powers above 250 mW induced lasting damage, detected with immunohistochemistry against Iba1, glial fibrillary acidic protein, heat shock proteins, and activated caspase-3. Higher powers were usable in experiments with limited duty ratios, suggesting an approach to mitigate damage in high-power microscopy experiments.

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“…For example, Dewey [9] noted previous unsuccessful attempts to use the thermal isoeffect dose to describe secondary physiological responses to thermal damage, e.g. oedema, or thermal exposures needed to produce thermal coagulation in some tissues ex vivo.…”

Section: Thermal Damage To Tissuesmentioning

confidence: 99%

“…CEM43 provides a convenient way to characterise time-temperature exposure combinations resulting in a specific level of thermal damage, and is a useful alternative to specifying rate coefficients A and E a in Equation 1. The isodose concept has been applied to various biological endpoints, from clonogenic survival curves for cell suspensions to thermal damage to tissue, and has been used for developing exposure to ultrasound and radiofrequency energy and power standards for magnetic resonance imaging as well as therapeutic applications including hyperthermia for treatment of cancer and radiofrequency ablation [9]. One recent example was a prediction of optimal temperatures of hot beverages to minimise risk of burns from spilled liquids [10].…”

Section: Thermal Damage To Tissuesmentioning

confidence: 99%

Thermal aspects of exposure to radiofrequency energy: Report of a workshop

Foster

Morrissey

2011

International Journal of Hyperthermia

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This special issue contains papers presented at an international workshop entitled 'Thermal Aspects of Radio Frequency Exposure' convened in Gaithersburg, Maryland, USA on 11-12 January 2010, and co-sponsored by the Mobile Manufacturers Forum, the GSM Association, and the US Food and Drug Administration. The goals of the workshop were to (1) identify appropriate health endpoints associated with thermal hazards and their time-dependence thresholds, and (2) outline future directions for research that might lead to an improved understanding of health and safety implications of human exposure to radiofrequency energy and design of improved exposure limits for this energy. This present contribution summarises some of the major conclusions of the speakers, and offers comments by one of the present authors on proposed research priorities and the implications of the material presented at the workshop for setting improved thermally based limits for human exposure to RF energy.

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Hyperthermia classic commentary: ‘Arrhenius relationships from the molecule and cell to the clinic’ by William Dewey,Int. J. Hyperthermia, 10:457–483, 1994

Cited by 31 publications

References 36 publications

Hyperthermia, Radiation and Chemotherapy: The Role of Heat in Multidisciplinary Cancer Care

Hyperthermia, Radiation and Chemotherapy: The Role of Heat in Multidisciplinary Cancer Care

Brain heating induced by near-infrared lasers during multiphoton microscopy

Thermal aspects of exposure to radiofrequency energy: Report of a workshop

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