2020
DOI: 10.3390/pharmaceutics12111097
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Hyperthermia-Induced Controlled Local Anesthesia Administration Using Gelatin-Coated Iron–Gold Alloy Nanoparticles

Abstract: The lack of optimal methods employing nanoparticles to administer local anesthesia often results in posing severe risks such as non-biocompatibility, in vivo cytotoxicity, and drug overdose to patients. Here, we employed magnetic field-induced hyperthermia to achieve localized anesthesia. We synthesized iron–gold alloy nanoparticles (FeAu Nps), conjugated an anesthetic drug, Lidocaine, and coated the product with gelatin to increase the biocompatibility, resulting in a FeAu@Gelatin–Lidocaine nano-complex forma… Show more

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Cited by 3 publications
(3 citation statements)
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“…Plasmonic nanomaterials also demonstrated biomedical applications in phototherapy [23][24][25][26][27][28]. Based on strong photothermal effects, plasmonic gold nanomaterials have been intensively investigated for cancer therapy, wound healing, and antibacterial applications [29][30][31][32][33]. For example, a plasmonic gold nanocage-based anticancer nanoplatform that was photothermally responsive in the near-infrared (NIR) region was employed to treat MCF-7 tumors [34].…”
Section: Introductionmentioning
confidence: 99%
“…Plasmonic nanomaterials also demonstrated biomedical applications in phototherapy [23][24][25][26][27][28]. Based on strong photothermal effects, plasmonic gold nanomaterials have been intensively investigated for cancer therapy, wound healing, and antibacterial applications [29][30][31][32][33]. For example, a plasmonic gold nanocage-based anticancer nanoplatform that was photothermally responsive in the near-infrared (NIR) region was employed to treat MCF-7 tumors [34].…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, NPs of magnetic metal alloys were used to optimize the magnetic properties. For the MHT needs, as magnetic agents Fe [52], Co [53] NPs and Fe-Ni-Co [54], Co-Ni [55], Fe-Au [56][57][58], Fe-Al [59], Fe-Rh [60], Fe-Cr-Nb-B [61], Cu-Fe and Cu-Ni [62] alloys are considered. The potential chemical instability and toxicity of Co and Ni limit their use.…”
Section: Types Of Mnps Suitable For Ht and Their Requirementsmentioning
confidence: 99%
“…In this procedure, which has recently seen rapid development, magnetic nanomaterials can be used to improve hyperthermia efficiency compared to traditional hyperthermia methods for the erosion of tumors [97][98][99][100][101][102][103][104][105][106]. The most significant aspect of magnetic hyperthermia is that magnetic nanomaterials are distributed over very small areas so that the temperature behavior of healthy cells is not affected [107][108][109]. For this purpose, the highest possible saturation magnetization can be achieved with multifunctional iron oxide-based magnetic nanomaterials used on the specific therapeutic side of cancer cells.…”
Section: Magnetic Hyperthermiamentioning
confidence: 99%