Hyperthermia-induced stellate cell deactivation to enhance dual chemo and pH-responsive photothermal therapy for pancreatic cancers

Hu, Qinglian; Xu, Minjie; Feng, Jie; Xie, Hui; Li, Jingyu; He, Ying; Tang, Guping; Guo, Bing

doi:10.1039/d2nr04235e

Cited by 13 publications

(9 citation statements)

References 51 publications

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“…To quantitatively evaluate the photothermal conversion ability of V( iv ) NPs, the photothermal conversion efficiency ( η ) was measured by a previously established method. 23 The η value was calculated as ∼28.5% under irradiation with an 808 nm laser (Fig. S7†), suggesting that V( iv ) NPs can convert NIR energy to heat.…”

Section: Resultsmentioning

confidence: 99%

Stimuli-responsive ultra-small vanadate prodrug nanoparticles with NIR photothermal properties to precisely inhibit Na/K-ATPase for enhanced cancer therapy

Wang

Tang

et al. 2023

Nanoscale

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Section: Resultsmentioning

confidence: 99%

Stimuli-responsive ultra-small vanadate prodrug nanoparticles with NIR photothermal properties to precisely inhibit Na/K-ATPase for enhanced cancer therapy

Wang

Tang

et al. 2023

Nanoscale

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“…[94] Similarly, CTh (2,3,3-trimethyl-5-(thiophen-2-yl)-3H-indole) was synthesized as a photothermal therapy (PTT) compound designed for acid-activated absorbance. [236] CTh, when combined with GEM, was encapsulated within lipid NPs (C-G NPs). In vitro experiments assessing the PCE of CTh NPs revealed their ability to reach temperatures exceeding 75 °C under specific conditions while maintaining thermal stability when exposed to NIR laser irradiation.…”

Section: Multi-stimuli Responsive Nanomaterialsmentioning

confidence: 99%

“…PTT further influenced the TME by reducing collagen content and ECM components while suppressing the expression of TGF-𝛽1, alpha-smooth muscle actin (𝛼-SMA), and collagen I in tumor tissues. [236] Photo/thermo/pH-responsive NPs were also prepared for the delivery of DOX to pancreatic cancer tissue. [237] Here, porous polypyrrole NPs (PPy NPs) were synthesized through a templateguided chemical oxidation method, where octylamine (OTA) and polyvinylpyrrolidone (PVP) formed spherical micelles as templates for the subsequent PPy polymerization.…”

Section: Multi-stimuli Responsive Nanomaterialsmentioning

confidence: 99%

Responsive Nanomaterial Delivery Systems for Pancreatic Cancer Management

Elsherbeny,

Bayraktutan,

et al. 2023

Advanced Therapeutics

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Pancreatic cancer is characterized by a high mortality rate and unfavorable prognosis. This is primarily attributed to poor accumulation of therapeutic agents at the target site due to the presence of a highly complex tumor microenvironment surrounding the pancreatic cancer tissue. However, a promising avenue for targeted drug delivery has emerged in the form of stimuli‐responsive materials. These advanced nanocarriers, encompassing both external and internal stimuli‐responsive nanoparticles, can be formulated to control the release of therapeutic agents precisely in response to specific activation. By harnessing external stimuli such as light, ultrasound, or magnetic fields, as well as intrinsic biological triggers including pH, redox potential, hypoxia, and temperature, these nanomaterials exhibit ‘intelligent’ and selective responses within complex biological environments. These responsive nanoparticles have been shown to address challenges associated with poor vascularity and thick desmoplastic stromal layers, which are hallmarks of pancreatic cancer, by promoting enhanced drug accumulation and release at the target site relative to conventional therapy. This work explores the design strategies for advanced stimuli‐responsive nanomaterials, integrating both internal and external stimuli, with the potential to enhance drug delivery efficacy in pancreatic cancer. It addresses the challenges and prospects in their development and offers insights for future clinical applications.

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“…[13][14][15] Numerous excellent photothermal platforms have been reported, such as indocyanine green (ICG), [16] porphyrin, [17] CH1055, [18,19] chlorin e6 (Ce6), [20] and organic molecules. [21,22] Among many near-infrared (NIR) dyes having photo-therapeutic effects, only indocyanine green is clinically available. Recently, many approaches based on nanotechnology have been used to solve the physicochemical problems such as poor stability and aggregation of ICG.…”

Section: Introductionmentioning

confidence: 99%

Mitochondria Targeted Nanoparticles Potentiate Tumor Chemo‐Phototherapy by Toxic Oxidative Stress Mediated Oxeiptosis

Chen

et al. 2023

Macromolecular Bioscience

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Insufficient accumulation of drug at the tumor site and the low drug response are the main reason for the unsatisfactory effect of cancer therapy. Delivery drugs exquisitely to subcellular level can be employed to reduce side effects, and expand the therapeutic window. Herein, a triphenylphosphine (TPP) modified lipid nanoparticles is designed which are loaded with the photosensitizer indocyanine green (ICG) and chemotherapeutic paclitaxel (PTX) for mitochondria‐targeted chemo‐phototherapy. Owing to the movement of majority mitochondria along microtubules in cytoplasm, mitochondrial targeting may enable PTX to act more effectively. Meanwhile, the existence of chemo‐drug potentiates the phototherapy to achieve synergistic anti‐tumor activity. As expected, mitochondria targeting nanomedicine (M‐ICG‐PTX NPs) showed improved mitochondria targeted cellular distribution and enhanced cell cytotoxicity in vitro. Also, M‐ICG‐PTX NPs exhibited higher tumor growth inhibition ability by promoting cell apoptosis and oxeiptosis pathway, and high effective inhibition of primary tumor growth and tumor metastasis. Taken together, M‐ICG‐PTX NPs may be promising nanoplatforms to achieve potent therapeutic effect for the combination of chemo‐ and photo‐therapy (PTT).

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Hyperthermia-induced stellate cell deactivation to enhance dual chemo and pH-responsive photothermal therapy for pancreatic cancers

Abstract: For pancreatic ductal adenocarcinoma (PDAC) treatment, deactivation of pancreatic stellate cells (PSCs) through blockage of transforming growth factor β (TFG-β) pathway is a promising strategy to inhibit stroma, enhance drug...

Cited by 13 publications

References 51 publications

Stimuli-responsive ultra-small vanadate prodrug nanoparticles with NIR photothermal properties to precisely inhibit Na/K-ATPase for enhanced cancer therapy

Stimuli-responsive ultra-small vanadate prodrug nanoparticles with NIR photothermal properties to precisely inhibit Na/K-ATPase for enhanced cancer therapy

Responsive Nanomaterial Delivery Systems for Pancreatic Cancer Management

Mitochondria Targeted Nanoparticles Potentiate Tumor Chemo‐Phototherapy by Toxic Oxidative Stress Mediated Oxeiptosis

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