Hyperthermia-induced vascular injury in normal and neoplastic tissue

Badylak, Stephen F.; Babbs, Charles F.; Skojac, Teresa M.; Voorhees, William D.; Richardson, Ralph C.

doi:10.1002/1097-0142(19850901)56:5<991::aid-cncr2820560503>3.0.co;2-5

Cited by 57 publications

(10 citation statements)

References 24 publications

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“…The results in the present study indicate that SNP infusion should not be given if muscle temperatures above 43.08C are measured during HT, to avoid a further increase in muscle temperature. At this temperature, there is an imminent danger of muscle necrosis, even without the use of SNP, as shown in experiment F. This ®nding is in accordance with what has been reported by Badylak et al 17 , who found necrosis of skeletal muscle after microwave-induced HT at 438C for 30 min.…”

Section: Discussionsupporting

confidence: 92%

Use of the vasodilator sodium nitroprusside to increase tumour temperature during loco-regional hyperthermia with a capacitive ring applicator in a rat tumour model

Krossnes

Hornsleth

2002

International Journal of Hyperthermia

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The influence of sodium nitroprusside (SNP) induced hypotension (to a mean arterial pressure of 60 mmHg) on tumour and normal tissue temperature during hyperthermia (HT) was examined. Loco-regional HT was given to the calf of BD IX rats by external radiofrequency heating from a capacitive ring applicator. In experiments in rats with subcutaneous BT(4)An tumours, the mean tumour temperature increased by 0.49 degrees C from 42.36 to 42.85 degrees C, on average, during SNP-hypotension. This represented 58% of the increase in tumour temperature found in the same rats when the tumour circulation was stopped completely by sacrificing the rats. SNP-hypotension resulted in a decrease in mean muscle temperature from 41.73 to 41.23 degrees C. The temperature difference between the tumour and the underlying muscle thereby increased by approximately 1 degrees C, indicating that SNP can increase tumour temperature during HT without increasing the risk of heat-related damage to skeletal muscle. Experiments in rats without tumours were also done to further examine the effect of SNP-hypotension on muscle temperature under different treatment conditions (variation of radiofrequency energy deposition and water bolus temperature). It was found that SNP decreased the muscle temperature during HT in two experiments where the average muscle temperature was 42.1 and 42.6 degrees C, respectively. In an experiment where the muscle temperature was 43.0 degrees C, on average, before SNP infusion, the muscle temperature increased during SNP-hypotension. This finding indicates that SNP-hypotension during HT may increase the risk of skeletal muscle necrosis with muscle temperatures at this level.

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Section: Discussionsupporting

confidence: 92%

Use of the vasodilator sodium nitroprusside to increase tumour temperature during loco-regional hyperthermia with a capacitive ring applicator in a rat tumour model

Krossnes

Hornsleth

2002

International Journal of Hyperthermia

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“…As an example, Coleman et al [ 10 ] studied regional hyperthermia in which the tumour tissue has been heated to keep its temperature above 42°C for a few hours. However, among the concurrent treatments of cancer, hyperthermia seems to be the less developed in the clinical practice [ 11 – 13 ]. One reason may be the difficulty of targeting sufficient amounts of heat to the tumour tissue only.…”

Section: Introductionmentioning

confidence: 99%

Modelling mass and heat transfer in nano-based cancer hyperthermia

2015

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We derive a sophisticated mathematical model for coupled heat and mass transport in the tumour microenvironment and we apply it to study nanoparticle delivery and hyperthermic treatment of cancer. The model has the unique ability of combining the following features: (i) realistic vasculature; (ii) coupled capillary and interstitial flow; (iii) coupled capillary and interstitial mass transfer applied to nanoparticles; and (iv) coupled capillary and interstitial heat transfer, which are the fundamental mechanisms governing nano-based hyperthermic treatment. This is an improvement with respect to previous modelling approaches, where the effect of blood perfusion on heat transfer is modelled in a spatially averaged form. We analyse the time evolution and the spatial distribution of particles and temperature in a tumour mass treated with superparamagnetic nanoparticles excited by an alternating magnetic field. By means of numerical experiments, we synthesize scaling laws that illustrate how nano-based hyperthermia depends on tumour size and vascularity. In particular, we identify two distinct mechanisms that regulate the distribution of particle and temperature, which are characterized by perfusion and diffusion, respectively.

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“…Two sessions of hyperthermia at 43°C or 45°C for implanted tumors in rats caused no change in the temperature of the surrounding normal tissue but did induce an increase in the intratumoral steady‐state temperature. These two sessions of hyperthermia caused thrombosis in 90% of the intratumoral tissue 21…”

Section: Discussionmentioning

confidence: 99%

“…Chronic hypoxic and necrotic areas in the tumor may be increased relative to prehyperthermia, and midtherapy CT studies showed a statistically significant reduction in ΔCT max in CR patients. As shown by histologic changes due to hyperthermia in experimental and human tumors, vascular damage is prominent in the tumor center, whereas damage to the surrounding normal tissue is small 21–23. This suggests that the issue of hypoxic cells may not be critical.…”

Section: Discussionmentioning

confidence: 99%

Dynamic computed tomography predicts tumor temperature and response to thermoradiotherapy in superficial and subsurface tumors

Nagata

Murata

Shiga

et al. 1999

Cancer

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BACKGROUND Dynamic computed tomography (CT) was performed on patients undergoing thermoradiotherapy for superficial or subsurface tumors, and the correlation between tumor enhancement and tumor temperature during hyperthermia was evaluated. The authors further investigated whether tumor enhancement by dynamic CT is predictive of tumor response to thermoradiotherapy. METHODS Thermoradiotherapy was given to 26 patients. Radiotherapy consisted of 40–70 gray. Hyperthermia was conducted over 3–5 sessions, and tumor temperature was measured at each session. Dynamic CT was performed prehyperthermia (within 1 week before the initiation of hyperthermia) and midtherapy (within 1 week after 2 sessions of hyperthermia). RESULTS A complete response (CR) was obtained in 11 patients (42%) and either a partial response or no response (non‐CR) in 15 (58%). There was no correlation between tumor enhancement obtained by prehyperthermia CT and tumor temperature parameters or response. However, the ΔCTmax (maximum increased enhancement) by prehyperthermia and midtherapy CT was 39.0 ± 18.9 HU and 26.1 ± 14.2 HU, respectively, in CR patients, and 46.4 ± 21.1 HU and 49.6 ± 19.1 HU, respectively, in non‐CR patients. This change in ΔCTmax at midtherapy was significantly different between groups (P < 0.01). The ΔCTmax ratio for prehyperthermia and midtherapy CT studies correlated with the average tumor temperature (P < 0.05). CONCLUSIONS Tumor enhancement by prehyperthermia and midtherapy dynamic CT predicted tumor temperature during hyperthermia and response to thermoradiotherapy for superficial or subsurface malignancies. Cancer 1999;86:177–85. © 1999 American Cancer Society.

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Hyperthermia-induced vascular injury in normal and neoplastic tissue

Cited by 57 publications

References 24 publications

Use of the vasodilator sodium nitroprusside to increase tumour temperature during loco-regional hyperthermia with a capacitive ring applicator in a rat tumour model

Use of the vasodilator sodium nitroprusside to increase tumour temperature during loco-regional hyperthermia with a capacitive ring applicator in a rat tumour model

Modelling mass and heat transfer in nano-based cancer hyperthermia

Dynamic computed tomography predicts tumor temperature and response to thermoradiotherapy in superficial and subsurface tumors

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