Hyperthermia Is Now Included in the NCCN Clinical Practice Guidelines for Breast Cancer Recurrences: An Analysis of Existing Data

Abstract

Background: Hyperthermia has been included in the 2013 National Comprehensive Cancer Network (NCCN) guidelines as an option for the treatment of breast recurrences. The purpose of this article is to demonstrate the important role of hyperthermia as a therapeutic modality by presenting clinical trials on this subject carried out in the last decades. Materials and Methods: All relevant trials published since 1987 were retrieved from Medline and reviewed. Results: Results show that the addition of hyperthermia to radiotherapy and/or chemotherapy for the treatment of breast cancer enhances treatment response and can increase local control. Conclusion: Further studies are required to evaluate potential benefits of hyperthermia in the treatment of other kinds of superficial tumors.

Magnetic Hydrogel with Optimally Adaptive Functions for Breast Cancer Recurrence Prevention

“…The measured SAR values of the F‐MH are 371 (150 Oe) and 856 (220 Oe), respectively, almost 4.5‐ and 7.5‐fold greater than that of S‐MH, indicating the superiority of F‐MH with respect to induction heat (Figure c). Moreover, repeated or multiple hyperthermia treatments are normally adopted instead of one single treatment in clinical oncology 18c,30. Therefore, the temperature increase cycle was also measured, and the results have been presented in Figure d.…”

“…In addition, the intrinsic or acquired multidrug resistance resulting from individual variations is a major reason for the failure of these postoperative adjuvant therapeutic approaches . Recent advances in cancer medicine have revealed that physical hyperthermia combined with radiotherapy and/or chemotherapy can yield an optimized synergistic anticancer outcome 15c,18. In this context, the development of FVIO‐incorporated hydrogel with optimally adaptive functions ( Scheme ) and which can achieve efficient synergistic thermo‐chemotherapy may offer an alternative approach to address unmet clinical needs 1a,19…”

Hypofractionated re-irradiation of large-sized recurrent breast cancer with thermography-controlled, contact-free water-filtered infra-red-A hyperthermia: a retrospective study of 73 patients

“…Nevertheless, local control during lifetime is always the main therapeutic objective due to the extreme suffering caused by a visible disease requiring extensive care procedures and that may lead to social isolation. Recent reviews of randomised studies and retrospective analyses confirm the additional benefit of combined RT/HT for pre-irradiated recurrent breast cancer [21][22][23][24]. Inflammatory disease is reported to have a worse prognosis and significantly lower CR-rates [25,26].…”

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Metastasis from Breast Cancer: A Preliminary Report on 4 Cases

“…BC with invasive lobular carcinoma (ILC) frequently affects bones, retroperitoneum, peritoneum, gynaecological organs, and gastrointestinal (GI) tract [2][3]. The ve-year survival of BC has been increasing but the treatment of recurrent BC is a challenge [4][5]. Especially peritoneal metastasis from BC is a poorly de ned entity [6].…”