2002
DOI: 10.1002/cncr.10176
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Hyperthermic intraoperative intraperitoneal chemotherapy with cisplatin and doxorubicin in patients who undergo cytoreductive surgery for peritoneal carcinomatosis and sarcomatosis

Abstract: In complete control: The magnitude of current rectification in well‐defined supramolecular tunneling junctions can be controlled by changing the terminal functionality (red spheres) of dendrimers (gray spheres) immobilized on a supramolecular platform (see picture). Junctions containing biferrocene and ferrocene end groups showed larger rectification ratios than junctions containing adamantyl end groups.

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Cited by 78 publications
(26 citation statements)
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“…During HIPEC, peritoneal/plasma gradients of PLD averaged, respectively, ϳ600 or Ն1000 for C max or AUC (Ϫ5 min-1 h) . These values were comparable to or more than 1 order of magnitude higher than those calculated for intraperitoneally administered conventional doxorubicin (Ozols et al, 1982;Rossi et al, 2002;Sugarbaker et al, 2011); moreover, PLD plasma C max or AUC values always indicated that doxorubicin was safely entrapped inside the 2 PLD plasma AUC (Ϫ5 min-24 h) could not be determined accurately because of the limited number of plasma samples collected at 24 h. ) by a 1-h intravenous infusion in 250 ml of 5% glucose solution. In HIPEC patients, the first plasma samples were collected at Ϫ5 min (when PLD was injected for preperfusional equilibration in peritoneal cavity) and at 0 min (when the outflow line was opened for starting perfusion).…”
Section: Discussionmentioning
confidence: 74%
See 1 more Smart Citation
“…During HIPEC, peritoneal/plasma gradients of PLD averaged, respectively, ϳ600 or Ն1000 for C max or AUC (Ϫ5 min-1 h) . These values were comparable to or more than 1 order of magnitude higher than those calculated for intraperitoneally administered conventional doxorubicin (Ozols et al, 1982;Rossi et al, 2002;Sugarbaker et al, 2011); moreover, PLD plasma C max or AUC values always indicated that doxorubicin was safely entrapped inside the 2 PLD plasma AUC (Ϫ5 min-24 h) could not be determined accurately because of the limited number of plasma samples collected at 24 h. ) by a 1-h intravenous infusion in 250 ml of 5% glucose solution. In HIPEC patients, the first plasma samples were collected at Ϫ5 min (when PLD was injected for preperfusional equilibration in peritoneal cavity) and at 0 min (when the outflow line was opened for starting perfusion).…”
Section: Discussionmentioning
confidence: 74%
“…In fact, liposomes are big enough to show only limited partitioning across the regular microvasculature of heart and many other organs; on the other hand, liposomes are small enough to cross the "leaky" microvasculature of tumors and to eventually degrade for releasing free doxorubicin in close proximity to tumors cells (Minotti et al, 2004). Doxorubicin has long been used also in the settings of HIPEC (Ozols et al, 1982;Rossi et al, 2002;de Lima Vazquez et al, 2003;Deraco et al, 2011;Sugarbaker et al, 2011). A phase I study showed that HIPEC with pegylated liposomal doxorubicin (PLD) was also feasible, resulted in formation of very high doxorubicin peritoneal/ plasma gradients, and caused doxorubicin deposition in few samples of normal peritoneum that were examined at the end of the procedure; however, the study could not characterize how much doxorubicin was recovered as PLD or free drug.…”
Section: Introductionmentioning
confidence: 99%
“…[29] In the present study, economic costs were assessed according to the methodology of activity-based costing. [16] Unlike conventional costing accountancy in hospitals, which mainly focuses on services, the ABC approach focuses on activities, assuming that activities consume resources and services consume the activities. The ABC allows costs to be assessed thoroughly and correctly, since the resources used and activities performed are described precisely.…”
Section: A C C E P T E D Accepted Manuscriptmentioning
confidence: 99%
“…[21] The combination of cisplatin (45 mg/L) and doxorubicin (15 mg/L) was used in ten procedures, according to the results of a formal phase I study. [22] Two patients were treated with cisplatin alone (a total of 100 and 120 mg, respectively), one with cisplatin (25 mL/m 2 /L) plus mitomycin-C (3.3 mL/m 2 /L), and one with mitomycin-C (35 mg/m 2 ). Dose reduction up to 30% was applied to patients treated with prior systemic chemotherapy and/or extensive cytoreductive surgery.…”
Section: Operative Treatmentmentioning
confidence: 99%