Hyperthermy Increase the Phosphorylation of Deoxycytidine in the Membrane Phospholipid Precursors and Decrease its Incorporation into DNA

Hyperthermia is a rapidly developing treatment method in tumor-therapy. The classical effect is based on well-focused energy absorption targeting the malignant tissue. The treatment temperature has been considered as the main technical parameter. Unfortunately, the heat-shock protein (HSP) synthesis may considerably suppress the treatment's efficiency, adapting cells to survive the shock.Electro-hyperthermia heats up the targeted tissue by means of electricity, producing less HSP-synthesis in the cells than a usual hyperthermia process. The main idea is to keep the energy absorption in the extracellular liquid and, by heating it, increase the ion-mobility, intensify the metabolic rate of the cells, and destroy the cell membrane before the heat-shock activates the intra-cellular HSP mechanisms.

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“…5. The DNS replication can be blocked by means of heat effect slowing down the reproduction processes [28]. 6.…”

Section: Hyperthermia For Tumor Treatmentmentioning

confidence: 99%

Electro-hyperthermia: a New Paradigm in Cancer Therapy

Szász¹,

Szász²,

Szász³

2001

Deutsche Zeitschrift für Onkologie

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“…The ATP depletion makes a heavy ionicimbalance in cells [93]. Furthermore, the increased temperature can slow down or even arrest DNA replication, [94], [95].…”

Section: The Heating Paradigmmentioning

confidence: 99%

“…Higher tissue temperature stimulates the immune system [94] with observed increase in natural killer cell activity [96]. Moreover, the elevated temperature distributes tumorspecific antigens on the surface of various tumor cells [97] and assists in their secretion into the extracellular fluid [98], triggering the immune reactions against the malignant cell [94].…”

Section: The Heating Paradigmmentioning

confidence: 99%

Local Hyperthermia in Oncology – To Choose or not to Choose?

Szász¹,

Iluri²,

Szász³

2013

Hyperthermia

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“…The excretion of metabolic end products and the breakdown of environmental pollutants in the blood can be promoted; a stimulatory effect on the immune system is also described (39).…”

Section: Introductionmentioning

confidence: 99%

Multi-Modal Pain Therapy of Fibromyalgia Syndrome with Integration of Systemic Whole-Body Hyperthermia – Effects on Pain Intensity and Mental State: A Non-Randomised Controlled Study

Romeyke¹,

Stummer²

2014

Journal of Musculoskeletal Pain

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Objectives: This controlled study evaluates a multi-modal pain therapy for treating severe progressions of fibromyalgia [FMS] syndrome. The aim is to establish whether the use of multi-modal therapy with inclusion of whole-body hyperthermia represents a useful therapeutic addition to inpatient therapy of FMS syndrome at a high level of chronification. Methods: The study involved 130 patients who fulfilled the criteria of the American College of Rheumatology [ACR] for FMS and whose disease showed severe progression. One group of patients [HTG] received whole-body hyperthermia, while the control group [CG] did not. The main parameters of the study were pain intensity and the mental state of the patients. Further study parameters were the diagnoses additional to FMS syndrome and the therapy density of the treatment provided in the two groups. Results: The integration of whole-body hyperthermia into the multi-modal pain therapy showed superior pain reduction [p ¼ 0.023] and an improvement in the mental state of the patients [p ¼ 0.055]. In addition to the primary disease, the patients presented with an average of 6.7 accompanying diseases, primarily from major diagnostic categories 8 [diseases and disturbances of the musculoskeletal system and connective tissues], 19 [mental diseases and disturbances] and 10 [endocrine, nutritional and metabolic diseases]. Analysis of the therapy density of the inpatient multi-modal pain therapy revealed a close-meshed and high-frequency therapy. Conclusions: Multi-modal pain therapy was also found to be a highly effective therapy option in the case of severely progressive FMS syndrome. Extension of the multi-modal therapy setting to include whole-body hyperthermia can be considered as a useful and effective complement for pain relief and stabilisation of the mental state.

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Hyperthermy Increase the Phosphorylation of Deoxycytidine in the Membrane Phospholipid Precursors and Decrease its Incorporation into DNA

Cited by 6 publications

References 5 publications

Electro-hyperthermia: a New Paradigm in Cancer Therapy

Electro-hyperthermia: a New Paradigm in Cancer Therapy

Local Hyperthermia in Oncology – To Choose or not to Choose?

Multi-Modal Pain Therapy of Fibromyalgia Syndrome with Integration of Systemic Whole-Body Hyperthermia – Effects on Pain Intensity and Mental State: A Non-Randomised Controlled Study

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