Hyperthyroidism and Liver Dysfunction: A Review of a Common Comorbidity

Yorke, Ernest

doi:10.1177/11795514221074672

Cited by 33 publications

(33 citation statements)

References 29 publications

(51 reference statements)

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“…1 Impact of thyroid function on male and female reproductive system even symptomatic hypocortisolemia may be present [25]. In addition, prolonged hyperthyroidism leads to direct liver toxicity and hepatocyte anoxia with impaired liver function [26]. In patients with GD, LH secretion is increased compared to euthyroid patients [27].…”

Section: Impact On Spontaneous Conception Thyrotoxicosis Resultsmentioning

confidence: 99%

The role of thyroid function in female and male infertility: a narrative review

Mazzilli

Medenica

Tommaso

et al. 2022

J Endocrinol Invest

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Purpose We herein aimed to review the new insights into the impact of impaired thyroid function on male and female fertility, spacing from spontaneous pregnancy to ART, with the objective of providing an updated narrative revision of the literature. Methods This narrative review was performed for all available prospective, retrospective and review articles, published up to 2021 in PubMed. Data were extracted from the text and from the tables of the manuscript. Results Thyroid dysfunction is frequently associated with female infertility, whereas its link with male infertility is debated. Female wise, impaired function is detrimental to obstetric and fetal outcomes both in spontaneous pregnancies and in those achieved thanks to assisted reproduction technologies (ART). Furthermore, the reference range of TSH in natural pregnancy and ART procedures has recently become a matter of debate following recent reports in this field. On the other hand, the impact of thyroid function on the male reproductive system is less clear, although a possible role is suggested via modulation of Sertoli and Leydig cells function and spermatogenesis. Conclusion Thyroid function should be carefully monitored in both male and female, in couples seeking spontaneous pregnancy as well as ART, as treatment is generally immediate and likely to improve chances of success.

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Section: Impact On Spontaneous Conception Thyrotoxicosis Resultsmentioning

confidence: 99%

The role of thyroid function in female and male infertility: a narrative review

Mazzilli

Medenica

Tommaso

et al. 2022

J Endocrinol Invest

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“…(1) direct liver toxicity from exposure of excess thyroid hormones; (2) liver cell degeneration from accelerated decomposition of liver glycogen and protein; (3) congestive hepatopathy from thyrotoxic heart failure; (4) previous underlying liver disease; (5) toxicity and injury by antithyroid medications; (6) autoimmune-related liver injury. 5,6 Retrospective studies also reported that the risk factors of liver dysfunction were age, course of Graves' disesase, heart rate, weight of the thyroid gland, FT4 level, TR-antibodies, and TPO-antibodies. 7 Congestive hepatopathy is described as manifestations of chronic, passive congestion of the liver in the setting of heart failure or other cardiac defects that result in elevation of central venous pressure.…”

Section: Discussionmentioning

confidence: 99%

“…7 Congestive hepatopathy is described as manifestations of chronic, passive congestion of the liver in the setting of heart failure or other cardiac defects that result in elevation of central venous pressure. 6,8 Circulatory system disorders may cause hepatic dysfunction due to several mechanisms. First, right ventricular dysfunction increases preload or central venous pressure that can cause direct liver damage.…”

Section: Discussionmentioning

confidence: 99%

Congestive hepatopathy secondary to graves’ disease: a case report

Adrian¹,

Wirawan²

2022

Int J Adv Med

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Graves’ disease is a common cause of hyperthyroidism in iodine-sufficient parts of the world. Excessive thyroid hormone is known to have multiple effects on various organs, including the liver. We reported a case of 49-year old male patient with worsening jaundice, ascites, tremor, and palpitation, with previous history of uncontrolled Graves’ disease. Findings from examination reveals signs of congestive hepatopathy, such as positive hepatojugular reflux and dilated hepatic vein. Treatment options for hyperthyroidism in patients with liver dysfunction includes methimazole and radioactive iodine-131. Liver dysfunction in patients with thyrotoxicosis is commonly found in daily practice, but establishing the cause of liver dysfunction can be a challenge because of the multiple cause of liver injury in hyperthyroidism.

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“…The role of hyperthyroidism and liver dysfunction has been reported[ 23 ]. Hepatic biochemical abnormalities in untreated thyrotoxicosis patients is closed between [15%-76%], which may be explained by the conditions such as: direct liver cell injury, heart failure comorbidity, underlying autoimmune disorders a fortiori in hyperthyroidism, preexisting hepatic disease, and drugs combining antithyroid medicine.…”

Section: Liver Managementmentioning

confidence: 99%

“…A timely initiation of thionamides allows to normalize hepatic enzymes levels. Clinicians should suspect hyperthyroidism in patients with unexplained hepatic defect or unexplained Jaundice[ 23 ].…”

Section: Liver Managementmentioning

confidence: 99%

Current management of liver diseases and the role of multidisciplinary approach

Bouare¹

2022

World J Hepatol

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Liver is an organ having extremely diversified functions, ranging from metabolic and synthetic to detoxification of harmful chemicals. The multifunctionality of the liver in principle requires the multidisciplinary and pluralistic interventions for its management. Several studies have investigated liver function, dysfunction and clinic. This editorial work discusses new ideas, challenges and perspectives of current research regarding multidisciplinary and pluralistic management of liver diseases. In one hand the discussions have carried out on the involvement of extracellular vesicles, Na + /H + exchangers, severe acute respiratory syndrome coronavirus 2 and Epstein–Barr virus infections, Drug-induced liver injury, sepsis, pregnancy, and food supplements in hepatic disorders. In the other hand this study has discussed hepatocellular carcinoma algorithms and new biochemical and imaging experiments pertaining to liver diseases. Relevant articles with an impact index value "> 0" from reference citation analysis, which is an open multidisciplinary citation analysis database based on artificial intelligence technology, have served for the study’s argumentation. This work may be a useful tool for the clinical practice and research in managing and investigating liver disorders.

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Hyperthyroidism and Liver Dysfunction: A Review of a Common Comorbidity

Cited by 33 publications

References 29 publications

The role of thyroid function in female and male infertility: a narrative review

The role of thyroid function in female and male infertility: a narrative review

Congestive hepatopathy secondary to graves’ disease: a case report

Current management of liver diseases and the role of multidisciplinary approach

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