Hyperthyroidism induced by Graves’ disease reversibly affects skin microvascular reactivity

Bajuk, Nataša Bedernjak; Zaletel, Katja; Gaberšček, Simona; Lenasi, Helena

doi:10.3233/ch-141911

Cited by 6 publications

(1 citation statement)

References 35 publications

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“…Therefore, we decided to exclude patients with Hashimoto disease from the study. The effect of thyroid dysfunction on skin microcirculation has also been demonstrated by Pazos-Moura et al [86], Weiss et al [14], and Bajuk et al [87]. In addition, hormonal changes associated with puberty may affect skin microcirculation [88].…”

Section: Post Occlusive Reactive Hyperemiamentioning

confidence: 71%

The Impact of Disease Duration on Microcirculatory Dysfunction in Young Patients with Uncomplicated Type 1 Diabetes

Neubauer-Geryk,

Wielicka,

Hoffmann

et al. 2024

Biomedicines

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This study aimed to evaluate the earliest changes in the structure and function of the peripheral microcirculation using capillaroscopy and transcutaneous oxygen pressure measurement in children and adolescents with type 1 diabetes mellitus at baseline and during post-occlusive reactive hyperemia (PORH) in the function of diabetes duration. Sixty-seven patients with type 1 diabetes mellitus (T1D), aged 8 to 18 years, and twenty-eight age- and sex-matched healthy subjects were included in the analysis. Diabetic patients were divided into subgroups based on median disease duration. The subgroups differed in chronological age, lipid levels, and thyroid hormones. Capillaroscopy was performed twice: at baseline and then again after the PORH test. Transcutaneous oxygen pressure also was recorded under baseline conditions during and after the PORH test. Comparison of capillaroscopy and transcutaneous oxygen pressure parameters at rest and after the PORH showed no statistically significant difference between the subgroups. This remained true after adjusting for variables that differentiated the two subgroups. However, in the group of patients with long-standing diabetes, significant negative correlations were observed between the Coverage value after the PORH test and capillary reactivity with TcPO2_zero (biological zero). Significant positive correlations were also found between distance after the PORH test and TcPO2_zero. The results of our study indicate that in patients with a shorter duration of diabetes, the use of multiple tests provides a better characterization of the structure and function of microcirculation because the onset of dysfunction does not occur at the same time in all the tests.

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Section: Post Occlusive Reactive Hyperemiamentioning

confidence: 71%

The Impact of Disease Duration on Microcirculatory Dysfunction in Young Patients with Uncomplicated Type 1 Diabetes

Neubauer-Geryk,

Wielicka,

Hoffmann

et al. 2024

Biomedicines

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The Skin and Endocrine Disorders

Paus,

Ramot

2024

Rook's Textbook of Dermatology

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Endocrine disorders can exert major effects on the human skin, leading to different signs and symptoms, including skin dryness, hair loss or excessive hair growth, pruritus, pigmentary changes and hyperhidrosis. This chapter reviews these changes and provides a practical approach to patients with suspected underlying endocrinological disorders. The chapter also discusses the latest findings showing that the skin serves as a complex (neuro‐) endocrine organ by itself, and thus possesses important practical implications for future dermatological therapy.

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The impact of autoimmune thyroiditis on skin microcirculation in children with non-complicated type 1 diabetes mellitus

Hoffmann

Neubauer-Geryk

Wielicka

et al. 2019

Microvascular Research

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Hyperthyroidism induced by Graves’ disease reversibly affects skin microvascular reactivity

Abstract: Hyperthyroidism induced by GD reversibly affects skin microcirculation, presumably by increasing the vasodilator capacity. Potential involvement of TSAb might be implicated.

Cited by 6 publications

References 35 publications

The Impact of Disease Duration on Microcirculatory Dysfunction in Young Patients with Uncomplicated Type 1 Diabetes

The Impact of Disease Duration on Microcirculatory Dysfunction in Young Patients with Uncomplicated Type 1 Diabetes

The Skin and Endocrine Disorders

The impact of autoimmune thyroiditis on skin microcirculation in children with non-complicated type 1 diabetes mellitus

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