Hyperthyroidism Induced by Secondary Carcinoma in the Thyroid

Edmonds, C. J.; Thompson, B. D.

doi:10.1111/j.1365-2265.1978.tb02176.x

Cited by 23 publications

(11 citation statements)

References 14 publications

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“…Such a short clinical course is most compatible with destructive thyroiditis. Taking the findings of cytological and histopathological examinations together, we speculate that the tumor cells that metastasized to the thyroid from the lung adenocarcinoma grew so aggressively that thyroid fol- licles were destroyed, leading to transient thyrotoxicosis as a consequence of destructive thyroiditis, as reported previously (9)(10)(11)(12)(13)(14)(15)(16)(17). The excessive secretion of thyroid hormone was generally short-lived because iodine uptake was suppressed and hormonal stores would quickly become depleted.…”

Section: Discussionmentioning

confidence: 72%

“…Furthermore, only three cases are known to have developed transient thyrotoxicosis caused by massive metastasis of an extrathyroid tumor (Table 1), such as breast cancer (15,16) or pancreatic carcinoma (17). As shown in Table 1, on average, these thyrotoxic cases were young (47.6 6 13.2 years) and the duration from onset of thyrotoxicosis to death was short (7.8 months in metastatic cases, 56.5 days with anaplastic carcinoma).…”

Section: Discussionmentioning

confidence: 99%

“…The clinical course of most primary thyroid cancer patients is slowly progressive, but the prognosis for secondary thyroid cancer is poor. Furthermore, it is extremely rare that severe thyrotoxicosis is induced by thyroid cancer (9)(10)(11)(12)(13)(14)(15)(16)(17), which include only three reports of metastatic thyroid cancers of other origins causing thyrotoxicosis, namely, two of breast cancer (15,16) and one of pancreatic adenocarcinoma (17). Herein, we present the first case of metastatic thyroid cancer causing severe thyrotoxicosis because of aggressively destructive changes in thyroid follicles induced by invasion of tumor cells originating from a lung adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

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Severe Thyrotoxicosis Induced by Thyroid Metastasis of Lung Adenocarcinoma: A Case Report and Review of the Literature

Miyakawa

Sato²,

Hasegawa³

et al. 2001

Thyroid

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A 50-year-old woman who had undergone lung lobectomy because of lung adenocarcinoma presented with thyrotoxicosis, neck swelling, and cervical lymphadenopathy one month after the operation. The total serum triiodothyronine (T3) and thyroxine (T4) levels were markedly elevated to 514 ng/dL and 26.4 microg/dL, respectively, and serum thyrotropin (TSH) was suppressed to less than 0.005 microU/mL. Although the thyroid gland had been normal before surgery, chest computed tomography (CT) scan revealed a markedly enlarged thyroid gland only 1 month after surgery. 123I uptake for 24 hours was suppressed to 4% in the thyroid gland with no uptake elsewhere including the lung. Fine-needle aspiration cytology (FNAC) of the thyroid showed invasion of poorly differentiated adenocarcinoma cells, cytologically identical to the cells obtained from sputum and those infiltrating the resected sections of the lung adenocarcinoma. Immunohistochemical studies of resected lung tissues did not show positive staining for thyroglobulin, carcinoembryonic antigen (CEA), or surfactant protein A. Clinically, the thyrotoxicosis had spontaneously improved, followed by a hypothyroid state with shrinkage of the thyroid gland after chemotherapy. Despite repeated chemotherapy and the administration of thyroxine for hypothyroidism, the patient died of respiratory failure 9 months after the onset of thyrotoxicosis. From these findings and the clinical course, thyroid metastasis, developing subacutely from lung adenocarcinoma, was diagnosed. We speculate that aggressive invasion of tumor cells into the thyroid gland resulted in highly destructive thyrotoxicosis.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Severe Thyrotoxicosis Induced by Thyroid Metastasis of Lung Adenocarcinoma: A Case Report and Review of the Literature

Miyakawa

Sato²,

Hasegawa³

et al. 2001

Thyroid

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“…The incidence ranges from 3.9% to 24.2% based on autopsy studies [2,3], however, the clinically demonstrated incidence is only between 0.05% and 3.1% [4][5][6]. The primary cancers in these cases are commonly renal cell carcinoma, lung cancer and breast cancer [4,[7][8][9][10]. Metastatic thyroid tumors are often accompanied with synchronous metastatic lesions to other organs [11].…”

Section: Introductionmentioning

confidence: 97%

Isolated metastasis of lung cancer to the thyroid gland

et al. 2007

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“…Only 12 cases of metastasis from colon cancer to the thyroid have been reported since 1936 [4][5][6][7]. Currently there are only 5 cases of thyroid dysfunction caused by metastatic cancer infiltration [8][9][10][11][12]. Most of the manifestations were thyrotoxicosis followed by destruction.…”

mentioning

confidence: 99%

Severe Hypothyroidism Induced by Thyroid Metastasis of Colon Adenocarcinoma: A Case Report and Review of the Literature

et al. 2006

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Abstract. An 85-year-old man who had undergone a right hemicolectomy for colon cancer presented with severe hypothyroidism and hoarseness 21 months after the operation. The serum thyrotropin (TSH) was markedly elevated to 118.14 µIU/mL and serum free thyroxine (fT4) level was markedly suppressed to 0.34 ng/dL. Symptoms of hoarseness and neck swelling were already evident 4 months prior at which time tests for normal thyroid function were performed. The patient was referred due to aggravated pain on his diffusely enlarged hard goiter. An enlarged thyroid with some calcification was noticed in the neck ultrasonography with multiple cervical lymphadenopathies. Core biopsy of the thyroid gland showed invasion of poorly differentiated adenocarcinoma cells. Immunohistochemical studies showed positive staining only for carcinoembryonic antigen (CEA). There were multiple lung parenchymal nodules and adrenal masses at the time of evaluation. The patient was started on palliative chemotherapy with thyroid hormone replacement and gradually became euthyroid. From these findings and the clinical observations, thyroid metastasis with hypothyroidism developing acutely from metastatic colon adenocarcinoma was diagnosed.

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Hyperthyroidism Induced by Secondary Carcinoma in the Thyroid

Cited by 23 publications

References 14 publications

Severe Thyrotoxicosis Induced by Thyroid Metastasis of Lung Adenocarcinoma: A Case Report and Review of the Literature

Severe Thyrotoxicosis Induced by Thyroid Metastasis of Lung Adenocarcinoma: A Case Report and Review of the Literature

Isolated metastasis of lung cancer to the thyroid gland

Severe Hypothyroidism Induced by Thyroid Metastasis of Colon Adenocarcinoma: A Case Report and Review of the Literature

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