Hypertonic/Hyperoncotic Resuscitation After Intestinal Superior Mesenteric Artery Occlusion: Early Effects on Circulation and Intestinal Reperfusion

Jonas, J.; Heimann, Axel; Strecker, Ulrich; Kempski, Oliver

doi:10.1097/00024382-200014010-00005

Cited by 34 publications

(14 citation statements)

References 22 publications

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“…In line with this, Beuk et al described a negative correlation between submucosal capillary perfusion and leukocyte adherence in submucosal venules and an reaction of the intestinal microcirculation with normalization of intramural pHi and lactate. This indicates that the implementation of a steep osmotic gradient across vascular and cell membranes causes a fluid shift from interstitial towards the intravascular space, finally improving rheology and blood flow conditions [50].…”

Section: Mechanisms Of Acute Intestinal I/r Injurymentioning

confidence: 99%

Intestinal ischemia/reperfusion: microcirculatory pathology and functional consequences

Vollmar

Menger

2010

Langenbecks Arch Surg

232

153

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Section: Mechanisms Of Acute Intestinal I/r Injurymentioning

confidence: 99%

Intestinal ischemia/reperfusion: microcirculatory pathology and functional consequences

Vollmar

Menger

2010

Langenbecks Arch Surg

232

153

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“…The protection of tissues subjected to I/R, as well as those who suffer the remote consequences, has been widely investigated. Some experimental protocols have shown benefits in using hypertonic saline (HS) associated to the anti-inflammatory properties of the nonspecific phosphodiesterase inhibitor pentoxifylline (PTX) on animals subjected to shock 1,2 .…”

Section: Introductionmentioning

confidence: 99%

Pentoxifylline associated to hypertonic saline solution attenuates inflammatory process and apoptosis after intestinal ischemia/reperfusion in rats

Marques

Rasslan²,

Belon³

et al. 2014

Acta Cir. Bras.

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PURPOSE:To evaluate intestinal inflammatory and apoptotic processes after intestinal ischemia/reperfusion injury, modulated by pentoxifylline and hypertonic saline. METHODS:It was allocated into four groups (n=6), 24 male Wistar rats (200 to 250g) and submitted to intestinal ischemia for 40 min and reperfusion for 80 min: IR (did not receive any treatment); HS group (Hypertonic Saline, 4ml/kg-IV); PTX group (Pentoxifylline, 30mg/ kg-IV); HS+PTX group (Hypertonic Saline and Pentoxifylline). All animals were heparinized (100U/kg). At the end of reperfusion, ileal fragments were removed and stained on hematoxylin-eosin and histochemical studies for COX-2, Bcl-2 and cleaved caspase-3. RESULTS:The values of sO 2 were higher on treated groups at 40 minutes of reperfusion (p=0.0081) and 80 minutes of reperfusion (p=0.0072). Serum lactate values were lower on treated groups after 40 minutes of reperfusion (p=0.0003) and 80 minutes of reperfusion (p=0.0098). Morphologic tissue injuries showed higher grades on IR group versus other groups: HS (p=0.0006), PTX (p=0.0433) and HS+PTX (p=0.0040). The histochemical study showed lesser expression of COX-2 (p=0.0015) and Bcl-2 (p=0.0012) on HS+PTX group. A lower expression of cleaved caspase-3 was demonstrated in PTX (p=0.0090; PTXvsIR). CONCLUSION:The combined use of pentoxifylline and hypertonic saline offers best results on inflammatory and apoptotic inhibitory aspects after intestinal ischemia/reperfusion.

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“…These effects in combination with an increase of cardiac output (2,4,5) and a decrease of the perivascular resistance contribute to the microcirculatory and metabolic improvement, mentioned as the most important mechanisms of small volume resuscitation after shock (6,7,10). Beneficial effects on the microcirculation have been reported in kidney, heart, liver (4), and small intestine (1,11).…”

mentioning

confidence: 99%

Effects of hypertonic/hyperoncotic treatment after rat cortical vein occlusion*

Heimann

Takeshima

Alessandri

et al. 2003

Critical Care Medicine

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Hypertonic/Hyperoncotic Resuscitation After Intestinal Superior Mesenteric Artery Occlusion: Early Effects on Circulation and Intestinal Reperfusion

Cited by 34 publications

References 22 publications

Intestinal ischemia/reperfusion: microcirculatory pathology and functional consequences

Intestinal ischemia/reperfusion: microcirculatory pathology and functional consequences

Pentoxifylline associated to hypertonic saline solution attenuates inflammatory process and apoptosis after intestinal ischemia/reperfusion in rats

Effects of hypertonic/hyperoncotic treatment after rat cortical vein occlusion*

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