Hypertonic saline enhances host defense to bacterial challenge by augmenting Toll-like receptors*

Chen, Lee Wei; Huang, Hau-Lun; Lee, I-Te; Hsu, Chen-Pin; Lu, Pei‐Jung

doi:10.1097/01.ccm.0000218810.66485.01

Cited by 31 publications

(15 citation statements)

References 33 publications

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“…Chen et al [25] showed that hypertonic resuscitation in a burned mouse model decreased bacterial translocation by increasing phagocytic activity of peritoneal and systemic inflammatory cells. This report may not yet be applicable at the bedside, but it should serve to remind clinicians that the effects of our interventions are not all apparent on rounds or in the clinical laboratory.…”

Section: Infectionmentioning

confidence: 99%

Advances in burn care

Namias¹

2007

Current Opinion in Critical Care

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Section: Infectionmentioning

confidence: 99%

Advances in burn care

Namias¹

2007

Current Opinion in Critical Care

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“…Chen et al [114] evaluated the effects of HS on the thermal injury in mice with a particular emphasis on in vitro and in vivo host defense to bacterial challenge. This study reported that HS treatment decreased bacterial translocation, enhanced phagocytosis and clearance of bacteria as well as increased the expressions of TLR2, TLR4, CXCR2, pp38, and p44/42 in the peritoneal cells and neutrophils.…”

Section: Molecular and Cellular Effects Of Hsmentioning

confidence: 99%

The use of Hypertonic Saline in the Treatment of Post-Traumatic Cerebral Edema: A Review

Catrambone

Prestigiacomo

et al. 2007

Eur J Trauma Emerg Surg

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Effective methods for treating cerebral edema have recently become a matter of both extensive research and significant debate within the neurosurgery and trauma surgery communities. The pathophysiologic progression and outcome of different forms of cerebral edema associated with traumatic brain injury have yet to be fully elucidated. There are heterogeneous factors influencing the onset and progress of post-traumatic cerebral edema, including the magnitude and type of head injury, age, co-morbid conditions of the patient, the critical window for therapeutic intervention and the presence of secondary insults including hypoxia, hypotension, hypo/hyperthermia, degree of raised intracranial pressure (ICP), and disruption of blood brain barrier (BBB) integrity. Although numerous studies have been designed to improve our understanding of the etiology of post-traumatic cerebral edema, therapeutic interventions have traditionally been focused on minimizing secondary insults especially raised ICP and improving cerebral perfusion pressure. More recently, fluid resuscitation strategies using hyperosmolar agents such as pentastarch and hypertonic saline (HS) have achieved some success. HS treatment is of particular interest due to its apparent advantageous action over other types of hyper-osmotic solutions in both clinical and laboratory studies. In this review, we provide a summary of recent literature concerning the pathogenesis and mechanisms involved in the various types of cerebral edema, and the possible mechanisms of action of HS for the treatment cerebral edema.

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“…Recently it has been shown in a mouse model post thermal injury that hypertonic saline enhances host defense to bacterial challenge by augmenting TLRs [156] . Nebulised hypertonic saline, although a different mode of delivery and for a different purpose, may in fact work in a similar way.…”

Section: Mucolytic Therapiesmentioning

confidence: 99%