Hypertrichosis due to diazoxide

Burton, J.L.; Schutt, W. H.; Caldwell, I.W.

doi:10.1111/j.1365-2133.1975.tb05123.x

Cited by 63 publications

(11 citation statements)

References 15 publications

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“…Diazoxide is another antihypertensive potassium channel opener which increases blood flow and is reputed to increase hair growth. 14,15 Laser Doppler velocimetry studies showed an increase in cutaneous blood flow after applying 1%, 3%, and 5% minoxidil solutions to the scalps of 16 balding men. 16 All three groups showed increases compared to a control group, and the 5% group showed the greatest increase.…”

Section: Mechanism Of Actionmentioning

confidence: 98%

Medical treatments for male and female pattern hair loss

Rogers¹,

Avram²

2008

Journal of the American Academy of Dermatology

241

160

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Section: Mechanism Of Actionmentioning

confidence: 98%

Medical treatments for male and female pattern hair loss

Rogers¹,

Avram²

2008

Journal of the American Academy of Dermatology

241

160

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“…Hypertrichosis is seen in less than 1 % of adults receiving diazoxide because of hypertension (Burton et al 1975). It is much more frequent and severe in children than in adults, occurring in almost 100% of children receiving diazoxide for idiopathic hypoglycaemia.…”

Section: Diazoxidementioning

confidence: 99%

Drug-Induced Hair Loss and Hair Growth

et al. 1994

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A large number of drugs may interfere with the hair cycle and produce hair loss. Drugs may affect anagen follicles through 2 main different modalities: (i) by inducing an abrupt cessation of mitotic activity in rapidly dividing hair matrix cells (anagen effluvium) or (ii) by precipitating the follicles into premature rest (telogen effluvium). In anagen effluvium, hair loss usually occurs within days to weeks of drug administration, whereas in telogen effluvium, hair loss becomes evident 2 to 4 months after starting treatment. Anagen effluvium is a prominent adverse effect of antineoplastic agents, which cause acute damage of rapidly dividing hair matrix cells. Telogen effluvium may be a consequence of a large number of drugs including anticoagulants, retinol (vitamin A) and its derivatives, interferons and antihyperlipidaemic drugs. Drug-induced hair loss is usually reversible after interruption of treatment. The prevalence and severity of alopecia depend on the drug as well as on individual predisposition. Some drugs produce hair loss in most patients receiving appropriate dosages while other drugs are only occasionally responsible for hair abnormalities. Both hirsutism and hypertrichosis may be associated with drug administration. Drugs most commonly responsible for the development of hirsutism include testosterone, danazol, corticotrophin (ACTH), metyrapone, anabolic steroids and glucocorticoids. Hypertrichosis is a common adverse effect of cyclosporin, minoxidil and diazoxide.

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“…To date, there is no experience with long‐term and high‐dose DZX treatment for obesity. It is not an option for women because DZX may cause hypertrichosis; in most men, this will not be an important issue [16]. Short‐term DZX–mediated insulin suppression in men has been evaluated in a 1‐week dose–response study designed to determine the optimal dose for the treatment of obesity [17].…”

Section: Introductionmentioning

confidence: 99%