Hypertriglyceridaemia and Hypercoagulability

Simpson, H.C.R.; Meade, T W; Stirling, Yvonne; Mann, Jim; Chakrabarti, Ranjan; Woolf, Linda

doi:10.1016/s0140-6736(83)91849-4

Cited by 293 publications

(110 citation statements)

References 22 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…22 Our results suggest that the partial substitution of modest amounts of marine oils for other fats in the diet through the consumption of seafood or fish-oil supplements is an efficient method of lowering plasma triglyceride levels in patients with primary hypertriglyceridemia associated with high rates of VLDL synthesis. In addition to reducing plasma triglyceride concentrations, such a change may also have a beneficial effect on the hemostatic function, 30 " 35 which has recently been reported 36 to be hyperactive in hypertriglyceridemia.…”

Section: Discussionmentioning

confidence: 99%

Triglyceride-lowering effect of marine polyunsaturates in patients with hypertriglyceridemia.

Sanders¹,

Sullivan²,

Reeve³

et al. 1985

Arteriosclerosis

194

View full text Add to dashboard Cite

Twenty male patients with primary hypertriglyceridemia were treated for 4 weeks with daily supplements (15 g) of oil, which provided approximately 6 g of polyunsaturated fatty acid (PUFA) either of fish or of vegetable origin. Total plasma cholesterol concentrations were unaffected, but both types of supplement increased high density lipoprotein-3 (HDL 3 ) cholesterol concentrations. The fish, but not the vegetable, oil supplement led to a decrease in plasma triglyceride concentrations. Very low density lipoprotein (VLDL), fatty acid composition, and VLDL triglyceride kinetics were subsequently studied in five patients (four male, one female) before and after 4 weeks of therapy with 15 g of the same fish oil. The fish oil led to increases in the proportion of eicosapentaenoic acid in both the VLDL triglyceride and phospholipid fractions, but the increase was greater in the latter. In contrast, the proportion of docosahexanoic acid was increased only in the VLDL triglycerides. The decrease in plasma triglyceride concentrations that occurred with fish-oil therapy was accompanied by a reduction in the absolute catabolic rate of VLDL triglyceride, implying a concomitant change in synthetic rate; the fractional catabolic rate of VLDL triglyceride was unaltered. It is suggested that polyunsaturated fatty acids of marine origin may be therapeutically useful for hypertriglyceridemia. (Arteriosclerosis 5:459-465, September/October 1985)

show abstract

Section: Discussionmentioning

confidence: 99%

Triglyceride-lowering effect of marine polyunsaturates in patients with hypertriglyceridemia.

Sanders¹,

Sullivan²,

Reeve³

et al. 1985

Arteriosclerosis

194

View full text Add to dashboard Cite

show abstract

“…Age, 17,32 obesity, 19,32,33 dietary fat intake, 34,35 lipids, 16,19,30,33,36 menopause, and oral contraceptive use in women 30,33 have all been described to influence factor VII levels. In our study, triglyceride levels, female sex, BMI, total cholesterol, estrogen replacement therapy, HDL cholesterol, …”

Section: The Arg/gln Polymorphism Traditional Risk Factors and Factmentioning

confidence: 99%

Factor VII Gene Polymorphism, Factor VII Levels, and Prevalent Cardiovascular Disease

Feng

Tofler

Larson

et al. 2000

ATVB

View full text Add to dashboard Cite

Abstract-Elevated factor VII levels have been associated with increased cardiovascular risk in some studies. The arginine/glutamine (Arg/Gln) polymorphism of the factor VII gene has been previously shown to modify factor VII levels. However, the presence of a gene/environment interaction on factor VII levels or a link with cardiovascular disease (CVD) remains uncertain. We studied subjects from the Framingham Heart Study to determine (1) the extent to which this genetic polymorphism affects factor VII levels; (2) whether interactions exist between this polymorphism and environmental factors on factor VII levels; and (3) the association between the polymorphism and CVD. Genotype data and factor VII antigen levels were available in 1816 subjects. Factor VII levels differed significantly among genotypes in an additive fashion: Gln homozygous, 82.7Ϯ2.5%; heterozygous, 92.2Ϯ0.7%; and Arg homozygous, 100.5Ϯ0.4% (PϽ0.0001). The polymorphism was the strongest, single predictor of factor VII levels, explaining 7.7% of the total variance of factor VII levels, whereas other traditional risk factors combined explained an additional 11.5% of the variance. There was an interaction (Pϭ0.02) between the genotype and total cholesterol on factor VII levels, such that the correlation coefficient and slope (factor VII level/total cholesterol) were greatest in Gln/Gln subjects. Among 3204 subjects characterized for genotype and CVD, there was no significant relationship between the genotype and CVD (Pϭ0.12). In the Framingham Heart Study, the Arg/Gln polymorphism was significantly associated with factor VII antigen levels. The strength of the association suggests that genetic variation plays an important role in determining factor VII levels. However, despite being associated with factor VII levels, the Arg/Gln polymorphism was not associated with prevalent CVD. (Arterioscler Thromb Vasc Biol. 2000;20:593-600.)

show abstract

“…37 -38 Disadvantages include, at least transiently, an increase in plasma triglyceride concentrations and a concomitant decrease in HDL-C concentrations. 3 -4 -39 - 43 An increase in plasma triglyceride concentration can be avoided by small incremental increases as opposed to one big increase in the carbohydrate content of the diet. 44 The third alternative when reducing the fat content of the diet is to not replace it with anything.…”

mentioning

confidence: 99%

Short-term consumption of a low-fat diet beneficially affects plasma lipid concentrations only when accompanied by weight loss. Hypercholesterolemia, low-fat diet, and plasma lipids.

Lichtenstein

Ausman

Carrasco

et al. 1994

Arterioscler Thromb

View full text Add to dashboard Cite

Study subjects (6 women and 5 men) over the age of 40 years with fasting low-density lipoprotein cholesterol concentrations >130 mg/dL were studied during three 5-week diet phases and one 10-week phase: baseline (36% fat: 13% saturated fatty acids [SFA], 12% monounsarurated fatty acids [MUFA], 8% polyunsaturated fatty acids [PUFA], and 128 mg cholesterol/1000 kcal); reduced fat (29% fat: 7% SFA 9% MUFA 11% PUFA and 85 mg cholesterol/1000 kcal); and two low fat (15% fat: 5% SFA 5% MUFA 3% PUFA and 73 mg cholesterol/1000 kcal). Body weight was maintained during the first three 5-week phases (baseline, reduced fat, and low fat [-• energy]) and decreased during the last 10-week phase when the low-fat diet was provided such that the subjects determined, in part, their caloric intake (low fat [I energy]). Mean body weight declined by 0.62±0.47 kg/wk during the first 5 weeks and 0.43±0.43 kg/wk during the second 5 weeks of the 10-week low-fat (I energy) period. Relative to the baseline diet, plasma cholesterol concentrations decreased from 226±33 to 195 + 19 (-13%), 208±22 (-7%), and 190±19 (-15%) mg/dL when the subjects consumed the reduced-fat, low-fat (-» energy), and low-fat (j energy) diets, respectively. Low-density lipoprotein cholesterol concentrations decreased T here is general agreement that the fat content of the average diet should be reduced. 1 Reference to such recommendations is not without historical basis. 2 Additionally, the general consensus appears to be that cutting the saturated fat content of the diet imparts the most benefit with respect to lowering plasma cholesterol levels. 35 The optimal level to which the total and saturated fat content in the diet should be reduced is far more controversial. 610 Current National Cholesterol Education Program (NCEP) dietary recommendations concerning fat are relatively broad: total fat intake s30% and saturated fat intake £10% of calories (step 1) or <.!% (step 2) of calories, depending on initial plasma lipid levels and initial response. 1 Expected reductions in plasma lipid concentrations include declines in both low-density O 1994 American Heart Association, Inc.from 158±28 to 128±16 (-18%), 134±17 (-14%), and 119+15 (-23%) mg/dL when the subjects consumed the reduced-fat, low-fat (-» energy), and low-fat (| energy) diets, respectivery. High-density lipoprotein cholesterol concentrations decreased from 48±11 to 42±9 (-10%), 35±7 (-25%), and 38±8 (-18%) mg/dL when the subjects consumed the reduced-fat, low-fat (-» energy), and low-fat (i energy) diets, respectively. Triglyceride concentrations increased from 110+32 to 115±31 (8%), 188±76 (75%), and 130±32 (22%) mg/dL when the subjects consumed the reduced-fat, low-fat (-» energy), and low-fat (j energy) diets, respectively. Maximal changes in plasma lipid concentrations were observed after the first 5 weeks of the low-fat (| energy) diet phase despite continued weight loss throughout the entire 10-week diet period. These data suggest that very-low-fat diets (15% of calories) beneficially affect...

show abstract

Hypertriglyceridaemia and Hypercoagulability

Cited by 293 publications

References 22 publications

Triglyceride-lowering effect of marine polyunsaturates in patients with hypertriglyceridemia.

Triglyceride-lowering effect of marine polyunsaturates in patients with hypertriglyceridemia.

Factor VII Gene Polymorphism, Factor VII Levels, and Prevalent Cardiovascular Disease

Short-term consumption of a low-fat diet beneficially affects plasma lipid concentrations only when accompanied by weight loss. Hypercholesterolemia, low-fat diet, and plasma lipids.

Contact Info

Product

Resources

About