Hypertriglyceridemia and atherosclerosis

Jia, Peng; Luo, Fei; Ruan, Guiyun; Ran, Pixin; Li, Xiangping

doi:10.1186/s12944-017-0625-0

Cited by 205 publications

(163 citation statements)

References 85 publications

(107 reference statements)

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“…Age is known as the dominant cardiovascular disease (CVD) risk factor due to dyslipidaemia in both men and women older than 65 years, as compared to younger individuals [16]. Further, elevated triglycerides (Tg) and very low density level (VLDL) cholesterol levels have been associated with subclinical atherosclerosis and dubbed as independent risk factors for CVD [17]. Several large studies suggest that hypertriglyceridemia is related to increased levels of remnant lipoproteins in promoting atherogenesis [18], [19].…”

Section: Introductionmentioning

confidence: 99%

Gut Mycobiome Dysbiosis is Linked to Hypertriglyceridemia Among Home Dwelling Elderly Danes

Ahmad

Castro‐Mejía

Krych

et al. 2020

Preprint

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24 25 26 Email addresses: 27 HFA fauzanahmad@ump.edu.my 28 JLC jcame@food.ku.dk 29 ŁK krych@food.ku.dk 30 BK bzo@food.ku.dk 31 WK wk@envs.au.dk 32 RLB r.bechshoeft@gmail.com 33 SR s.reitelseder@gmail.com 34 GWH grith.westergaard.hoejfeldt.01@regionh.dk 35 SBE se@food.ku.dk 36 LH l.holm@bham.ac.uk 37 KF karoline.faust@kuleuven.be 38 DSN dn@food.ku.dk 39 40 41 42 43 44 45 ABSTRACT 46 Gut microbial dysbiosis have been in the etiology of a number of diseases, yet 47 the presence of fungal communities and their possible association with host health are 48 little understood. This study attempts to identify gut microbial fungal associations 49 with the progression of atherogenic dyslipidemia in a population of older adults by 50 investigating the interplay between dietary intake, gut mycobiome composition, 51 plasma and fecal metabolome and anthropometric/body-composition measurements of 52 100 Danes aged 65 to 81 (69.57  3.64) years. The gut mycobiome composition were 53 determined by high-throughput sequencing of internal transcribed spacer (ITS2) gene 54 amplicons, while the plasma and fecal metabolome was determined by GC-TOF-MS. 55 The gut microbiome of the subjects investigated is home to three main eukaryotic 56 phyla, namely Ascomycota, Basidiomycota and Zygomycota, with genera 57 Penicillium, Candida, and Aspergillus being particularly common. 58 Hypertriglyceridemia was associated with fewer observed fungal species, and Bray-59 Curtis dissimilarity matrix-based analysis showed significant (P<0.05) clustering 60 according to fasting levels of circulating plasma triglycerides (Tg) and very low-61 density lipoprotein (VLDL) cholesterol fasting levels, respectively. Interestingly, 62 neither hypertriglyceridemia nor elevated VLDL levels were reflected in the 63 prokaryotic component of the gut microbiome as determined by 16S rRNA gene 64 amplicon sequencing. Higher levels of Tg and VLDL cholesterol significantly 65 associates with increased relative abundance of genus Penicillium, possibly mediated 66 by a higher dietary fat intake (ANOVA, P<0.05), and Aspergillus and Guehomyces 67 were positively associated with SCFAs groups. Collectively, these findings suggest 68 that in older adults' gut mycobiome dysbiosis is associated with hypertriglyceridemia, 69 a known risk factor for development of cardiovascular disease. 70 71 Keywords: older-adults, hypertriglyceridemia, dysbiosis, gut mycobiome, host 72 metabolome, triglyceride, VLDL and dietary fat intake 73 74 75 93 dyslipidaemia in both men and women older than 65 years, as compared to younger 94 individuals [16]. Further, elevated triglycerides (Tg) and very low density level 95 (VLDL) cholesterol levels have been associated with subclinical atherosclerosis and 96 dubbed as independent risk factors for CVD [17]. Several large studies suggest that 97 hypertriglyceridemia is related to increased levels of remnant lipoproteins in 98 promoting atherogenesis [18], [19]. The possible mechanisms for this association 99 include excessive free fatty acid release, product...

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Section: Introductionmentioning

confidence: 99%

Gut Mycobiome Dysbiosis is Linked to Hypertriglyceridemia Among Home Dwelling Elderly Danes

Ahmad

Castro‐Mejía

Krych

et al. 2020

Preprint

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“…Atherosclerosis is a complicated process involving many mechanisms, such as in ammation, lipid accumulation, and insulin resistance. Chronic in ammation plays a key role in atherosclerosis, and lipoprotein cholesterol accumulation and insulin resistance promote in ammation and the formation of atherosclerotic plaques [13][14][15] . In this study, the main nding was that the AIP, TyG index and MLR were independent risk factors for subclinical CAD.…”

Section: Discussionmentioning

confidence: 99%

Atherogenic Index of Plasma, Triglyceride-Glucose Index and Monocyte-to-Lymphocyte Ratio for Predicting Subclinical Coronary Artery Disease

Fan

Chen

et al. 2020

Preprint

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Background: The atherogenic index of plasma (AIP), triglyceride-glucose (TyG) index, and monocyte-to-lymphocyte ratio (MLR) are strongly associated with atherogenesis of the coronary artery. This study aimed to investigate the association of the AIP, TyG index, and MLR with subclinical coronary artery disease (CAD) and evaluate their ability to predict subclinical CAD.Methods: A total of 697 asymptomatic patients were enrolled in this study and assigned to the subclinical CAD group (n=332) and control group (n=365). The clinical data, coronary artery calcification score, and calculated AIP, TyG index, and MLR were collected by graduate students in the cardiology division. Multivariate logistic regression models were set up to assess the risk factors for subclinical CAD.Results: The AIP, TyG index and MLR values were higher in the subclinical CAD group than in the control group (all P<0.05). In addition to the classic independent clinical risk factors, increased AIP, TyG index and MLR values were all independent risk factors for subclinical CAD (all P<0.05). The AUCs were higher after combining clinical risk factors than the AIP, TyG index, or MLR alone (all P<0.05).Conclusions: The AIP, TyG index and MLR are independent risk factors for subclinical CAD, which can be useful for improving the diagnosis and prevention of CAD.

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“…For the past few years, the research on ectopic fat obesity has gradually increased, it has been found that ectopic fat obesity is an important risk factor for a variety of cardiovascular diseases and type 2 diabetes [7,[15][16][17], while the status of TG has been gradually improved in the cardiovascular and endocrine fields [11,[19][20][21], but there is no clear standard for the evaluation of ectopic fat obesity at present. In this study, after adjusting covariates, it is confirmed that TG is related to ectopic fat obesity (OR:1.55,95%CI:1.41-1.69,p<0.00001), and the risk of ectopic fat obesity in the higher TG group (≥1.118mmol/l) was 3.16 times higher (OR:3.16,95%CI:2.45-4.07,p<0.00001, P for trend<0.00001) than that in the lower TG group (≤0.497mmol/l).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have reported that there is a close relationship between ectopic fat obesity and dyslipidemia, diabetes and cardiovascular disease [7,[15][16][17]. Søndergaard E et al have pointed out that the storage of Triglycerides (TG) in different tissues may lead to ectopic fat accumulation and contribute to the progression of type 2 diabetes [18], in the cardiovascular field, the relationship between TG and a variety of cardiovascular diseases has a similar positive correlation [19][20][21]. At present, there is little research data on the relationship between TG and the risk of ectopic fat obesity, in the guidelines, there are no clear instructions of the treatment of ectopic fat obesity for the management of blood lipids.…”

Section: Introductionmentioning

confidence: 99%

The Connection Between Triglycerides and Ectopic Fat Obesity: An Inverted U-Shaped Curve

Zou

Meng

Sheng

et al. 2020

Preprint

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Background: Ectopic fat obesity and Triglycerides are risk factors for diabetes and multiple cardiovascular diseases, but the data on the relationship between Triglycerides and the risk of ectopic fat obesity are limited. The purpose of this study is to explore the connection between Triglycerides and ectopic fat obesity.Methods: This is a cross-sectional study, we retrospectively analyzed 15464 adult participants recruited by Murakami Memorial Hospital from 2004-2015(8430 men and 7034 women, average age 43.71±8.9), to performed the relationship between Triglycerides and ectopic fat obesity, we divided all patients into 4 groups according to the quartile of Triglycerides. Logistic regression model was used to analyze the relationship between Triglycerides and the risk of ectopic fat obesity, and the generalized additive model was used to identify the nonlinear relationship.Results: In the study population, the prevalence of ectopic fat obesity was 17.73%, and gradually increased in the quartile of Triglycerides (2.86,7.89,18.25 and 41.22% respectively, P < 0.001).After adjusting other covariables, Triglycerides was positively correlated with the risk of ectopic fat obesity (OR:1.55,95%CI:1.41-1.69, p<0.00001). Then we carried out smooth curve fitting and found that there was an inverted U-shaped curve relationship between Triglycerides and ectopic fat obesity, even if those adjusted covariables were removed from the model, the result remained unchanged, and the inflection point of the curve was 3.98. On the left side of the inflection point, Triglycerides was positively correlated with the risk of ectopic fat obesity(OR:1.784,95%CI:1.611-1.975,p<0.0001), while on the right side of the inflection point, there was a negative correlation (OR:0.519,95%CI:0.333-0.810,p=0.0039).Conclusions: Our research shows that there is a significant correlation between Triglycerides and ectopic fat obesity, this relation is not a simple linear relationship, but it was an inverted U-shaped curve relationship.

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Hypertriglyceridemia and atherosclerosis

Cited by 205 publications

References 85 publications

Gut Mycobiome Dysbiosis is Linked to Hypertriglyceridemia Among Home Dwelling Elderly Danes

Gut Mycobiome Dysbiosis is Linked to Hypertriglyceridemia Among Home Dwelling Elderly Danes

Atherogenic Index of Plasma, Triglyceride-Glucose Index and Monocyte-to-Lymphocyte Ratio for Predicting Subclinical Coronary Artery Disease

The Connection Between Triglycerides and Ectopic Fat Obesity: An Inverted U-Shaped Curve

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