Hypertriglyceridemia and hypoalphalipoproteinemia in azoospermic and oligospermic young men: Relationships of endogenous testosterone to triglyceride and high density lipoprotein cholesterol metabolism

Mendoza, Soaira; Osuna, Alfonso J. García; Zerpa, A.; Gartside, Peter S.; Glueck, Charles J.

doi:10.1016/0026-0495(81)90184-0

Cited by 53 publications

(23 citation statements)

References 15 publications

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Section: Discussionmentioning

confidence: 99%

“…The decrement in HDLC during male adolescence has been postulated to result from increased T production (16,18); however, there is a significant positive correlation between HDLC and T in adult men (13,15,25,30). In adults, pharmacologic doses of exogenous T lower HDLC (2,11).…”

Section: Discussionmentioning

confidence: 99%

“…The major aim of this analysis was to assess whether, and to what degree, T, E2, Q, and their interactions related to concentrations of HDLC, LDLC, and the ratio of LDLC to HDLC, longitudinally (over a 1-year period) in boys undergoing sexual maturation. A second aim of this study involved an attempt to resolve the apparent dichotomy of a positive relationship of endogenous T to HDLC in adult men (13,15,25,30), and an inverse association of T to HDLC in many adolescent boys (16,18).…”

Section: Discussionmentioning

confidence: 99%

“…The overall pattern of change of HDLC and LDLC during sexual maturation in boys can be associated with changes in testosterone, estradiol, and Quetelet index. Abbreviations E2, estradiol HDLC, high density lipoprotein cholesterol LDLC, low density lipoprotein cholesterol Q, Quetelet index T, testosterone TG, triglycerideThe decrement in HDLC during male adolescence has been postulated to result from increased T production (16, 18); however, there is a significant positive correlation between HDLC and T in adult men (13,15,25,30). In adults, pharmacologic doses of exogenous T lower HDLC (2, 11).…”

mentioning

confidence: 99%

“…The adult male-female differences in lipoproteins (lower HDLC, higher LDLC, and higher TG) probably account, in part, for male-premenopausal female differences in atherosclerosis (32,33,36). Understanding of the physiologic events during male adolescence (5,26) that lead to a decrement in HDLC and to an apparent inverse relationship between T and HDLC (16, 18), has considerable physiologic importance, particularly because after sexual maturation, in adult men, T is positively related to HDLC (13,15,25,30).To examine the physiology of changes in LDLC, HDLC, TG, rapid physical growth, and sexual maturation, the Princeton School Maturation Study was initiated in 1976 (29). A randomly selected sub-group of the Princeton Prevalence Program was drawn (27-297, and annual measurements of lipids, lipoproteins, blood pressure, and physical growth were made in conjunction with assessments of sexual maturation as indicated by the Tanner Scale (23,24).…”

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confidence: 99%

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Longitudinal Relationships among Endogenous Testosterone, Estradiol, and Quetelet Index with High and Low Density Lipoprotein Cholesterols in Adolescent Boys

et al. 1983

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SummaryIn a 1-year longitudinal study of 19 adolescent boys, our major aim was to assess whether, and to what degree, testosterone, estradiol, Quetelet index, and their interactions related to concentrations of high and low density lipoprotein cholesterol (HDLC, LDLC). During the I-year followup, mean HDLC and estradiol levels fell and triglycerides, LDLC, Quetelet index, and testosterone levels rose. For large decreases in estradiol, increases in testosterone were associated with decreases in HDLC. These decreases in HDLC were moderated by small decreases in Quetelet index. For boys with small decreases in estradiol, as the changes in testosterone increased, the change in HDLC varied from an increase to a decrease, except in those boys who also had a small decrease in Quetelet index, for whom the change in HDLC was positive. The greatest increases in LDLC were observed in boys having the largest increase in Quetelet index and a small decrease in estradiol; however, as the decrease in estradiol became large, the positive association of Quetelet with LDLC was moderated or nullified. For boys having large decreases in estradiol, the LDLC/HDLC ratio changed from small increments to substantial decrements as testosterone increased. As the decreases in estradiol became smaller, increases in the change of testosterone moderated the decreases in the LDLC/HDLC ratio, and large increases in Quetelet index tended to diminish this moderation. As the change in testosterone increased, the change in triglyceride increased, unless the decrease in estradiol was small. The overall pattern of change of HDLC and LDLC during sexual maturation in boys can be associated with changes in testosterone, estradiol, and Quetelet index. Abbreviations E2, estradiol HDLC, high density lipoprotein cholesterol LDLC, low density lipoprotein cholesterol Q, Quetelet index T, testosterone TG, triglycerideThe decrement in HDLC during male adolescence has been postulated to result from increased T production (16, 18); however, there is a significant positive correlation between HDLC and T in adult men (13,15,25,30). In adults, pharmacologic doses of exogenous T lower HDLC (2, 11). The reasons for this dichotomy remain to be fully explicated but different interactions of T and E2 during adolescence and adulthood may, in part, account for the opposite correlations of HDLC and T (18). For example, at the highest endogenous E2 levels, endogenous T is inversely associated with HDLC in adolescent males (18) whereas lower E2 and T levels in sexually mature men could be associated positively with HDLC.Prepubescent boys have, if anything, higher HDLC than girls (3, 28). The within-adolescence decrement in HDLC leads to the well recognized HDLC differential in sexually mature adults where men have lower HDLC, higher LDLC, and higher levels of TG than premenopausal women (14, 21). The adult male-female differences in lipoproteins (lower HDLC, higher LDLC, and higher TG) probably account, in part, for male-premenopausal female differences in atherosclerosis (32,...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Longitudinal Relationships among Endogenous Testosterone, Estradiol, and Quetelet Index with High and Low Density Lipoprotein Cholesterols in Adolescent Boys

et al. 1983

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The Relationship Between Sex Hormones and High-Density Lipoprotein Cholesterol Levels in Healthy Adult Men

Duell¹,

Bierman

1990

Arch Intern Med

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Maturity and its relationship to plasma lipid and lipoprotein levels in adolescents: The Fels longitudinal study

Baumgartner

Roche

Chumlea

et al. 1989

American J Hum Biol

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During adolescence, changes in lipid and lipoprotein levels have been reported to be associated with changes in body composition and changes in endogenous testosterone and estradiol. These hormone levels are directly correlated with sexual and skeletal maturity levels. The purpose of the present study was to determine if there are associations during pubescence and adolescence, independent of chronological age, between measures of maturity and body composition or plasma lipid and lipoprotein cholesterols. Skeletal maturity was measured on the basis of skeletal assessments of the bones of the knee joint. Age at peak height velocity was determined from serial stature measurements and, in girls, age at menarche was recorded. These measures of maturity, as well as measures of percent body fat, total body fat, total body fat mass, fat-free mass from underwater weighing, and plasma cholesterol, triglyceride, highdensity lipoprotein-cholesterol, and low-density lipoprotein-cholesterol levels from 502 observations on 174 boys and girls enrolled in the Fels Longitudinal Study were used in the analysis. Within annual chronological age groups, no associations were found between level of maturity and lipid and lipoprotein level or percent body fat in boys or girls. However, changes in lipid and lipoprotein levels over time appeared to be more apparent when age grouping were based on skeletal age than when they were based on chronological age.

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Hypertriglyceridemia and hypoalphalipoproteinemia in azoospermic and oligospermic young men: Relationships of endogenous testosterone to triglyceride and high density lipoprotein cholesterol metabolism

Cited by 53 publications

References 15 publications

Longitudinal Relationships among Endogenous Testosterone, Estradiol, and Quetelet Index with High and Low Density Lipoprotein Cholesterols in Adolescent Boys

Longitudinal Relationships among Endogenous Testosterone, Estradiol, and Quetelet Index with High and Low Density Lipoprotein Cholesterols in Adolescent Boys

The Relationship Between Sex Hormones and High-Density Lipoprotein Cholesterol Levels in Healthy Adult Men

Maturity and its relationship to plasma lipid and lipoprotein levels in adolescents: The Fels longitudinal study

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