Hypertriglyceridemia, but not Hypercholesterolemia, is Associated with the Alterations of Fibrinolytic System

Abstract

Derangements of the blood coagulation-fibrinolytic system are thought to be associated with the development of cardiovascular disease. Previous studies have identified the alterations in patients with advanced atherosclerosis, however, studies on subjects without apparent cardiovascular complications are scarce. To evaluate the potential risk of thrombosis, we examined the serum lipid levels and fibrinolytic parameters in 54 subjects of different types of primary hyperlipoproteinemia (HL) and 18 normolipidemic controls. Plasma tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) antigen levels were significantly higher in type IV HL than in the controls. Serum triglyceride concentrations were correlated with t-PA (r = 0.537, p < 0.01) and PAI-1 (r = 0.249, p < 0.05) antigen levels, while serum cholesterol levels did not. The current study demonstrated that hypertriglyceridemia, but not hypercholesterolemia, is associated with the alterations of fibrinolytic system.

Increased Interleukin‐6 levels in pituitary‐deficient patients are independently related to their carotid intima‐media thickness

“…We also observed higher serum levels of tPA‐ag in our group of GHD patients compared to nonobese controls. High levels of tPA‐ag could be expected in our GHD patients due to the observation of high IL‐6 concentrations, high triglyceride levels and more pronounced visceral adiposity compared to the controls (Leonsson et al ., 2002); three factors positively associated with high tPA‐ag concentrations (Samad et al ., 1994; Hiraga et al ., 1996; Svendsen et al ., 1996). Elevated levels of tPA‐ag has been correlated with increased risk of myocardial infarction and stroke (Ridker et al ., 1993, 1994) and the observation of high tPA‐ag in our GHD patients may contribute to the increased cardiovascular and cerebrovascular mortality observed in hypopituitary patients without GH substitution (Rosen & Bengtsson, 1990; Bulow et al ., 1997).…”

Effect of atorvastatin on different fibrinolyis mechanisms in hypercholesterolemic subjects

“…A hypofibrinolyitic state has not been clearly related to hypercholesterolemia, in which platelet activation and enhanced thrombin generation, are suggested to be the most important mechanisms involved in thrombosis development [6,24]. Thrombin generation is linked to fibrinolysis, by TAFI and factor XIII activation [25], which influence fibrinolytic activity in hypercholesterolemic subjects with respect to PAI-1 related mechanism [6].…”

Preoperative triglycerides predict post-coronary artery bypass graft survival in diabetic patients: a sex analysis.

“…Triglyceride-rich lipoproteins in the vessel wall and associated cells (23) lead to fatty streaks, which are noted in saphenous vein grafts within 18 months post-CABG (24). An enhanced blood coagulation-fibrinolytic system may be associated with both serum triglyceride concentrations (25) and the presence of diabetes (5,26). In the postmenopausal period (the typical life-cycle phase for women in this study), hepatic lipase activity rises because of an absence of estrogen, leading to an increase in small dense LDLs (27), particularly observed in the presence of a high concentration of triglyceride particles (28).…”