Hypertriglyceridemia impact on arterial parameters in patients with metabolic syndrome

Rinkūnienė, E.; Dženkevičiūtė, V.; Petrulionienė, Ž.; Majauskienė, Eglė; Ryliškytė, Ligita; Puronaitė, Roma; Badarienė, Jolita; Navickas, Rokas; Laucevičius, Aleksandras

doi:10.1186/s12872-021-02202-3

Cited by 7 publications

(3 citation statements)

References 34 publications

(33 reference statements)

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“…29 Inflammation and oxidative mechanisms may contribute, at least in part, to the rapid progression of arterial stiffness caused by smoking, heavy alcohol drinking, hypertriglyceridemia, and hyperuricemia, in addition to diabetes. 1,2,29–32 Although the pathophysiological mechanisms underlying age-related increase in the rate of progression of arterial stiffness have not yet been fully clarified, acceleration of the age-related increase in arterial stiffening was observed for each of the CVRFs, except the BMI and serum LDL-C, examined in this study, especially heavy alcohol drinking and higher serum HbA1c and triglycerides levels. Inflammation and oxidative stress are also reported to be activated with aging, 33 which could explain the acceleration of the age-related increase of arterial stiffness by CVRFs, especially heavy alcohol drinking, diabetes, and hypertriglyceridemia.…”

Section: Discussionmentioning

confidence: 62%

Lifelong Heterogeneous Contribution of Cardiovascular Risk Factors to Slow and Fast Progression of Arterial Stiffness

et al. 2023

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BACKGROUND: Although some cardiovascular risk factors (CVRFs) are known to be associated with increased arterial stiffness, increased arterial stiffness does not mediate the cardiovascular risk associated with all CVRFs. Here, based on long-term repeated-measurement data, we examined the association of the lifelong status of each CVRF with the rate of progression of arterial stiffness. METHODS: We utilized the data from annual health checkups with the brachial-ankle pulse wave velocity measurements over a 16-year period in middle-aged Japanese occupational cohort. RESULTS: Totally, 29 090 brachial-ankle pulse wave velocity data were obtained during the follow-up of 3763 subjects ranging in age from around 30 to 70 years. Smoking, heavy alcohol intake, hypertension, diabetes, hypertriglyceridemia, and hyperuricemia were independently associated with the fast progression of arterial stiffness. Also, lower values in nondisease range in blood pressure, glycosylated hemoglobin A1c, triglyceride, and uric acid were independently associated with the slow progression of arterial stiffness. For body mass index and low-density lipoprotein cholesterol, no clear associations with the progression of arterial stiffness were observed. CONCLUSIONS: The present prospective study provided more robust epidemiological evidence for the heterogeneity of the significance of contribution of lifelong status of each CVRF to the slow and fast rate of progression of arterial stiffness. These findings suggest the important need to examine, in further studies, the effects of global early interventions to control the levels of the culprit CVRFs, even from middle age, not only to prevent a fast progression of the arterial stiffness but also to maintain a relatively slow progression of arterial stiffness.

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Section: Discussionmentioning

confidence: 62%

Lifelong Heterogeneous Contribution of Cardiovascular Risk Factors to Slow and Fast Progression of Arterial Stiffness

et al. 2023

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“…Low levels of HDL with simultaneous high levels of TG are described as atherogenic dyslipidaemia, which is associated not only with the development of atherosclerosis but also insulin resistance [ 25 ]. Hypertriglyceridemia influences the mean arterial pressure, leading to arterial hypertension as well as other cardiovascular diseases [ 26 ]. Contrary to HDL, high TG levels have been widely recognised as a MetS component that is significantly correlated with 25OHD nutritional status in children and adolescents with and without obesity [ 4 , 6 , 7 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency in Obese Children Is Associated with Some Metabolic Syndrome Components, but Not with Metabolic Syndrome Itself

et al. 2023

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Vitamin D deficiency in children is a common nutritional issue in many populations worldwide, associated not only with skeletal malformations but, as recent studies suggest, also with the development of obesity and metabolic syndrome. The aim of this observational study was to assess the nutritional status of vitamin D in a group of Polish children with obesity and different grades of metabolic syndrome, with a consequent analysis of the correlation between vitamin D levels and the components of metabolic syndrome. For that purpose, the group of 78 participants (mean age: 14.18 ± 2.67 years) was recruited and further grouped in relation to vitamin D status into two groups of children with and without vitamin D deficiency. The biochemical parameters associated with obesity as well as anthropometric measures were assessed and analysed in search of significant differences between the groups. In the current group of children with obesity and vitamin D deficiency, HDL (45.00 ± 9.29) and adiponectin (7.21 ± 1.64) were found to be significantly lower than in their peers without vitamin D deficiency, whereas W/HtR (0.60 ± 0.04) and TG (171.31 ± 80.75) levels proved to be significantly higher. Body composition analysis using bioelectrical impedance returned no significant findings. The above findings suggest that vitamin D deficiency may influence lipid and glucose metabolism in children, leading to the development of abnormalities characteristic of the metabolic syndrome. A W/HtR parameter was shown to be a sensitive marker of abdominal obesity, which might provide an important means of assessing the correlation between vitamin D and this type of obesity. Independently, vitamin D deficiency may also influence the endocrinological function of adipose tissue, leading to lower concentrations of adiponectin. These in turn presented a linear correlation with the high results of the OGTT in the second hour of the test, hinting at its potential role in the pathophysiology of insulin resistance.

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“…The discrepancy can be explained by the finding that age was significantly correlated with non-fasting TG values. It has been documented that lifestyle factors including acute and habitual diet influence non-fasting TG, and higher TG values were sometimes reported in younger patients [ 8 , 9 ]. The findings in the present study probably reflect the results of younger patients preferring diets that raise TG values.…”

Section: Discussionmentioning

confidence: 99%

Non-Fasting Hypertriglyceridemia Burden as a Residual Risk of the Progression of Carotid Artery Stenosis

Miura

Yasuda

Toma

et al. 2022

IJMS

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The relationships between repeated non-fasting triglyceride (TG) measurements and carotid stenosis progression during follow-ups have never been investigated. In 111 consecutive carotid arteries of 88 patients with ≥50% atherosclerotic stenosis on at least one side, who had ≥3 blood samples taken during ≥one-year follow-ups, clinical variables were compared between carotid arteries with and without subsequent stenosis progression. To evaluate non-fasting TG burden, a new parameter area [TG ≥ 175] was calculated by integrating non-fasting TG values ≥ 175 mg/dL (i.e., TG values minus 175) with the measurement intervals (year). Carotid stenosis progression occurred in 22 arteries (19.8%) during the mean follow-up period of 1185 days. Younger age, symptomatic stenosis, higher mean values of TG during follow-ups, the area [TG ≥ 175], mean TG values ≥ 175 mg/dL and maximum TG values ≥175 mg/dL were significant factors related to the progression on univariate analyses. The cut-off value of the area [TG ≥ 175] to discriminate carotid stenosis progression was 6.35 year-mg/dL. Multivariate analyses demonstrated that symptomatic stenosis and the area [TG ≥ 175] ≥ 6.35 year-mg/dL were independently related to carotid stenosis progression. In conclusion, the area [TG ≥ 175] was an independent risk factor for carotid stenosis progression, and this study suggests the importance to continuously control non-fasting TG levels < 175 mg/dL during follow-ups to prevent carotid stenosis progression.

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Hypertriglyceridemia impact on arterial parameters in patients with metabolic syndrome

Cited by 7 publications

References 34 publications

Lifelong Heterogeneous Contribution of Cardiovascular Risk Factors to Slow and Fast Progression of Arterial Stiffness

Lifelong Heterogeneous Contribution of Cardiovascular Risk Factors to Slow and Fast Progression of Arterial Stiffness

Vitamin D Deficiency in Obese Children Is Associated with Some Metabolic Syndrome Components, but Not with Metabolic Syndrome Itself

Non-Fasting Hypertriglyceridemia Burden as a Residual Risk of the Progression of Carotid Artery Stenosis

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