Hypertriglyceridemia is positively correlated with the development of colorectal tubular adenoma in Japanese men

Tabuchi, Mari; Kitayama, Joji; Nagawa, Hirokazu

doi:10.3748/wjg.v12.i8.1261

Cited by 59 publications

(51 citation statements)

References 20 publications

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“…These associations were independent of other lipids examined in the study and were not confounded or modified by other demographic risk factors, including gallstones. Higher levels of triglycerides and lower levels of high density lipoprotein, has been reported in several other malignancies, including tumors of the colon, breast and prostate, [33][34][35] and has been implicated in gallbladder cancer etiology, due to its close relationships with gallstones, obesity, high-fat diet, and diabetes 36,37 which are also linked to gallbladder cancer 38,39 .…”

Section: Discussionmentioning

confidence: 93%

Serum estrogen level and lipid profile in Gall stone and Gallbladder cancer: a case control study

Singh¹,

Dwivedi²,

Chandra³

et al. 2013

Int Jour of Biomed Res

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Section: Discussionmentioning

confidence: 93%

Serum estrogen level and lipid profile in Gall stone and Gallbladder cancer: a case control study

Singh¹,

Dwivedi²,

Chandra³

et al. 2013

Int Jour of Biomed Res

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“…Nine studies were conducted in the USA (16,18,20,32,35,(37)(38)(39)(40) , one in Sweden (42) , five in Korea (6,9,10,22,27) , two in China (23,30) , eight in Japan (8,24,26,28,29,31,36,43) , one in Austria (41) and three in European countries (4,17,34) (Tables 1 and 2). Pooled analysis showed a significant association between serum TAG and CRN (n 29 studies; summary RR = 1·08; 95 % CI 1·05, 1·12, P < 0·00001; Fig.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Two studies were conducted in the USA (20,39) , one in Germany (19) , three in Korea (9,10,22) and three in Japan (28,29,36) ( Table 2). The results from nine studies showed that serum TC had a significant association with risk of CRA (RR = 1·04; 95 % CI 1·01, 1·09, P = 0·02) and there was no significant heterogeneity among these studies (Q = 5·26, P value for heterogeneity = 0·73, I 2 = 0 %; Table 3).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The sixteen studies on TAG (four cohort studies, four cross-sectional and eight case-control studies) and risk of CRA were published between 1990 and 2013 and involved a total of 17 830 CRA cases (Table 2) (6,(8)(9)(10)18,20,22,23,(26)(27)(28)(29)(30)(31)36,39) . Three studies were conducted in the USA (18,20,39) , five in Korea (6,9,10,22,27) , two in China (23,30) and six in Japan (8,26,28,29,31,36) (Table 2). The pooled RR for CRA was 1·06 (95 % CI 1·03, 1·10, P = 0·0009) which indicated that serum TAG was significantly associated with CRA development.…”

Section: Study Characteristicsmentioning

confidence: 99%

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The association between serum lipids and colorectal neoplasm: a systemic review and meta-analysis

Tian

Wang

et al. 2015

Public Health Nutr.

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Objective: There have been inconsistent results published regarding the relationship between dyslipidaemia and an increased risk of colorectal neoplasia (CRN), including colorectal adenoma (CRA) and colorectal cancer (CRC). We conducted a meta-analysis to explore the relationship between dyslipidaemia and CRN. Design: We identified studies by performing a literature search using PubMed, EMBASE and the Science Citation Index through October 2013. Setting: We analysed thirty-three independent studies reporting the association between CRN and at least one of the selected lipid components, including total cholesterol (TC), TAG, HDL-cholesterol (HDL-C) and LDL-cholesterol (LDL-C). Subjects: CRN cases (n 21 809) were identified. Results: Overall, people with high levels of serum TAG (risk ratio (RR) = 1·08; 95 % CI 1·05, 1·12, P < 0·00001) and LDL-C (RR = 1·07; 95 % CI 1·00, 1·14, P = 0·04) presented an increased prevalence of CRN. Subgroup analyses revealed that high levels of serum TC (RR = 1·04; 95 % CI 1·01, 1·09, P = 0·02), TAG (RR = 1·06; 95 % CI 1·03, 1·10, P = 0·0009) and LDL-C (RR = 1·11; 95 % CI 1·04, 1·19, P = 0·003) increased the risk of CRA but not of CRC. No association between serum HDL-C and risk for CRN (including CRA and CRC) was observed. Conclusions: Both TAG and LDL-C were significantly associated with an increasing prevalence of CRN. High levels of serum TC, TAG and LDL-C were positively associated with CRA but not with CRC. No significant association was observed between levels of serum HDL-C and CRN. Keywords Serum lipids Colorectal adenomaColorectal cancer TAG Meta-analysis Colorectal cancer (CRC) is reported to be the fourth most commonly diagnosed cancer and is the second most common cause of cancer deaths in North America (1) . CRC is believed to arise from colorectal adenoma (CRA) through a sequence from adenoma to adenocarcinoma as a consequence of a limited set of molecular events that largely originate with a relatively benign adenoma that progresses to cancer (2) . Accumulated data indicate that metachronous lesions occur at a rate of 20 to 30 % per year in post-polypectomy patients. The propensity to develop CRA identifies a sizeable subgroup of the population at an enhanced risk for subsequent adenoma formation and colorectal carcinoma. This indicates that identifying risk factors associated with CRN is essential for the reduction of colorectal carcinoma.The positive association between obesity and CRA prevalence demonstrates an underlying dose-response relationship according to BMI (3) . Timely screening of obese patients for CRA is thus recommended. Dyslipidaemia is an important component of metabolic syndrome and is demonstrated to contribute to colorectal tumorigenesis through insulin resistance, oxidative stress and inflammatory † The first three authors contributed equally to this work.

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“…These associations were independent of other lipids examined in the study and were not confounded or modified by other demographic or risk factors, including gallstones. Hyperlipidemia, especially higher levels of triglycerides and lower levels of HDL, has been reported in several other malignancies, including tumors of the colon, breast and prostate, [37][38][39] and has been implicated in gallbladder cancer etiology, due to its close relationships with gallstones, obesity, high-fat diet and diabetes 40,41 which are also linked to gallbladder cancer. 2,4 In contrast to the hyperlipidemic effects of total cholesterol, LDL, apo A and apo B on biliary tract cancer risk, we also observed excess risks of all 3 subsites of biliary tract cancers at low levels of total cholesterol, LDL and apo B, and high levels of apo A, independent of the other lipids and risk factors, including gallstones.…”

Section: Table III -Odds Ratios (Ors) and 95% Confidence Intervals (Cmentioning

confidence: 99%

Serum lipid levels and the risk of biliary tract cancers and biliary stones: A population‐based study in China

Andreotti

Chen

Gao

et al. 2007

Intl Journal of Cancer

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Biliary tract cancers, encompassing the gallbladder, extrahepatic bile ducts and ampulla of Vater, are rare but highly fatal malignancies. Gallstones, the predominant risk factor for biliary cancers, are linked with hyperlipidemia. As part of a populationbased case-control study conducted in Shanghai, China, we examined the associations of serum lipid levels with biliary stones and cancers. We included 460 biliary cancer cases (264 gallbladder, 141 extrahepatic bile duct, and 55 ampulla of Vater), 981 biliary stone cases and 858 healthy individuals randomly selected from the population. Participants completed an in-person interview and gave overnight fasting blood samples. Participants in the highest quintile of triglycerides (≥160 mg/dl) had a 1.4-fold risk of biliary stones (95% CI 5 1.1-1.9), a 1.9-fold risk of gallbladder cancer (95% CI 5 1.3-2.8), and a 4.8-fold risk of bile duct cancer (95% CI 5 2.8-8.1), compared to the reference group (third quintile: 90-124 mg/dl). Participants in the lowest quintile of high-density lipoprotein (HDL) (<30 mg/dl) had a 4.2-fold risk of biliary stones (95% CI 5 3.0-6.0), an 11.6-fold risk of gallbladder cancer (95% CI 5 7.3-18.5), and a 16.8-fold risk of bile duct cancer (95% CI 5 9.1-30.9), relative to the reference group (third quintile: 40-49 mg/dl). In addition, total cholesterol, low-density lipoprotein (LDL) and apolipoprotein A (apo A) were inversely associated with biliary stones; whereas low levels as well as high levels of total cholesterol, LDL, apo A and apolipoprotein B (apo B) were associated with excess risks of biliary tract cancers. Our findings support a role for serum lipids in gallstone development and biliary carcinogenesis. ' 2007 Wiley-Liss, Inc.Key words: serum lipid levels; gallstones; biliary tract cancer Biliary tract cancers, consisting of tumors of the gallbladder, extrahepatic bile ducts and ampulla of Vater, are rare but highly fatal malignancies. 1,2 Gallstones are the most important known risk factor for all three biliary tract cancer subsites. Specifically, cholesterol gallstones (composed mainly of cholesterol) and mixed gallstones (composed of both cholesterol and bilirubin) are most strongly associated with gallbladder cancer. 2,3 Furthermore, cholesterol gallstones and gallbladder cancer share a number of putative risk factors, including obesity, high fat diet and hyperlipidemia. 2,4 Hyperlipidemia is generally characterized by high serum levels of total cholesterol, triglycerides, low-density-lipoprotein (LDL), and low levels of high-density-lipoprotein (HDL). High triglycerides and low HDL have been most consistently associated with gallstones, whereas the associations of total cholesterol and LDL with gallstones are less consistent. [5][6][7] Cholesterol gallstone pathogenesis involves cholesterol saturation of the bile duct due to the hypersecretion of cholesterol from the liver 8 ; however, the exact role of individual lipids, lipoproteins and apolipoproteins is less clear.Given the relationship between hyperlipidemia and gallsto...

show abstract

Hypertriglyceridemia is positively correlated with the development of colorectal tubular adenoma in Japanese men

Cited by 59 publications

References 20 publications

Serum estrogen level and lipid profile in Gall stone and Gallbladder cancer: a case control study

Serum estrogen level and lipid profile in Gall stone and Gallbladder cancer: a case control study

The association between serum lipids and colorectal neoplasm: a systemic review and meta-analysis

Serum lipid levels and the risk of biliary tract cancers and biliary stones: A population‐based study in China

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