Hypertriglyceridemia with increased plasma insulin concentrations in cats

Hatano, Yutaka; Mori, Nobuko; Asada, Mariko; Mori, Akira; Yamamoto, Ichiro; Muranaka, S.; Kojima, Masaaki; Kigure, Megumi; Yagishita, Mizuki; Sako, Toshinori; Arai, Toshiro

doi:10.1016/j.rvsc.2009.12.012

Cited by 10 publications

(8 citation statements)

References 26 publications

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“…Serum concentrations of triglycerides were inversely moderately related to serum concentration of adiponectin in healthy cats, consistent with the hypolipidemic role of adiponectin and in agreement with findings in humans as well as the reported decreased adiponectin in cats with hypertriglyceridemia . In contrast, no association between serum concentrations of triglyceride and adiponectin was present in cats with liver disease, suggesting impairment of the mechanisms by which adiponectin normally exerts its hypolipidemic effect.…”

Section: Resultssupporting

confidence: 88%

“…5,7 Serum concentrations of triglycerides were inversely moderately related to serum concentration of adiponectin in healthy cats, consistent with the hypolipidemic role of adiponectin and in agreement with findings in humans 16 as well as the reported decreased adiponectin in cats with hypertriglyceridemia. 42 In contrast, no association between serum concentrations of triglyceride and adiponectin was present in cats with liver disease, suggesting impairment of the mechanisms by which adiponectin normally exerts its hypolipidemic effect. Similar to healthy cats, serum concentration of triglyceride was directly related to serum concentrations of insulin in cats with liver disease, suggesting preservation of the association of hyperlipidemia and insulin concentrations in a state of liver disease.…”

Section: Discussionmentioning

confidence: 96%

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Alterations in Adipokines in Feline Hepatic Lipidosis

Mazaki‐Tovi¹,

Abood

Segev

et al. 2013

Veterinary Internal Medicne

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Background: Feline hepatic lipidosis (HL) is associated with alterations in lipid and carbohydrate metabolism. The adipokines, adiponectin, and leptin have lipid-lowering and insulin-sensitizing effects.Hypothesis: Serum concentrations of adiponectin and leptin are altered in feline HL. Animals: Client-owned cats: 55 healthy and 45 with liver disease. Methods: Cats with liver disease were categorized as having HL (n = 20), HL and concurrent disease (n = 19), or other liver disease (n = 6), based on clinical signs, laboratory findings, abdominal ultrasound examination as well as liver cytopathology, histopathology, or both. Serum samples were collected and body condition score determined.Results: Mean serum concentrations of adiponectin were higher in overweight cats with HL (4.5 lg/mL), HL and concurrent disease (4.4 lg/mL), or other liver disease (6.1 lg/mL), as compared with healthy cats (1.5 lg/mL; P < .001, P < .001, and P = .04, respectively). Mean serum concentration of leptin was higher in cats with HL (9.8 ng/mL) or HL and concurrent disease (10.7 ng/mL) than healthy cats (4.9 ng/mL, P < .001 and P < .001, respectively). Cats with other liver disease had leptin concentration (4.9 ng/mL) similar to healthy cats. Concentrations of adiponectin were correlated with alanine aminotransferase activity (r = 0.40, P = .0069), and concentrations of leptin were correlated with alkaline phosphatase activity (r = 0.42, P = .0051) in cats with liver disease.Conclusions and Clinical Importance: Adipokine concentrations are altered in feline HL. Increased concentrations of adiponectin are related to liver disease, whereas increased concentrations of leptin are specifically related to HL.

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Section: Resultssupporting

confidence: 88%

Section: Discussionmentioning

confidence: 96%

Alterations in Adipokines in Feline Hepatic Lipidosis

Mazaki‐Tovi¹,

Abood

Segev

et al. 2013

Veterinary Internal Medicne

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“…Thirty‐five to forty per cent of the adult cat population are overweight or obese (Sloth, 1992; Lund et al., 2005; German, 2006; Colliard et al., 2009). Feline obesity predisposes to dyslipidemia and insulin resistance, which may ultimately lead to the development of diabetes mellitus (Scarlett and Donoghue, 1998; Lund et al., 2005; Hoenig et al., 2007; Hatano et al., 2010). In humans, the metabolic syndrome represents a cluster of risk factors related to the risk of developing type 2 diabetes and cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

“…Cats develop obesity‐induced metabolic changes that are similar to those observed in obese humans. Among others, overweight cats suffer from insulin resistance, dyslipidemia (Hoenig et al., 2007; Jordan et al., 2008; Hatano et al., 2010) and circulating adipokine changes such as increasing leptin and decreasing adiponectin concentrations. The cat could therefore prove to be an interesting spontaneous animal model of obesity‐induced metabolic alterations (Appleton et al., 2000; Hoenig et al., 2007; Ishioka et al., 2009).…”

Section: Introductionmentioning

confidence: 99%

Obesity increases initial rate of fibrin formation during blood coagulation in domestic shorthaired cats

Bjørnvad

Wiinberg

Kristensen

2011

Animal Physiology Nutrition

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Obesity predisposes to a prothrombotic state in humans, but whether a similar state occurs in obese animals is unknown. The objective of the current study was to examine the effect of body fat percentage (BF) on haemostatic parameters including thromboelastography with tissue factor as activator (TF-TEG) in client owned indoor-confined physically inactive cats. Seventy-two cats were included following an initial thorough health examination, and a complete blood count, biochemistry panel, conventional coagulation panel and a TF-TEG analysis were performed with tissue factor (1:50,000) as activator. The cats were anaesthetized, and BF was measured using Dual-energy X-ray absorptiometry. Significant difference between lean (BF < 35%, n = 26), overweight (35% < BF < 45%, n = 28) and obese (BF > 45%, n = 18) cats was identified using ANOVA. The correlation between BF, serum leptin and total adiponectin, respectively, with individual TEG and conventional coagulation parameters was evaluated. Obese cats showed a faster rate of fibrin formation (TF-TEG(R), p < 0.05), and TF-TEG(R) was positively correlated with plasma leptin levels. Increasing BF did not affect other conventional coagulation or TF-TEG parameters. In conclusion, this study indicates a connection between body fat content and altered haemostasis, also in cats. Whether feline obesity causes a hypercoagulable state of clinical relevance should be further investigated.

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“…In particular, it is reported that hyper-free fatty acidemia plays a key role in the pathology of insulin resistance and diabetes [6,12]. In cats, hypertriglyceridemia is related to a higher serum insulin concentration and lower serum adiponectin concentration, which suggests a close relationship between hyperlipemia and insulin resistance [8]. Because diabetes in cats has been considered to have a pathological condition similar to that in humans [7], it is possible that hyperlipemia also plays a role in the pathology of diabetes in cats.…”

mentioning

confidence: 99%

Experimental Hyperlipemia Induces Insulin Resistance in Cats

Nishii

Murahata

et al. 2012

J. Vet. Med. Sci.

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ABSTRACT. The effect of experimental hyperlipemia on insulin sensitivity was evaluated in seven healthy cats. Serum triglyceride and free fatty acid concentrations were significantly (P<0.05) higher when lipid-heparin was administered (2,894  1,526 mg/dl and 4.54  0.70 mEq/l, respectively) than when saline was administered (70  42 mg/dl and 0.22  0.08 mEq/l, respectively). A glucose clamp test revealed that the mean glucose infusion rate when lipid-heparin was administered (5.80 ± 0.67 mg/kg/min) was significantly (P<0.05) lower than when saline was administered (8.52  1.83 mg/kg/min). These results suggest that experimental hyperlipemia induced insulin resistance in the healthy cats. Hyperlipemia has been related to the pathogenesis of obesity and diabetes in humans. In particular, it is reported that hyper-free fatty acidemia plays a key role in the pathology of insulin resistance and diabetes [6,12]. In cats, hypertriglyceridemia is related to a higher serum insulin concentration and lower serum adiponectin concentration, which suggests a close relationship between hyperlipemia and insulin resistance [8]. Because diabetes in cats has been considered to have a pathological condition similar to that in humans [7], it is possible that hyperlipemia also plays a role in the pathology of diabetes in cats.To evaluate the relationship between hyperlipemia and insulin resistance, an experimental hyperlipemic model has been used in humans and dogs [3,9]. Generally, a lipid preparation combined with heparin sodium is administered to induce experimental hyperlipemia in studies. However, there are only few studies reporting the effects of intravenous lipid infusion on feline glucose metabolism. In this study, experimental hyperlipemia was induced by lipid infusion in cats, and then the effect of experimental hyperlipemia on insulin sensitivity was evaluated.Experimental protocols were approved by the Animal Research Committee of Tottori University. Seven cats (3 castrated males and 4 spayed females, mean age of 7.7 ± 1.7, mean body weight of 3.9 ± 0.7 kg) were used in the study. The cats were assessed as healthy on the basis of the results of a physical examination, CBC count and serum biochemical analysis. Each of the cats was examined under two conditions, administration of lipid-heparin and administration of saline with a 2-to 3-week washout period between conditions. After fasting for 15 hr, hyperlipemia was induced according to the method of a previous canine study [3] with slight modification. Briefly, the cats received continuous infusion of 20% fat emulsion (Intralipid, Fresenius Kabi Japan, Tokyo, Japan) containing 16 mU/ml of heparin sodium (Fuji Pharma, Tokyo, Japan) or saline into the cephalic vein at a rate of 3 ml/kg body weight/hr. Three hours later, serum samples for measurement of the triglyceride (DRI-CHEM, Fuji Medical, Tokyo, Japan) and free fatty acid concentrations (NEFA-HR2, Wako, Tokyo, Japan) were collected, and then general anesthesia was induced with propofol (15 mg/cat, IV) and maintained ...

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Hypertriglyceridemia with increased plasma insulin concentrations in cats

Cited by 10 publications

References 26 publications

Alterations in Adipokines in Feline Hepatic Lipidosis

Alterations in Adipokines in Feline Hepatic Lipidosis

Obesity increases initial rate of fibrin formation during blood coagulation in domestic shorthaired cats

Experimental Hyperlipemia Induces Insulin Resistance in Cats

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