Hypertriglyceridemic Waist and Metabolic Abnormalities in Brazilian Schoolchildren

Guilherme, Flávio Ricardo; Fernandes, Carlos Alexandre Molena; Hintze, Luzia Jaeger; Fávero, Maria Teresa Martins; Cuman, Roberto Kenji Nakamura; Rinaldi, Wilson

doi:10.1371/journal.pone.0111724

Cited by 9 publications

(9 citation statements)

References 20 publications

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“…Nationwide, Guilherme et al 21 obtained results similar to those found in this study in research with students aged 10 to 14 years from public and private schools in Paraná, of whom 20.7% presented simultaneously increased WC and serum TG. On the other hand, lower percentages have also been documented in the scientific literature.…”

Section: Discussionsupporting

confidence: 87%

“…16 Besides, as hypertriglyceridemia results from excessive carbohydrate consumption, and VLDL is a triglyceride-rich lipoprotein responsible for its transport to peripheral tissues, the association between abnormal VLDL and HTGW may be justified by the predominant glycemic inadequacy in the sample, since this lipoprotein is carbohydrate-dependent. Similarly, Conceição-Machado et al 21 also evidenced a correlation between this phenotype and the atherogenic lipid profile in a healthy population of the same age group, recommending the use of this tool as a practical way of screening children and adolescents with cardiometabolic abnormalities.…”

Section: Discussionmentioning

confidence: 80%

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Hypertriglyceridemic Waist and Associated Factors in Children and Adolescents With Type 1 Diabetes Mellitus

Silva

Oliveira

et al. 2020

Rev. paul. pediatr.

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Objective: To assess the frequency of the hypertriglyceridemic waist phenotype and its associated factors in children and adolescents with type 1 diabetes mellitus. Methods: This is an observational analytical study with individuals with type 1 diabetes mellitus, aged 5 to 18 years, of both genders, followed in a university hospital in the Brazilian Northeast. Weight, height, and waist circumference were measured, and the lipid profile and glycated hemoglobin were analyzed. The hypertriglyceridemic waist phenotype was defined by the simultaneous presence of increased waist circumference (≥90th percentile for age and gender) and elevated serum triglyceride levels (≥75 mg/dL for children and ≥90 mg/dL for adolescents). We also investigated the family history of cardiovascular diseases and diabetes, as well as sociodemographic and behavioral variables. In the statistical inference tests, the proportions were compared by Pearson’s chi-square test and/or Fisher’s exact test, being significant p<0.05. Results: A total of 102 patients were evaluated, most of them females (54.9%) and adolescents (66.7%). The frequency of hypertriglyceridemic waist was 23.5%, which was associated with females (p=0.043), overweight (p=0.023), hypercholesterolemia (p=0.002), high LDL (p=0.001), and borderline VLDL (<0.001). Conclusions: The frequency of the hypertriglyceridemic waist phenotype was associated with females, atherogenic lipid profile, and overweight, indicating the importance of the nutritional monitoring of this population, aiming at reducing future cardiovascular diseases.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 80%

Hypertriglyceridemic Waist and Associated Factors in Children and Adolescents With Type 1 Diabetes Mellitus

Silva

Oliveira

et al. 2020

Rev. paul. pediatr.

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“…As already mentioned, the HTW picture includes the combination of abdominal obesity and elevated TG (dyslipidemia) and, in the present study, 27.9% of students presented this diagnosis. In 2014, in the same population and city, with the same classification criteria, the prevalence of HTW was 20.7% 6 , that is, in five years the incidence was 7.2%. Different prevalences have been reported in the literature, similar values have also been observed considering HTW assessments in different places around the world 26,27 , and in Brazil 2-28 , however, in all of them, the criteria and cutoff points were different.…”

Section: Discussionmentioning

confidence: 93%

“…The sample calculation resulted from the total number of the population (n=3.483); a prevalence of 20.7% of HTW in schoolchildren in the same city in 2014 6 confidence level equal to 95%; and sampling error of 4%. Based on these parameters, data from 354 students were required.…”

Section: Methodsmentioning

confidence: 99%

Hypertrigliceridemic Waist, Physical Activity and Cardiovascular Risk Factors in Schoolchildren

Guilherme

Santos

Fiorillo

et al. 2020

Preprint

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32The present study aimed to analyze the prevalence of the Hypertriglyceridemic 33 Waist (HTW) and its rates with levels of physical activity, nutritional status and 34 lipid profile of students from public schools. A sample consisted of 448 35 schoolchildren between 10 and 18 years old, who are assessed by body mass, 36 height, BMI (waist circumference), triglycerides, total cholesterol, HDL-C, LDL-C, 37 non-HDL cholesterol, fasting blood glucose and weekly physical activity time. The 38 survey results showed a high prevalence of the HTW phenotype in schoolchildren 39 (n = 125; 27.9%). The group diagnosed with phenotype has higher body mass, 40 BMI, total cholesterol, LDL-C and non-HDL cholesterol and a lower level of HDL-41 C about the group without a diagnosis of the phenotype. However, for fasting 42 blood glucose measurements and time of physical activity, the groups are no 43 different. An association analysis using logistic regression showed the HTW 44 phenotype associated with sex, nutritional status, and total cholesterol, where 45 boys presented 2.0 (95% CI 1.3 -3.2); obese 6.2 (95% CI 2.7 -17.2) and 46 cholesterol levels above 150 mg / dL 3.5 (95% CI 2.1 -5.7) times more likely to 47 have the phenotype. In this way, the present research showed a high prevalence 48 of HTW in schoolchildren from public schools, with boys, obese and 49 schoolchildren with total cholesterol levels, the individuals most likely to have the 50 phenotype. However, it is worth emphasizing the importance of monitoring these 51 variables throughout the year in all courses, given the period of strong, biological, 52 behavioral and psychological changes, as they can quickly change the values of 53 the analyzed variables. 54 55 Key-Words: motor activity, dyslipidemias, blood glucose. 56 57 58 2000s when Lemieux et al., (2000) 1 investigated the hypothesis that variables 62 considered simple such as waist circumference (WC) and plasma triglyceride 63 levels (TG) fasting could be used as useful tools in the identification of risk factors 64 for the development of cardiovascular diseases. 65 Currently, the HTW phenotype is defined as the joint presence of elevated 66 levels of CC and TG, 2 , and those diagnosed in turn, have a higher chance of 67 having increased blood glucose and systemic arterial hypertension, being more 68 prone to the development of the metabolic syndrome and pathologies classified 69 as risk factors for cardiovascular diseases 2 . 70To prevent the HTW phenotype and the risk factors associated with the 71 phenotype in children and adolescents, regular physical activity is 72 recommended 3 , because, in addition to the preventive characters in these age 73 groups, good levels of physical activity provide greater health benefits, presenting 74 better cardiorespiratory and muscular fitness, bone health and maintenance of 75 adequate body weight 4 . 76Despite the association of HTW with body adiposity 3 and consequently 77 the increased cardiometabolic risk in children and adolescents 5 , few studies have 7...

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“… 22 Investigations involving Brazilian adolescents found the occurrence of HTW phenotype from 2.6% to 20,7%. 5 , 6 These differences among prevalence of HTW phenotype can reflect the lack of world standardization for measuring the waist circumference, and the serum concentrations of triglycerides for the age, moreover the variations of the cutoff used to classify the HTW phenotype, which is an obstacle to the comparison of the investigations. Besides, the differences of lifestyle, genetic background and ethnicity interfere with the accumulation of abdominal fat and can explain the divergent results of the HTW phenotype prevalence.…”

Section: Discussionmentioning

confidence: 99%

Hypertriglyceridemic Waist Phenotype and Changes in the Fasting Glycemia and Blood Pressure in Children and Adolescents Over One-Year Follow-Up Period

Costa¹,

Assis²,

Cunha³

et al. 2017

Arquivos Brasileiros De Cardiologia

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BackgroundThe hypertriglyceridemic waist (HTW) phenotype is defined as the simultaneous presence of increased waist circumference (WC) and serum triglycerides (TG) levels and it has been associated with cardiometabolic risk in children and adolescents.ObjectiveThe objective was to evaluate the influence of HTW phenotype in the fasting glycemia and blood pressure in children and adolescents over one-year follow-up period.MethodsIt is a cohort study involving 492 children and adolescents from 7 to 15 years old, both genders, who were submitted to anthropometric, biochemical and clinical evaluation at the baseline, and also after 6 and 12 months of follow-up. Generalized Estimating Equation (GEE) models were calculated to evaluate the longitudinal influence of the HTW phenotype in the glycemia and blood pressure over one-year.ResultsIt was observed a prevalence of 10.6% (n = 52) of HTW phenotype in the students. The GEE models identified that students with HTW phenotype had an increase of 3.87 mg/dl in the fasting glycemia mean (CI: 1.68-6.05) and of 3.67mmHg in the systolic blood pressure (SBP) mean (CI: 1.55-6.08) over one-year follow-up, after adjusting for confounding variables.ConclusionsThe results of this study suggest that HTW phenotype is a risk factor for longitudinal changes in glycemia and SBP in children and adolescents over one-year follow-up period.

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Hypertriglyceridemic Waist and Metabolic Abnormalities in Brazilian Schoolchildren

Cited by 9 publications

References 20 publications

Hypertriglyceridemic Waist and Associated Factors in Children and Adolescents With Type 1 Diabetes Mellitus

Hypertriglyceridemic Waist and Associated Factors in Children and Adolescents With Type 1 Diabetes Mellitus

Hypertrigliceridemic Waist, Physical Activity and Cardiovascular Risk Factors in Schoolchildren

Hypertriglyceridemic Waist Phenotype and Changes in the Fasting Glycemia and Blood Pressure in Children and Adolescents Over One-Year Follow-Up Period

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