Hypertrophic cardiomyopathy: Cardiac structural and microvascular abnormalities as evaluated with multi-parametric MRI

Zhang, Yudong; Li, Meijiao; Qi, Liang; Wu, Chen‐Jiang; Wang, Xiaoying

doi:10.1016/j.ejrad.2015.04.028

Cited by 8 publications

(3 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is different from the microcirculation disorder caused by coronary atherosclerotic heart disease. To further explore the in uence of myocardial thickness on myocardial microcirculation perfusion in nonobstructive HCM patients, our study con rmed that compared with nonhypertrophic segmental myocardium, myocardial microcirculation perfusion injury in hypertrophic myocardial segments was more severe, which indirectly con rmed pathologically that in hypertrophic myocardial segments in nonobstructive HCM patients, the arrangement of segmental cardiomyocytes is more disordered and brous tissue proliferation is more obvious [12] . On the other hand, as the thickness of the myocardium increases in patients with nonobstructive HCM, myocardial microcirculation perfusion injury becomes more serious.…”

Section: Discussionmentioning

confidence: 65%

Relationship between myocardial microcirculation perfusion and myocardial mechanics in nonobstructive hypertrophic cardiomyopathy at rest

Nan

Guan

Chào

et al. 2022

Preprint

View full text Add to dashboard Cite

Objective To quantitatively analyze myocardial microcirculation perfusion in nonobstructive hypertrophic cardiomyopathy (HCM) patients, evaluate myocardial mechanics characteristics in nonobstructive HCM and explore the relationship between microcirculation perfusion and myocardial mechanics in nonobstructive HCM patients. Methods Twenty-eight healthy volunteers and twenty-eight nonobstructive HCM patients were recruited as the case group. All subjects underwent two-dimensional echocardiography, contrast-enhanced myocardial ultrasound (MCE), and two-dimensional speckle tracking imaging (2D-STI).The nonobstructive HCM patients were divided into a hypertrophic segmental myocardium (HS) group and a nonhypertrophic segmental myocardium (NHS) group according to the degree of myocardial hypertrophy. Results (1) There were no statistically significant differences in age, height, weight, body surface area, systolic blood pressure, diastolic blood pressure, or heart rate between the nonobstructive HCM and control groups (P > 0.05). Myocardial thickness (MT), tricuspid regurgitation (TR), E/e', the left atrial volume (LAV) and the left atrial volume index (LAVI) increased in the nonobstructive HCM group, while stroke volume (SV), end-diastolic volume (EDV), end-systolic volume (ESV) and E/A decreased, and the differences were statistically significant (P < 0.05). (2) Compared with those in the control group, peak intensity (PI) and area under the curve (AUC) in the nonobstructive HCM group decreased, s-RS, s-PI, s-TTP and s-AUC in the HS group decreased, and s-PI and s-AUC in the NHS group decreased. The differences were statistically significant (P < 0.05). (3) The nonobstructive HCM group showed a significant decrease in GLS compared with the control group (P < 0.05), although the change in GCS was not significant (P > 0.05), and GLS and GCS were not significantly different between the HS and NHS groups (P > 0.05). (4) In the HS group, PI, AUC, s-PI, s-AUC and GLS were positively correlated, s-TTP was negatively correlated with GLS and GCS (P < 0.05), and RS and s-RS had no correlation with GLS and GCS. Conclusion In nonobstructive HCM patients, myocardial microcirculation perfusion and longitudinal strain of the myocardium were impaired in both hypertrophic and nonhypertrophic segmental myocardium. Hypertrophic myocardial segments in nonobstructive HCM patients have more significant damage and close correlations with changes in myocardial mechanics.

show abstract

Section: Discussionmentioning

confidence: 65%

Relationship between myocardial microcirculation perfusion and myocardial mechanics in nonobstructive hypertrophic cardiomyopathy at rest

Nan

Guan

Chào

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…• β-АБ, верапамил**, дилтиазем рекомендованы пациентам с необструктивной ГКМП и стенокардитическими болями при отсутствии обструктивной коронарной болезни сердца [3,4,74,77,251,292,329,351,352 Лечение ФП у пациентов с ГКМП ФП является наиболее частой аритмией при ГКМП, распространенность которой зависит от тяжести заболевания: 22% в общей когорте и до 32% в когорте пациентов с показаниями для имплантации ИКД*** и ЭКС***/ДЭКС*** [11,31,129,134,150,184,197,314,[354][355][356][357]. Частота встречаемости ФП de novo в общей когорте ГКМП составляет ~2% в год [129,314,356].…”

Section: лечение синдрома стенокардии у пациентов с гкмпunclassified

2020 Clinical practice guidelines for Hypertrophic cardiomyopathy

Габрусенко¹,

Гудкова²,

Козиолова³

et al. 2021

Russ J Cardiol

View full text Add to dashboard Cite

Russian Society of Cardiology (RSC)With the participation: Russian Association of Cardiovascular SurgeonsEndorsed by: Research and Practical Council of the Ministry of Health of the Russian Federation Task Force: Gabrusenko S.A. (Chairman), Gudkova A.Ya.* (Chairman), Koziolova N.A. (Chairman), Alexandrova S.A., Berseneva M.I., Gordeev M.L., Dzemeshkevich S.L., Zaklyazminskaya E.V., Irtyuga O.B., Kaplunova V.Yu., Kostareva A.A., Krutikov A.N., Malenkov D.A., Novikova T.N., Saidova M.A., Sanakoev M.K., Stukalova O.V.

show abstract

“…NETs represent part of a continuum of sterile inflammation and thrombosis [20][21][22][23][24][25][26][27][28][29][30][31] (Table 1). In the context of HCM, NET-mediated microvascular dysfunction and thrombosis may contribute to tissue injury, at least in part associated with recurring cycles of ischemia and reperfusion, inflammation, fibrosis and ventricular remodeling 32,33 .…”

Section: Nets and Microvascular Thrombosismentioning

confidence: 99%

Tissue-level inflammation and ventricular remodeling in hypertrophic cardiomyopathy

Becker

Owens

Sadayappan

2020

J Thromb Thrombolysis

View full text Add to dashboard Cite

Hypertrophic cardiomyopathy: Cardiac structural and microvascular abnormalities as evaluated with multi-parametric MRI

Cited by 8 publications

References 45 publications

Relationship between myocardial microcirculation perfusion and myocardial mechanics in nonobstructive hypertrophic cardiomyopathy at rest

Relationship between myocardial microcirculation perfusion and myocardial mechanics in nonobstructive hypertrophic cardiomyopathy at rest

2020 Clinical practice guidelines for Hypertrophic cardiomyopathy

Tissue-level inflammation and ventricular remodeling in hypertrophic cardiomyopathy

Contact Info

Product

Resources

About