Hypertrophic cardiomyopathy: lessons from history

Abstract

The modern description of hypertrophic cardiomyopathy is credited to the London pathologist, Robert Donald Teare who likened the disease to "a tumour of the heart" and published his observations in the British Heart Journal 50 years ago. Teare recognised asymmetrical hypertrophy and myocyte disarray as a familial condition associated with premature and sudden death in young people. He rightly deserves the accolade for bringing a poorly understood, but well recognised phenomenon into the public domain. Thick and heavy hearts had been of interest and investigation to physicians and pathologists for many centuries. This article reviews the early history of hypertrophic cardiomyopathy and reflects on several centuries of progress in our understanding of the condition.

MR Imaging in Hypertrophic Cardiomyopathy: From Magnet to Bedside

“…Though several reports suggest that HCM had already been recognized centuries ago, it was not until the late 1950s that the disease was brought to the attention of the international medical community (6). Brock, Morrow et al, and Braunwald et al reported functional obstruction of the left ventricle (LV) occurring at the LV outflow tract, simulating aortic stenosis, an entity defined as "idiopathic hypertrophic subaortic stenosis" (7)(8)(9).…”

Die hypertrophe Kardiomyopathie

“…Jahrhundert zurückverfol-gen, so hat die moderne wissenschaftliche Befassung mit der Erkrankung erst in den 60er-Jahren des 20. Jahrhunderts begonnen [6]. Über 50 Jahre später sind bereits viele der beteiligten genetischen und postgenetischen Mechanismen und Umbauvorgänge dieser Form der pathologischen Hypertrophie erkannt und in Ansätzen verstanden [9].…”

Historical and modern aspects of diagnostics and treatment of hypertrophic cardiomyopathy: literature review

“…После операции, не-смотря на небольшой объем иссеченного миокарда, отметили клиническое улучшение, уменьшение выра-женности систолического шума. Пациента выписали без осложнений [49].…”

“…В 1960 г. впечатленный результатами пилоро-томии при пилоростенозе британских хирургов Morrow A.G. решил, что данный принцип может быть эффективен и при динамическом стенозе вы-ходного тракта левого желудочка [49]. Достаточно смелое решение, учитывая возраст открытой кар-диохирургии, а также доступные в тот период диа-гностические возможности.…”